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Pathomechanisms of Photoaged Skin

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Textbook of Aging Skin

Abstract

Solar UV radiation is the most important in premature skin aging (photoaging). From resent research, it is now clear that both UVB (290–320 nm) and UVA (320–400 nm) radiations contribute to photoaging. UV-induced alterations at the level of the dermis are best studied and appear to be largely responsible for the phenotype of photoaged skin. It is also generally agreed that UVB acts preferentially on the epidermis where it not only damages DNA in keratinocytes and melanocytes but also causes the production of soluble factors including proteolytic enzymes, which in a second step affect the dermis; in contrast, UVA radiation penetrates far more deeply and exerts direct effects on both the epidermal and the dermal compartments. UVA radiation may be at least as important as UVB radiation in the pathogenesis of photoaging.

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Acknowledgments

Part of the work described in this chapter has been supported by the DFG, SFB 728.

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Authors and Affiliations

  1. Environmental Health Research Institute (IUF), Heinrich-Heine-University, Auf’m Hennekamp 50, D-40225, Duesseldorf, Germany

    Jean Krutmann

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  1. Jean Krutmann
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Correspondence to Jean Krutmann .

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Editors and Affiliations

  1. Winton Hill Business Center, The Procter & Gamble Company , Cincinnati, Ohio, USA

    Miranda A. Farage

  2. Margoshes-Miller Consulting, LLC, Cincinnati, Ohio, USA

    Kenneth W. Miller

  3. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Krutmann, J. (2017). Pathomechanisms of Photoaged Skin. In: Farage, M., Miller, K., Maibach, H. (eds) Textbook of Aging Skin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47398-6_10

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  • DOI: https://doi.org/10.1007/978-3-662-47398-6_10

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47397-9

  • Online ISBN: 978-3-662-47398-6

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