Zusammenfassung
Die vorrangigste Aufgabe der Plazenta ist es, den wachsenden Fetus mit Energie in Form von Nährstoffen und mit Sauerstoff zu versorgen. Auf diese beiden Funktionen wird im folgenden Kapitel im Detail eingegangen. Die Versorgung mit Nährstoffen ist in den Transport von 1) Lipiden und Fettsäuren, 2) Glukose, 3) Proteinen und Aminosäuren sowie 4) den Transport von Spurenelementen und Mineralien untergliedert. Abschließend wird der maternofetale Gasaustausch von Sauerstoff und Kohlendioxid sowie die besonderen Eigenschaften des fetalen Hämoglobins beschrieben.
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Literatur
Arnone A (1972) X-ray diffraction study of binding of 2,3-Diphosphoglycerate to human Deoxyhaemoglobin. Nature 237(5351):146–149
Aslam N, McArdle HJ (1992) Mechanism of zinc uptake by microvilli isolated from human term placenta. J Cell Physiol 151(3). doi: 10.1002/jcp.1041510312
Aynsley-Green A et al (1985) The metabolic and endocrine milieu of the human fetus at 18–21 weeks of gestation. II. Blood glucose, lactate, pyruvate and ketone body concentrations. Biol Neonate 47(1):19–25
Bajoria R et al (2002) Placenta as a link between amino acids, insulin-IGF axis, and low birth weight: Evidence from twin studies. J Clin Endocrinol Metab 87(1):308–315
Barker DJP (1998) In utero programming of chronic disease. Clin Science 95(2):115–128
Beer R, Doll E, Wenner J (1958) Shift in oxygen dissociation curve of the blood of infants in the first month of life. Pflugers Archiv für die gesamte Physiologie des Menschen und der Tiere 265(6):526–540
Belkacemi L et al (2003) Expression of Calbindin-D28k (CaBP28k) in Trophoblasts from Human Term Placenta1. Biol Reprod 68(6):1943–1950
Belkacemi L et al (2005) Calcium channels, transporters and exchangers in placenta: a review. Cell Calcium 37(1):1–8
Benesch R, Benesch RE (1967) The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin. biochemical and biophysical research communications. Biochem Biophys Res Comm 26(2):162–167
Bohr C, Hasselbalch K, Krogh A (1904) Über einen in biologischer Beziehung wichtigen Einfluss, den die Kohlensäurespannung des Blutes auf dessen Sauerstoffbindung übt. Skand Archiv Physiol 16(2):402–412
Bozzetti P et al (1988) The relationship of maternal and fetal glucose concentrations in the human from midgestation until term. Metabolism 37(4):358–363
Buchanan TA et al (1990) Insulin sensitivity and B-cell responsiveness to glucose during late pregnancy in lean and moderately obese women with normal glucose tolerance or mild gestational diabetes. Am J Obstet Gynecol 162(4):1008–1014
Burd LI et al (1975) Placental production and foetal utilisation of lactate and pyruvate. Nature 254(5502):710–711
Catalano PM et al (1991) Incidence and risk factors associated with abnormal postpartum glucose tolerance in women with gestational diabetes. Am J Obstet Gynecol 165(4 Pt 1):914–919
Cetin I et al (2005) Maternal and fetal amino acid concentrations in normal pregnancies and in pregnancies with gestational diabetes mellitus. Am J Obstet Gynecol 192(2):610–617
Challis DE et al (2000) Glucose metabolism is elevated and vascular resistance and maternofetal transfer is normal in perfused placental cotyledons from severely growth-restricted fetuses. Pediatr Res 47(3):309–315
Chanutin A, Curnish RR (1967) Effect of organic and inorganic phosphates on the oxygen equilibrium of human erythrocytes. Arch Biochem Biophys 121(1):96–102
Chubanov V et al (2016) Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5. doi: 10.7554/elife.20914
Cleal JK et al (2007) Modification of fetal plasma amino acid composition by placental amino acid exchangers in vitro. J Physiol 582(2):871–882
Delivoria-Papadopoulos M, McGowan J (2011) Oxygen transport and delivery. In: Polin R, Fox W, Abman S (eds) Fetal and Neonatal Physiology. Elsevier, p 972
Delivoria-Papadopoulos M, Roncevic N, Oski F (1971) Postnatal changes in oxygen transport of term, premature, and sick infants: the role of red cell 2,3-diphosphoglycerate and adult hemoglobin. Pediatr Res 5:235
Desoye G, Gauster M, Wadsack C (2011) Placental transport in pregnancy pathologies. Am J Clin Nutr 94(6):1896–1902
Douglas GC et al (1998) Uptake of 125I-labelled alpha2-macroglobulin and albumin by human placental syncytiotrophoblast in vitro. J Cell Biochem 68(4):427–435
Drakesmith H, Nemeth E, Ganz T (2015) Ironing out ferroportin. Cell Metab 22(5):777–787
Durnwald C et al (2004) Evaluation of body composition of large-for-gestational-age infants of women with gestational diabetes mellitus compared with women with normal glucose tolerance levels. Am J Obstet Gynecol 191(3):804–808
Ericsson A et al (2005) Hormonal regulation of glucose and system A amino acid transport in first trimester placental villous fragments. Am J Physiol Regul Integr Comp Physiol 288(3):R656–662
Finch CA et al (1983) Fetal iron balance in the rat. Am J Clin Nutr 37(6):910–917
Fleming MD et al (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Genetics 95:1148–1153
Ford D (2004) Intestinal and placental zinc transport pathways. Proc Nutr Soc 63(1):21–29
Freinkel N (1980) Banting lecture 1980. Of pregnancy and progeny. Diabetes 29(12):1023–1035
Gauster M et al (2007) Dysregulation of placental endothelial lipase and lipoprotein lipase in intrauterine growth-restricted pregnancies. J Clin Endocrin Metabol 92(6):2256–2263
Gilbert M, Hauguel S, Bouisset M (1984) Uterine blood flow and substrate uptake in conscious rabbit during late gestation. Am J Physiol 247(5 Pt 1):E574–580
Glazier JD et al (1997) Association between the activity of the system A amino acid transporter in the microvillous plasma membrane of the human placenta and severity of fetal compromise in intrauterine growth restriction. Pediatr Res 42(4):514–519
Goyer RA, Haust MD, Cherian MG (1992) Cellular localization of metallothionein in human term placenta. Placenta 13(4):349–355
Haggarty P (2010) Fatty acid supply to the human fetus. Ann Rev Nutr 30(1):237–255
Hahn D et al (2001) From maternal glucose to fetal glycogen: expression of key regulators in the human placenta. Mol Hum Reprod 7(12):1173–1178
Hahn T et al (1995) Localisation of the high affinity facilitative glucose transporter protein GLUT 1 in the placenta of human, marmoset monkey (Callithrix jacchus) and rat at different developmental stages. Cell Tissue Res 280(1):49–57
Hahn T et al (2000) Hyperglycaemia-induced subcellular redistribution of GLUT1 glucose transporters in cultured human term placental trophoblast cells. Diabetologia 43(2):173–180
He Z, Russell J (2001) Expression, purification, and characterization of human hemoglobins Gower-1 (zeta2epsilon2), Gower-2 (alpha2epsilon2), and Portland-2 (zeta2beta2) assembled in complex transgenic-knockout mice. Blood 97(4):1099–1105
Herrera E et al (2006) Maternal lipid metabolism and placental lipid transfer. Horm Res 65(S3):9–64
Herrera E, Desoye G (2016) Maternal and fetal lipid metabolism under normal and gestational diabetic conditions. Horm Mol Biol Clin Investig 26(2):109–127
Hill AV (1910) The possible effects of the aggregation of the molecules of hæmoglobin on its dissociation curves. J Physiol 40(Supplement-Proceedings of the physiological society), iv–vii
Hofmann O, Mould R, Brittain T (1995) Allosteric modulation of oxygen binding to the three human embryonic haemoglobins. Biochem J 306(Pt 2):367–370
Hüfner G von (1889) Ueber krystallinisches Hämaglobin. Zeitschrift für physiolog. Chemie, XI–XIII
Husain SM, Mughal MZ (1992) Mineral transport across the placenta. Arch Dis Child 67:874–878
Innis SM (2005) Essential fatty acid transfer and fetal development. Placenta 26 Suppl A: 70–75
Jansson T et al (2002a) Alterations in the activity of placental amino acid transporters in pregnancies complicated by diabetes. Diabetes 51(7):2214–2219
Jansson T et al (2002b) Glucose transport and system A activity in syncytiotrophoblast microvillous and basal plasma membranes in intrauterine growth restriction. Placenta 23(5):392–399
Jansson T, Powell TL (2006) IFPA 2005 Award in placentology lecture. Human placental transport in altered fetal growth: does the placenta function as a nutrient sensor? – a review. Placenta, 27 Suppl A: 91–97
Jansson T, Scholtbach V, Powell TL (1998) Placental transport of leucine and lysine is reduced in intrauterine growth restriction. Pediatr Res 44(4):532–537
Jansson T, Wennergren M, Illsley NP (1993) Glucose transporter protein expression in human placenta throughout gestation and in intrauterine growth retardation. J Clin Endocrinol Metab 77(6):1554–1562
Kalhan S, Parimi P (2000) Gluconeogenesis in the fetus and neonate. Semin Perinatol 24(2):94–106
Kalhan SC et al (1979) Glucose production in pregnant women at term gestation. sources of glucose for human fetus. J Clin Invest 63(3):388–394
Kolisek M et al (2013) Hypertension in pregnancy SLC41A1 is the only magnesium responsive gene significantly overexpressed in placentas of preeclamptic women. Hypertension in Pregnancy 32(4):378–389
Kovalevsky AY et al (2010) Direct determination of protonation states of histidine residues in a 2 A neutron structure of deoxy-human normal adult hemoglobin and implications for the Bohr effect. J Mol Biol 398(2):276–291
Kudo Y, Boyd CAR (2001) Characterisation of L-tryptophan transporters in human placenta: a comparison of brush border and basal membrane vesicles. J Physiol 531(2):405–416
Lafond J et al (2001) Hormonal regulation and implication of cell signaling in calcium transfer by placenta. Endocrine 14(3):285–294
Lafond J et al (1988) Parathyroid hormone receptor in human placental syncytiotrophoblast brush border and basal plasma membranes. Endocrinology 123(6):2834–2840
Lajeunesse D, Brunette MG (1988) Sodium gradient-dependent phosphate transport in placental brush border membrane vesicles. Placenta 9(2):117–128
Leitner Y, Fattal-Valevski a, Geva R, Eshel R, Toledano-Alhadef H, Rotstein M, Bassane H, Radianu B, Bitchonsky O, Jaffa aJ et al (2007) Neurodevelopmental outcome of children with intrauterine growth retardation: a longitudinal, 10-Year prospective study. J Child Neurol 22:580–587
Lourdes M et al (1992) Effect of chronic maternal dietary magnesium deficiency on placental calcium transport. J Am Coll Nutr 11(1):87–92
Mahendran D et al (1993) Amino acid (system A) transporter activity in microvillous membrane vesicles from the placentas of appropriate and small for gestational age babies. Pediatr Res 34(5):661–665
Mas A, Sarkar B (1991) Binding, uptake and efflux of 65Zn by isolated human trophoblast cells. BBA - Molecular Cell Research 1092(1):35–38
Maymon R et al (2000) Localization of p43 placental isoferritin in human maternal-fetal tissue interface. Am J Obstet Gynecol 182(3):670–674
Moreau R et al (2003) Expression and role of calcium-ATPase pump and sodium-calcium exchanger in differentiated trophoblasts from human term placenta. Molecular Reproduction and Development 65(3):283–288
Morriss FH et al (1974) The glucose/oxygen quotient of the term human fetus. Biol Neonate 25(1–2):44–52
Nelson DM et al (2003) Hypoxia reduces expression and function of system A amino acid transporters in cultured term human trophoblasts. AJP: CellPhysiology 284(2):C310–C315
Nishimura M, Naito S (2008) Tissue-specific mRNA expression profiles of human solute carrier transporter superfamilies. Drug Metab Pharmacokinet 23(1):22–44
Ohgami RS et al (2006) The steap proteins are metalloreductases. Blood 108(4):1388–1394
Okamoto Y et al (2002) Expression and regulation of 4F2hc and hLAT1 in human trophoblasts. Am J Physiol Cell Physiol 282(1):C196–204
Osmond DT et al (2001) Placental glucose transport and utilisation is altered at term in insulin-treated, gestational-diabetic patients. Diabetologia 44(9):1133–1139
Paolini CL et al (2001) Placental transport of leucine, phenylalanine, glycine, and proline in intrauterine growth-restricted pregnancies. J Clin Endocrinol Metab 86(11):5427–5432
Perutz MF (1964) The hemoglobin molecule. Sci Am 211:64–76
Perutz MF (1970) Stereochemistry of cooperative effects in haemoglobin. Nature 228:726–734
Pinilla-Tenas JJ et al (2011) Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. AJP: Cell Physiology 301(4):C862–C871
Ponka P, Lok CN (1999) The transferrin receptor: role in health and disease. Int J Biochem Cell Biol 31(10):1111–1137
Roos S et al (2007) Mammalian target of rapamycin in the human placenta regulates leucine transport and is down-regulated in restricted fetal growth. J Physiol 582(1):449–459
Salle B et al (1987) Vitamin D metabolism in preterm infants. Biol Neonate 52:119–130
Schauberger CW, Pitkin RM (1979) Maternal-perinatal calcium relationships. Obstet Gynecol 53(1):74–76
Shibata E et al (2006) Angiotensin II decreases system A amino acid transporter activity in human placental villous fragments through AT1 receptor activation. Am J Physiol Endocrinol Metab 291(5):E1009–1016
Sibley CP, Boyd RD (1988) Control of transfer across the mature placenta. Ox Rev Reprod Biol 10:382–435
Tjoelker LW et al (1994) Human, mouse, and rat calnexin cDNA cloning: identification of potential calcium binding motifs and gene localization to human chromosome 5. Biochemistry 33(11):3229–3236
Tobin JD, Roux JF, Soeldner JS (1969) Human fetal insulin response after acute maternal glucose administration during labor. Pediatrics 44(5):668–671
Voets T et al (2004) TRPM6 forms the Mg2+ influx channel involved in intestinal and renal Mg2+ absorption. J Biol Chem 279(1):19–25
Wang CY et al (2012) ZIP8 is an iron and zinc transporter whose cell-surface expression is up-regulated by cellular iron loading. J Biol Chem 287(41):34032–34043
Waterman IJ et al (2000) Further characterization of a novel triacylglycerol hydrolase activity (pH 6.0 optimum) from microvillous membranes from human term placenta. Placenta 21(8):813–823
Whaley WH, Zuspan FP, Nelson GH (1966) Correlation between maternal and fetal plasma levels of glucose and free fatty acids. Am J Obstet Gynecol 94(3):419–421
Xing AY et al (1998) Unexpected expression of glucose transporter 4 in villous stromal cells of human placenta. J Clin Endocrinol Metab 83(11):4097–4101
Yang H et al (2014) Comparing the expression patterns of placental magnesium/phosphorus-transporting channels between healthy and preeclamptic pregnancies. Mol Reprod Dev 81(9):851–860
Zhang Y et al (2003) The cooperativity of human fetal and adult hemoglobins is optimized: a consideration based on the effectiveness of the Bohr shift. Zoolog Sci 20(1):23–28
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Gruber, M., Hirschmugl, B., Schliefsteiner, C., Wadsack, C. (2018). Plazentafunktion – Nährstofftransport – Gasaustausch. In: Huppertz, B., Schleußner, E. (eds) Die Plazenta. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-55622-1_4
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