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An Electrochemical Transdermal Patch for Permeation Enhancement

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Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement

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Abstract

A novel electrochemical patch is described that works by the hydrolysis of water in a hydrogel between two suitable electrodes that produces a strongly enhanced drug flux through the skin. This non-iontophoretic mechanism requires only a short voltage application (60 s) yet produces enhanced skin permeation over up to 5 h. In this chapter the design and formulation of the patch are reviewed. The results of an in vivo study on humans are also discussed in terms of a comparison with iontophoretic patches.

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Authors and Affiliations

  1. Division of Pharmaceutics, Friedrich-Alexander-University Erlangen, Erlangen, Germany

    Geoffrey Lee & Ulrich Nickel

  2. Acino AG, Miesbach, Germany

    Britta Schröder & Elisabeth Meyer

Authors
  1. Geoffrey Lee
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  2. Britta Schröder
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  3. Ulrich Nickel
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  4. Elisabeth Meyer
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Corresponding author

Correspondence to Geoffrey Lee .

Editor information

Editors and Affiliations

  1. Apoteka “Beograd”, Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Lee, G., Schröder, B., Nickel, U., Meyer, E. (2017). An Electrochemical Transdermal Patch for Permeation Enhancement. In: Dragicevic, N., I. Maibach, H. (eds) Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-53273-7_9

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  • DOI: https://doi.org/10.1007/978-3-662-53273-7_9

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-53271-3

  • Online ISBN: 978-3-662-53273-7

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