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Liposomes as Drug Delivery Systems in Dermal and Transdermal Drug Delivery

  • Chapter
Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement

Abstract

This chapter reviews the background, development, and application of liposomes as dermal drug delivery system, methods for their production and characterization, and possible ways of interaction of liposomes with the skin.

Liposomes resemble cell membranes in their structure and composition. They are typically made from natural lipids and can encapsulate or bind a variety of drug molecules into or onto their membranes. Consequently, all these properties make them attractive candidates for use as drug delivery vehicles.

Today, numerous lab scales, but only a few large-scale techniques for producing liposomes, are available. However, a lot of these methods have serious limitations in terms of entrapment of sensitive molecules due to their exposure to mechanical and/or chemical stress. This chapter summarizes laboratory and industrial techniques for liposome production and their limitations.

Liposome applications in dermal/transdermal drug delivery depend on physicochemical characteristics, such as size, composition, loading efficiency, and the stability of the carrier as well as their biological interactions with the skin cells. The application of liposomes on the skin surface has been proven to be effective in drug delivery into the skin. Liposomes increase the permeability of skin for various entrapped drugs and at the same time diminish the side effects of these drugs because lower doses are now required. The use of liposomes in cosmetology also has many benefits, including improved penetration and diffusion of active ingredients, selective transport of active ingredients, longer release time, greater stability of active ingredients, reduction of unwanted side effects, and high biocompatibility.

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Authors and Affiliations

  1. Department of Biotechnology, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000, Belgrade, Serbia

    Slavica Siler-Marinkovic

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  1. Slavica Siler-Marinkovic
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Correspondence to Slavica Siler-Marinkovic .

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  1. Department of Manufacturing, Apoteka "Beograd", Belgrade, Serbia

    Nina Dragicevic

  2. San Francisco, California, USA

    Howard I. Maibach

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Siler-Marinkovic, S. (2016). Liposomes as Drug Delivery Systems in Dermal and Transdermal Drug Delivery. In: Dragicevic, N., Maibach, H. (eds) Percutaneous Penetration Enhancers Chemical Methods in Penetration Enhancement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47862-2_2

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