Abstract
Pemphigoid gestationis is a rare autoimmune blistering disease of pregnancy involving autoantibodies targeting collagen XVII in the basement membrane zone of the skin. Patients usually present with pruritic urticarial papules and annular plaques eventually developing vesicles and tense bullae ranging from a few days to 4 weeks. The most common site for the lesions is the periumbilical area. Diagnosis is made by a high clinical suspicion on presentation and confirmed by histology and direct immunofluorescence. If required, indirect immunofluorescence, enzyme-linked immunosorbent assay, and immunoblotting may be done. Current management includes topical and systemic steroids, anti-inflammatory antibiotics, and immunosuppressives.
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Mendoza, C.G., Black, M.M., Murrell, D.F. (2015). Current Management of Pemphigoid Gestationis. In: Murrell, D. (eds) Blistering Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45698-9_56
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DOI: https://doi.org/10.1007/978-3-662-45698-9_56
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