Skip to main content

Zusammenfassung

Bis in die 70er-Jahre des letzten Jahrhunderts war umstritten, ob und in welchem Ausmaß das Cytosol einer Zelle durch ein Cytoskelett strukturiert ist. Entsprechende faserartige Strukturen in elektronenmikroskopischen Aufnahmen wurden oft für Fixierungsartefakte gehalten. Mit der Einführung immuncytochemischer Methoden gelang dann endgültig der Nachweis, dass eukaryontische Zellen von einem hochstrukturierten Netzwerk aus unterschiedlichen cytosklelettären Elementen durchzogen sind. Diese sind an der dynamischen Organisation von Zellform und -bewegung, der Zellteilung, der Verankerung von Zelladhäsionsproteinen und dem intrazellulären Transport unterschiedlichster membranärer Strukturen beteiligt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 69.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 89.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Weiterführende Literatur

  • Bachmann A, Straube A (2015) Kinesins in cell migration. Biochem Soc Trans 43:79–83

    Article  CAS  PubMed  Google Scholar 

  • Berg KD, Tamas RM, Riemann A et al (2009) Caveolae in fibroblast-like synoviocytes: static structures associated with vimentin-based intermediate filaments. Histochem Cell Biol 131:103–114

    Article  CAS  PubMed  Google Scholar 

  • Blanchoin L, Boujemaa-Paterski R, Sykes C, Plastino J (2014) Actin dynamics, architecture, and mechanics in cell motility. Physiol Rev 94:235–263

    Article  CAS  PubMed  Google Scholar 

  • Chung BM, Rotty JD, Coulombe PA (2013) Networking galore: intermediate filaments and cell migration. Curr Opin Cell Biol 25:600–612

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dey P, Togra J, Mitra S (2014) Intermediate filament: Structure, function, and applications in cytology. Diagn Cytopathol 42:628, Epub ahead of print

    Article  PubMed  Google Scholar 

  • Etienne-Manneville S (2013) Microtubules in cell migration. Annu Rev Cell Dev Biol 29:471–499

    Article  CAS  PubMed  Google Scholar 

  • Etienne-Manneville S (2018) Cytoplasmic intermediate filaments in cell biology. Annu Rev Cell Dev Biol 34:1–28

    Article  CAS  PubMed  Google Scholar 

  • Hermann H, Aebi U (2016) Intermediate filaments: Structure and assembly. Cold Spring Harb Perspect Biol 8:a018242

    Article  Google Scholar 

  • Kneussel M, Wagner W (2013) Myosin motors at neuronal synapses: drivers of membrane transport and actin dynamics. Nat Rev Neurosci 14:233–247

    Article  CAS  PubMed  Google Scholar 

  • Lodish H, Berk A, Kaiser CA, Krieger M, Bretscher A, Ploegh H, Amon A, Martin KC (2016) Molecular cell biology. WH Freeman, New York

    Google Scholar 

  • Mallik R, Rai AK, Barak P, Rai A, Kunwar A (2013) Teamwork in microtubule motors. Trends Cell Biol 23:575–582

    Article  CAS  PubMed  Google Scholar 

  • Masters TA, Kendrick-Jones J, Buss F (2016) Myosins: domain organisation, motor properties, physiological roles and cellular functions. In: Jockusch B (Hrsg) The actin cytoskeleton Handbook of experimental pharmacology, Bd 235. Springer, Cham, S 77–122

    Chapter  Google Scholar 

  • Roberts AJ, Kon T, Knight PJ, Sutoh K, Burgess SA (2013) Functions and mechanics of dynein motor proteins. Nat Rev Mol Cell Biol 14:713–726

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schmidt H, Carter AP (2016) Structure and mechanism of the dynein motor ATPase. Biopolymers 105:557–567

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Lutz Graeve .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2022 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Graeve, L., Müller, M. (2022). Cytoskelett. In: Heinrich, P.C., Müller, M., Graeve, L., Koch, HG. (eds) Löffler/Petrides Biochemie und Pathobiochemie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60266-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-60266-9_13

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-60265-2

  • Online ISBN: 978-3-662-60266-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics