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Melanins

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Encyclopedia of Astrobiology

Definition

“Melanins” is a generic term commonly used to define dark and insoluble pigments found in living organisms, including animals, plants, and microorganisms (fungi and bacteria), arising biosynthetically from the oxidative polymerization of L-tyrosine or other phenolic substrates. A recent classification of melanins includes the black-to-dark brown eumelanins and the reddish-brown sulfur-containing pheomelanins (in animals), neuromelanin (in catecholaminergic regions of the brain), allomelanins (in plants and fungi), and pyomelanin (in bacteria). Melanins display a peculiar set of physicochemical properties that have been implicated as underlying most of their biological roles including photoprotection, camouflage, and virulence, denoting per se a melanin-like pigment.

Overview

The origin of the term “Melanins” (from μελας, black) is attributed to the Swedish chemist Berzelius (1840) with reference to the dark pigment found in eye membranes and was initially used to denote the...

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References

  • Bell AA, Wheeler MH (1986) Biosynthesis and functions of fungal melanins. Annu Rev Phytopathol 24:411

    Article  Google Scholar 

  • Berzelius JJ (1840) Lehrbuch der Chemie Dritte ungearbeitete und vermehrte Original Auflage, Dresden & Liepzig, in der Arnoldischen Buchhandlung 9:22–24

    Google Scholar 

  • Brenner M, Hearing VJ (2008) The protective role of melanin against UV damage in human skin. Photochem Photobiol 84:539

    Article  Google Scholar 

  • d’Ischia M, Wakamatsu K, Napolitano A, Briganti S, Garcia-Borron J-C, Kovacs D, Meredith P, Pezzella A, Picardo M, Sarna T, Simon JD, Ito S (2013) Melanins and melanogenesis: methods, standards, protocols. Pigment Cell Melanoma Res 26:616

    Article  Google Scholar 

  • d’Ischia M, Napolitano A, Pezzella A, Meredith P, Buehler M (2020) Melanin biopolymers: tailoring chemical complexity for materials design. Angew Chem Int Ed 59:11196

    Article  Google Scholar 

  • Dubey S, Roulin A (2014) Evolutionary and biomedical consequences of internal melanins. Pigment Cell Melanoma Res 27:327

    Article  Google Scholar 

  • Feldmesser M, Kress Y, Novikoff P, Casadevall A (2000) Cryptococcus neoformans is a facultative intracellular pathogen in murine pulmonary infection. Infect Immun 68:4225

    Google Scholar 

  • Glagoleva AY, Shoeva OY, Khlestkina EK (2020) Melanin pigment in plants: current knowledge and future perspectives. Front Plant Sci 11:770

    Article  Google Scholar 

  • Glass K, Ito S, Wilby PR, Sota T, Nakamura A, Bowers CR, Vinther J, Dutta S, Summons R, Briggs DEG, Wakamatsu K, Simon JD (2012) Direct chemical evidence for eumelanin pigment from the Jurassic period. Proc Natl Acad Sci U S A 109:10218

    Article  ADS  Google Scholar 

  • Hu D, Clarke JA, Eliason CM, Qiu R, Li Q, Shawkey MD, Zhao C, D’Alba L, Jiang J, Xu X (2018) A bony-crested Jurassic dinosaur with evidence of iridescent plumage highlights complexity in early paravian evolution. Nat Commun 9:217

    Article  ADS  Google Scholar 

  • Ju KY, Lee Y, Lee S, Park SB, Lee J-K (2011) Bioinspired polymerization of dopamine to generate melanin-like nanoparticles having an excellent free-radical-scavenging property. Biomacromolecules 12:625

    Article  Google Scholar 

  • Lindgren J, Moyer A, Schweitzer MH, Sjövall P, Uvdal P, Nilsson DE, Heimdal J, Engdahl A, Gren JA, Schultz BP, Kear BP (2015) Interpreting melanin-based coloration through deep time: a critical review. Proc R Soc B 282:20150614

    Article  Google Scholar 

  • Liu Y, Ai K, Liu J, Deng M, He Y, Lu L (2013) Dopamine-melanin colloidal nanospheres: an efficient near-infrared photothermal therapeutic agent for in vivo cancer therapy. Adv Mater 25:1353

    Article  Google Scholar 

  • Lyakh SP (1981) Microbial melanogenesis and its functions. Nauka 22:270

    Google Scholar 

  • Malo ME, Dadachova E (2019) Fungi in extreme environments: ecological role and biotechnological significance. Springer, Cham, pp 175–184

    Book  Google Scholar 

  • Manning PL, Edwards NP, Bergmann U, Anné J, Sellers WI, van Veelen A, Sokaras D, Egerton VM, Alonso-Mori R, Ignatyev K, van Dongen BE, Wakamatsu K, Ito S, Knoll F, Wogelius RA (2019) Pheomelanin pigment remnants mapped in fossils of an extinct mammal. Nat Commun 10:2250

    Article  ADS  Google Scholar 

  • McNamara ME, Kaye JS, Benton MJ, Orr PJ, Rossi V, Ito S, Wakamatsu K (2018) Non-integumentary melanosomes can bias reconstructions of the colours of fossil vertebrates. Nat Commun 9:2878

    Article  ADS  Google Scholar 

  • Menter JM, Willis I (1997) Electron transfer and photoprotective properties of melanins in solution. Pigment Cell Melanoma Res 10:214

    Article  Google Scholar 

  • Negro JJ, Finlayson C, Galván I (2018) Melanins in fossil animals: is it possible to infer life history traits from the coloration of extinct species? Int J Mol Sci 19:230

    Article  Google Scholar 

  • Nicolaus RA (1968) Melanins. Herman, Paris

    Google Scholar 

  • Pinheiro FL, Prado G, Ito S, Simon JD, Wakamatsu K, Anelli LE, Andrade JAF, Glass K (2019) Chemical characterization of pterosaur melanin challenges color inferences in extinct animals. Sci Rep 9:15947

    Article  ADS  Google Scholar 

  • Prota G (1992) Melanins and melanogenesis. Academic Press Inc, San Diego

    Google Scholar 

  • Riley PA (1997) Melanin. Int J Biochem Cell Biol 29:1235–1239

    Article  Google Scholar 

  • Rossi V, McNamara ME, Webb SM, Ito S, Wakamatsu K (2019) Tissue-specific geometry and chemistry of modern and fossilized melanosomes reveal internal anatomy of extinct vertebrates. Proc Natl Acad Sci U S A 116:17880

    Article  ADS  Google Scholar 

  • Schmaler-Ripcke J, Sugareva V, Gebhardt P, Winkler R, Kniemeyer O, Heinekamp T, Brakhage AA (2009) Production of pyomelanin, a second type of melanin, via the tyrosine degradation pathway in Aspergillus fumigatus. Appl Environ Microbiol 75:493

    Google Scholar 

  • Tran-Ly AN, Reyes C, Schwarze FWMR, Ribera J (2020) Microbial production of melanin and its various applications. World J Microbiol Biotechnol 36:170

    Article  Google Scholar 

  • Trias J, Viñas M, Guinea J, Lorèn JG (1989) Brown pigmentation in Serratia marcescens cultures associated with tyrosine metabolism. Can J Microbiol 35:1037

    Article  Google Scholar 

  • Vinther J (2015) A guide to the field of palaeo colour: melanin and other pigments can fossilise: reconstructing colour patterns from ancient organisms can give new insights to ecology and behaviour. BioEssays 37:643

    Article  Google Scholar 

  • Vinther J, Nicholls R, Lautenschlager S, Pittman M, Kaye TG, Rayfield E, Mayr G, Cuthill IC (2016) 3D camouflage in an ornithischian dinosaur. Curr Biol 26:2456

    Article  Google Scholar 

  • Wang Y, Casadevall A (1994) Decreased susceptibility of melanized Cryptococcus neoformans to UV light. Appl Environ Microbiol 60:3864

    Article  ADS  Google Scholar 

  • Zhang F, Kearns SL, Orr PJ, Benton MJ, Zhou Z, Johnson D, Xu X, Wang X (2010) Fossilized melanosomes and the colour of cretaceous dinosaurs and birds. Nature 463:1075

    Article  ADS  Google Scholar 

  • Zhdanova NN, Borisyuk LG, Vasilevskaya AI, Lashko TN, Redchitz TI, Gavrilyuk VI (1991) Interactions of the soil micromycetes with ‘hot’ particles in model system. Microbiologichny Zhurnal 53:9

    Google Scholar 

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Correspondence to Marco d’Ischia .

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d’Ischia, M., Manini, P. (2023). Melanins. In: Gargaud, M., et al. Encyclopedia of Astrobiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-65093-6_5456

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