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Zerebrale Sinus- und Venenthrombosen

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Klinische Neurologie

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Zusammenfassung

Thrombosen der zerebralen Sinus und Venen sind eine klinische Entität, deren tatsächliche Inzidenz aufgrund ihrer extrem heterogenen Symptomatik unbekannt ist. Zudem sind Kopfschmerzen nicht selten alleiniges Symptom, sodass wahrscheinlich viele (oligosymptomatische) Fälle unerkannt bleiben. Auch bei Patientinnen mit den typischen Symptomen eines Pseudotumor cerebri muss an eine zerebrale Sinusthrombose gedacht werden. Sowohl die CT-gestützte Venografie als auch die MR-Venografie sowie blutsensitive MR-Sequenzen sind zum Nachweis bzw. Ausschluss intrakranieller Venenthrombosen geeignet, wohingegen, anders als bei Thrombosen von Bein- oder Beckenvenen, Laborwerte (D-Dimere) keine ausreichende diagnostische Sicherheit bieten. Trotz geringer Evidenz gilt die Antikoagulation sowohl in der Akutphase als auch in der Sekundärprävention als Therapie der Wahl.

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Literatur

  • Alons IME, Jellema K, Wermer MJH et al (2015) D-dimer for the exclusion of cerebral venous thrombosis: a meta- analysis of low risk patients with isolated headache. BMC Neurol 15:118

    PubMed  PubMed Central  Google Scholar 

  • Alper F, Kantarci M, Dane S et al (2004) Importance of anatomical asymmetries of transverse sinuses: an MR venographic study. Cerebrovasc Dis 18:236–239

    PubMed  Google Scholar 

  • Baumgartner RW (2003) Transcranial color duplex sonography in cerebrovascular disease – a systematic review. Cerebrovasc Dis 16:4–13

    PubMed  Google Scholar 

  • Biousse V, Ameri A, Bousser MG (1999) Isolated intracranial hypertension as the only sign of cerebral venous thrombosis. Neurology 53:1537–1542

    CAS  PubMed  Google Scholar 

  • Bousser MG, Barnett HJM (2004) Cerebral venous thrombosis. In: Mohr JP, Choi DW, Grotta JC, Weir B, Wolf PA (Hrsg) Stroke – pathophysiology, diagnosis, and management, 4. Aufl. Churchill Livingstone, Philadelphia, S 301–325

    Google Scholar 

  • Bousser MG, Chiras J, Bories J et al (1985) Cerebral venous thrombosis. A review of 38 cases. Stroke 16:199–213

    CAS  PubMed  Google Scholar 

  • de Bruijn SFTM, de Stam J, Kappelle J, for the Cerebral Venous Sinus Thrombosis Study Group (1996) Thunderclap headache as first symptom of cerebral venous sinus thrombosis. Lancet 348:1623–1625

    PubMed  Google Scholar 

  • de Bruijn SFTM, de Stam J, for the Cerebral Venous Sinus Thrombosis Study Group (1999) Randomized, placebo-controlled trial of anticoagulant treatment with low-molecular-weight heparin for cerebral sinus thrombosis. Stroke 30:484–488

    PubMed  Google Scholar 

  • Chik Y, Gottesmann RF, Zeiler SR et al (2012) Differentiation of transverse sinus thrombosis from congenitally atretic cerebral transverse sinus with CT. Stroke 43:1968–1970

    PubMed  PubMed Central  Google Scholar 

  • Coutinho JM, de Bruijn SFTM, de Weber G et al (2012) Anticoagulation for cerebral venous sinus thrombosis. Stroke 43:e41–e42

    PubMed  Google Scholar 

  • Coutinho JM, Zuurbier SM, Stam J (2014) Declining mortality in cerebral venous thrombosis. A systematic review. Stroke 45:1338–1341

    PubMed  Google Scholar 

  • Crassard I, Soria C, Tzourio C et al (2005) A negative D-dimer assay does not rule out cerebral venous thrombosis. A series of seventy-three patients. Stroke 36:1716–1719

    PubMed  Google Scholar 

  • Cumurciuc R, Crassard I, Sarov M et al (2005) Headache as the only neurological sign of cerebral venous thrombosis: a series of 17 cases. JNNP 76:1084–1087

    CAS  Google Scholar 

  • Damak M, Crassard I, Wolff V et al (2009) Isolated lateral sinus thrombosis. A series of 62 patients. Stroke 40:476–481

    PubMed  Google Scholar 

  • Erbguth F (2002) Sinusvenenthrombose. In: Hamann GF, Siebler M, von Scheidt W (Hrsg) Schlaganfall. Klinik, Diagnostik, Therapie. Interdisziplinäres Handbuch. ecomed, Landsberg, S 222–230

    Google Scholar 

  • Farb RI, Scott JN, Willinsky RA et al (2003) Intracranial venous system: gadolinium-enhanced three-dimensional MR venography with auto-triggered elliptic centric-ordered sequence. Initial experience. Radiology 226:203–209

    PubMed  Google Scholar 

  • Ferro JM, Canhão P, Stam J, for the ISCVT Investigators et al (2004) Prognosis of cerebral vein and dural sinus thrombosis: results of the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT). Stroke 35:664–670

    PubMed  Google Scholar 

  • Ferro JM, Canhão P, Bousser MG, for the ISCVT Investigators et al (2005) Cerebral vein and dural sinus thrombosis in elderly patients. Stroke 36:1927–1932

    PubMed  Google Scholar 

  • Ferro JM, Canhao P, Bousser MG, Stam J, Barinagarrementeria F (2008) Early seizures in cerebral vein and dural sinus thrombosis: risk factors and role of antiepileptics. Stroke 39:1152–1158

    PubMed  Google Scholar 

  • Ferro JM, Canhão P, Stam J et al (2009) Delay in the diagnosis of cerebral vein and dural sinus thrombosis. Influence on outcome. Stroke 40:3133–3138

    PubMed  Google Scholar 

  • Ferro JM, Crassard I, Coutinho JM et al (2011) Decompressive surgery in cerebrovenous thrombosis. A multicenter registry and a systematical review of individual patient data. Stroke 42:2825–2831

    PubMed  Google Scholar 

  • Gosk-Bierska I, Wysokinski W, Brown RD et al (2006) Cerebral venous sinus thrombosis. Incidence of venous thrombosis recurrence and survival. Neurology 67:814–819

    CAS  PubMed  Google Scholar 

  • Haberl R, Aichner F, Baumgartner R et al (2008) Hirnvenen- und Sinusthrombose. In: Diener HC, Putzki N, Berlit P (Hrsg) Kommission „Leitlinien“ der DGN: Leitlinien für Diagnostik und Therapie in der Neurologie, 4. Aufl. Thieme, Stuttgart, S 338–344

    Google Scholar 

  • Herrmann KA, Sporer B, Yousry TA (2004) Thrombosis of the internal cerebral vein associated with transient unilateral thalamic edema: a case report and review of the literature. AJNR Am J Neuroradiol 25:1351–1355

    PubMed  Google Scholar 

  • Idbaih A, Boukobza M, Crassard I et al (2006) MRI of clot in cerebral venous thrombosis. High diagnostic value of susceptibility-weighted images. Stroke 37:991–995

    PubMed  Google Scholar 

  • Jacobs K, Moulin T, Bogousslavsky J et al (1996) The stroke syndrome of cortical vein thrombosis. Neurology 47:376–382

    CAS  PubMed  Google Scholar 

  • Kidwell CS, Wintermark M (2008) Imaging of intracranial haemeorrhage. Lancet Neurol 7:256–267

    PubMed  Google Scholar 

  • Koennecke H-C (2009) Zerebrale Sinus- und Venenthrombose. Fortschr Neurol Psychiatr 77:228–237

    PubMed  Google Scholar 

  • Kosinski CM, Mull M, Schwarz M et al (2004) Do normal D-dimer levels reliably exclude cerebral sinus thrombosis? Stroke 35:2820–2825

    Google Scholar 

  • Kuehnen J, Schwartz A, Neff W et al (1998) Cranial nerve syndrome in thrombosis of the transverse/sigmoid sinuses. Brain 121:381–388

    PubMed  Google Scholar 

  • Lalive PH, de Moerloose P, Lovblad K et al (2003) Is measurement of D-dimer useful in the diagnosis of cerebral venous thrombosis? Neurology 61:1057–1060

    CAS  PubMed  Google Scholar 

  • Leach JL, Fortuna RB, Jones BV et al (2006) Imaging of cerebral venous thrombosis: current techniques, spectrum of findings, and diagnostic pitfalls. Radiographics 26:S19–S43

    PubMed  Google Scholar 

  • Liang L, Korogi Y, Sugahara T et al (2001) Evaluation of the intracranial dural sinuses with a 3D contrast-enhanced MP-RAGE sequence: prospective comparison with 2D-TOF MR venography and digital subtraction angiography. AJNR Am J Neuroradiol 22:481–492

    CAS  PubMed  Google Scholar 

  • Majoie CB, van Straten M, Venema HW et al (2004) Multisection CT venography of the dural sinuses and cerebral veins by using matched mask bone elimination. AJNR Am J Neuroradiol 25:787–791

    PubMed  Google Scholar 

  • Mullins ME, Grant PE, Wang B et al (2004) Parenchymal abnormalities associated with cerebral venous sinus thrombosis: assessment with diffusion-weighted MR imaging. AJNR Am J Neuroradiol 25:1666–1675

    PubMed  Google Scholar 

  • Roth P, Happold C, Eisele G et al (2008) A series of patients with subpial hemorrhage: clinical manifestation, neuroradiological presentation, and therapeutic implications. J Neurol 255:1018–1022

    PubMed  Google Scholar 

  • Schwarz S, Daffertshofer M, Schwarz T et al (2003) Aktuelle Probleme der Diagnostik und Therapie zerebraler Venen- und Sinusthrombosen. Nervenarzt 74:639–651

    CAS  PubMed  Google Scholar 

  • Siddiqui FM, Dandapat S, Banerjee C et al (2015) Mechanical thrombectomy in cerebral venous thrombosis. Systematic review of 185 cases. Stroke 46:1263–1268

    PubMed  Google Scholar 

  • Stam J (2005) Thrombosis of the cerebral veins and sinuses. N Engl J Med 352:1791–1798

    CAS  PubMed  Google Scholar 

  • Stam J, Majoie CBLM, van Delden OM et al (2008) Endovascular thrombectomy and thrombolysis for severe cerebral sinus thrombosis. A prospevctive study. Stroke 39:1487–1490

    PubMed  Google Scholar 

  • Stein PD, Hull RD, Patel KC et al (2004) D-dimer for the exclusion of acute venous thrombosis and pulmonary embolism: a systematic review. Ann Intern Med 140:589–602

    PubMed  Google Scholar 

  • Strupp M, Dichgans M (2007) Sinus- und Hirnvenenthrombosen. In: Brandt T, Dichgans J, Diener HC (Hrsg) Therapie und Verlauf neurologischer Erkrankungen, 5. Aufl. Kohlhammer, Stuttgart, S 478–491

    Google Scholar 

  • Urban PP, Müller-Forell W (2005) Clinical and neuroradiological spectrum of isolated cortical vein thrombosis. J Neurol 252:1476–1481

    PubMed  Google Scholar 

  • de Veber G, Andrew M, Adams C et al (2001) Cerebral sinovenous thrombosis in children. N Engl J Med 345:417–423

    Google Scholar 

  • Wasay M, Bakshi R, Kojan S et al (2001) Nonrandomized comparison of local urokinase thrombolysis versus systemic heparin anticoagulation for superior sagittal sinus thrombosis. Stroke 32:2310–2317

    CAS  PubMed  Google Scholar 

  • Weimar C, Fiehler J, Koennecke HC et al (2012) Zerebrale Sinus- und Venenthrombose. In: Leitlinien für Diagnostik und Therapie in der Neurologie, 5. Aufl. Thieme, Stuttgart, S 398–405

    Google Scholar 

  • Zuurbier SM, Arnold M, Middeldorp S et al (2016) Risk of cerebral venous thrombosis in obese women. JAMA Neurol 73:579–584

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Neurologie – Stroke Unit, Vivantes Klinikum im Friedrichshain, Berlin, Deutschland

    Hans-Christian Koennecke

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  1. Hans-Christian Koennecke
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Correspondence to Hans-Christian Koennecke .

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  1. Deutsche Gesellschaft für Neurologie, Berlin, Germany

    Peter Berlit

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Koennecke, HC. (2020). Zerebrale Sinus- und Venenthrombosen. In: Berlit, P. (eds) Klinische Neurologie. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60676-6_150

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  • DOI: https://doi.org/10.1007/978-3-662-60676-6_150

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-60674-2

  • Online ISBN: 978-3-662-60676-6

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