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miRNA Optical Detection

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MicroRNA Detection and Pathological Functions

Part of the book series: SpringerBriefs in Molecular Science ((BRIEFSMOLECULAR))

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Abstract

miRNA is a kind of attractive candidates, as biomarkers, for early cancer diagnosis. Therefore, simple and novel strategies for miRNA detection with high sensitivity and selectivity have great significance not only for the studies of its biological functions but also for clinical cancer diagnosis. Various reliable optical miRNA detection methods have become a class of attractive and paramount for miRNA expression analysis, due to its high sensitivity, wide dynamic range, and multiplexing capabilities. The progress of nanotechnology and nanoscience allows nanomaterial-based signal amplification to develop highly sensitive and selective biosensors for in situ or online detection of miRNA. Molecular biology-based strategies for miRNA detection by amplifying the target or probe with high detection sensitivity are applied in identifying and detecting nucleic acids analysis.

Haifeng Dong and Xiangdan Meng contributed together to this chapter.

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Authors and Affiliations

  1. Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, China

    Xueji Zhang, Haifeng Dong & Yaping Tian

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  1. Xueji Zhang
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  2. Haifeng Dong
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  3. Yaping Tian
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Correspondence to Xueji Zhang .

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Zhang, X., Dong, H., Tian, Y. (2015). miRNA Optical Detection. In: MicroRNA Detection and Pathological Functions. SpringerBriefs in Molecular Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47293-4_5

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