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Molecular Principles of Adhesion and Biofilm Formation

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Book cover The Root Canal Biofilm

Part of the book series: Springer Series on Biofilms ((BIOFILMS,volume 9))

Abstract

Oral bacteria are responsible for oral health and disease, including caries, periodontal disease, and endodontic infections. The development of oral diseases is intimately linked with the ability of oral bacteria to form and reside in an adherent multispecies consortium named biofilm. The oral biofilm provides a protective environment for the bacterial community and its formation is a genetically controlled process. In this chapter, we present a general overview of developmental mechanisms employed by individual members of the oral biofilm. The species composition of the oral biofilm and the oral microbiome is discussed historically and in the context of newly developed next-generation sequencing techniques. Furthermore, biofilm-specific regulatory mechanisms and phenotypic traits are explained to provide the reader with a comprehensive overview of oral biofilm formation and its role in health and disease.

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Acknowledgments

Research in the authors’ labs that is referred to in this chapter was supported by NIH-NIDCR R01DE021726, R00DE018400 and R03DE022601 (JK) and R01DE08590 (MCH).

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

    Jens Kreth

  2. Department of Diagnostic and Biological Sciences, School of Dentistry, Mucosal and Vaccine Research Center, Minneapolis VA Medical Center, University of Minnesota, Minneapolis, MN, USA

    Mark C. Herzberg

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  1. Jens Kreth
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Correspondence to Jens Kreth .

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Editors and Affiliations

  1. The Swedish Academy for Advanced Clinical Dentistry, Gothenburg, Sweden

    Luis E. Chávez de Paz

  2. Endodontology, Oregon Health & Science University, Portland, Oregon, USA

    Christine M. Sedgley

  3. Department of Clinical Sciences Discipline of Endodontics, The University of Toronto Faculty of Dentistry, Toronto, Ontario, Canada

    Anil Kishen

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Kreth, J., Herzberg, M.C. (2015). Molecular Principles of Adhesion and Biofilm Formation. In: Chávez de Paz, L., Sedgley, C., Kishen, A. (eds) The Root Canal Biofilm. Springer Series on Biofilms, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47415-0_2

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