Skip to main content
SpringerLink
Log in

Adnextumoren mit Talgdrüsen- und Haarfollikeldifferenzierung

  • Chapter
  • First Online:
Histopathologie der Haut

Part of the book series: Springer Reference Medizin ((SRM))

Zusammenfassung

Hauttumoren mit Talgdrüsen- und Haarfollikeldifferenzierung sind gekennzeichnet durch ihre Komplexität und eine verwirrende Nomenklatur. Viele dieser Läsionen weisen eine ausgeprägte Variabilität ihres histologischen Erscheinungsbildes auf. Die Histogenese kutaner Adnextumoren ist bei Weitem nicht vollkommen verstanden. Bei manchen Tumoren gewinnt man den Eindruck, dass sie sich von bestehenden Adnexstrukturen ableiten. Eine alternative, ebenfalls gültige Sichtweise geht jedoch davon aus, dass sich Hautanhangstumoren eher in Richtung einer oder mehrerer kutaner Adnexstrukturen differenzieren als von ihnen per se direkt abzustammen. Bei der Differenzierung mancher Tumoren scheint die embryologische Entwicklung der korrespondierenden ursprünglichen Adnexstrukturen erneut durchlaufen zu werden.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 589.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 599.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Weiterführende Literatur

  • Ackerman AB, Böer A (2008) Histopathologic diagnosis of adnexal epithelial neoplasms. Ardor Scribendi, New York

    Google Scholar 

  • Ackerman BA, Reddy VB, Soyer PH (2001) Neoplasms with follicular differentiation. Ardor Scribendi, New York

    Google Scholar 

  • Ackerman AB, Nussen-Lee S, Aldrene Tan ML (2009) Histopathologic diagnosis of neoplasms with sebaceous differentiation. Ardor Scribendi, New York

    Google Scholar 

  • Kazakov DV, Michal M, Kacerovska D, McKee PH (2012) Cutaneous adnexal tumors. Lippincott William&Wilkins, Philadelphia

    Google Scholar 

  • LeBoit PE, Burg G, Weedon D et al (2006) World Health Organization classification of tumours. Pathology and genetics of skin tumours. IARC Press, Lyon

    Google Scholar 

  • Requena L (2004) Neoplasias anexiales cutaneas. Aulo Medico Ediciones, Madrid

    Google Scholar 

  • Steffen C, Ackerman AB (1994) Neoplasms with sebaceous differentiation. Lea&Febiger, Philadelphia

    Google Scholar 

Weiterführende Literatur zu Talgdrüsenadenom

  • Brownstein MH, Shapiro L (1977) The pilosebaceous tumors. Int J Dermatol 16:340–352

    Google Scholar 

  • Prioleau PG, Santa Cruz DJ (1984) Sebaceous gland neoplasia. J Cutan Pathol 11:396–414

    Article  CAS  PubMed  Google Scholar 

  • Rulon DB, Helwig EB (1974) Cutaneous sebaceous neoplasms. Cancer 33:82–102

    Article  CAS  PubMed  Google Scholar 

  • Sachez Yus E, Requena L, Simon P et al (1995) Sebomatricoma: a unifying term that encompasses all benign neoplasms with sebaceous differentiation. Am J Dermatopathol 17:213–221

    Article  CAS  PubMed  Google Scholar 

  • Shalin SC, Lyle S, Calonje E et al (2010) Sebaceous neoplasia and the Muir-Torre syndrome: important connections with clinical implications. Histopathology 56:133–147

    Article  PubMed  PubMed Central  Google Scholar 

Weiterführende Literatur zu Sebazeom

  • Dinneen AM, Mehregan DR (1996) Sebaceous epithelioma: a review of twenty-one cases. J Am Acad Dermatol 34:47–50

    Article  CAS  PubMed  Google Scholar 

  • Fan YS, Carr RA, Sanders DS et al (2007) Characteristic Ber-EP4 and EMA expression in sebaceoma is immunohistochemically distinct from basal cell carcinoma. Histopathology 51:80–86

    Article  CAS  PubMed  Google Scholar 

  • Kazakov DV, Kutzner H, Rutten A et al (2005) Carcinoid-like pattern in sebaceous neoplasms: another distinctive, previously unrecognized pattern in extraocular sebaceous carcinoma and sebaceoma. Am J Dermatopathol 27:195–203

    Article  PubMed  Google Scholar 

  • Kazakov DV, Calonje E, Rutten A et al (2007) Cutaneous sebaceous neoplasms with a focal glandular pattern (seboapocrine lesions): a clinicopathological study of three cases. Am J Dermatopathol 29:359–364

    Google Scholar 

  • Misago N, Mihara I, Ansai S et al (2002) Sebaceoma and related neoplasms with sebaceous differentiation: a clinicopathologic study of 30 cases. Am J Dermatopathol 24:294–304

    Article  PubMed  Google Scholar 

  • Troy JL, Ackerman AB (1984) Sebaceoma. A distinctive benign neoplasm of adnexal epithelium differentiating toward sebaceous cells. Am J Dermatopathol 6:7–13

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zu retikuläres Akanthom mit Talgdrüsendifferenzierung

  • Friedman KJ, Boudreau S, Farmer ER (1987) Superficial epithelioma with sebaceous differentiation. J Cutan Pathol 14:193–197

    Article  CAS  PubMed  Google Scholar 

  • Fukai K, Sowa J, Ishii M (2006) Reticulated acanthoma with sebaceous differentiation. Am J Dermatopathol 28:158–161

    Article  PubMed  Google Scholar 

  • Haake DL, Minni JP, Nowak M et al (2009) Reticulated acanthoma with sebaceous differentiation. Lack of association with Muir-Torre syndrome. Am J Dermatopathol 31:391–392

    Article  PubMed  Google Scholar 

  • Leboeuf NR, Mahalingam M (2007) Acanthomatous superficial sebaceous hamartoma? A study of six cases with clarification of the nomenclature. J Cutan Pathol 34:865–870

    Article  PubMed  Google Scholar 

Weiterführende Literatur zum Talgdrüsenkarzinom

  • Boniuk M, Zimmerman LE (1972) Sebaceous carcinoma of the eyelid, eyebrow, caruncle and orbit. Int Ophthalmol Clin 12:225–257

    CAS  PubMed  Google Scholar 

  • Dasgupta T, Wilson LD, Yu JB (2009) A retrospective review of 1349 cases of sebaceous carcinoma. Cancer 115:158–165

    Article  PubMed  Google Scholar 

  • Dores GM, Curtis RE, Toro JR et al (2008) Incidence of cutaneous sebaceous carcinoma and risk of associated neoplasms: insight into Muir-Torre syndrome. Cancer 113:3372–3381

    Article  PubMed  PubMed Central  Google Scholar 

  • Kazakov DV, Kutzner H, Spagnolo DV, Rutten A, Mukensnabl P, Michal M (2009) Discordant architectural and cytological features in cutaneous sebaceous neoplasms – a classification dilemma: report of 5 cases. Am J Dermatopathol 31:31–36

    Google Scholar 

  • Kazakov DV, Kutzner H, Spagnolo DV, Rutten A, Mukensnabl P, Michal M (2010a) What is extraocular cutaneous sebaceous carcinoma in situ? Am J Dermatopathol 32:857–858

    Article  PubMed  Google Scholar 

  • Kazakov DV, Spagnolo DV, Kacerovska D, Michal M (2010b) Unusual patterns of cutaneous sebaceous neoplasms. Diagn Histopathol 16:425–431

    Article  Google Scholar 

  • Rao NA, Hidayat AA, McLean IW et al (1982) Sebaceous carcinomas of the ocular adnexa: a clinicopathologic study of 104 cases, with five-year follow-up data. Hum Pathol 13:113–122

    Article  CAS  PubMed  Google Scholar 

  • Shields JA, Demirci H, Marr BP et al (2004) Sebaceous carcinoma of the eyelids: personal experience with 60 cases. Ophthalmology 111:2151–2157

    Article  PubMed  Google Scholar 

  • Shields JA, Demirci H, Marr BP et al (2005) Sebaceous carcinoma of the ocular region: a review. Surv Ophthalmol 50:103–122

    Article  PubMed  Google Scholar 

  • Wick MR, Goellner JR, Wolfe JT 3rd et al (1985) Adnexal carcinomas of the skin. II. Extraocular sebaceous carcinomas. Cancer 56:1163–1172

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zum Mantelom

  • Kacerovska D, Kazakov DV, Michal M (2010a) Spindle-cell predominant trichodiscoma with a palisaded arrangement of stromal cells. Am J Dermatopathol 32:743–744

    Article  PubMed  Google Scholar 

  • Kacerovska D, Michal M, Kazakov DV (2010b) Trichodiscoma with lipomatous metaplasia and pleomorphic stromal cells. J Cutan Pathol 37:1110–1111

    Article  PubMed  Google Scholar 

  • Kutzner H, Requena L, Rutten A et al (2006) Spindle cell predominant trichodiscoma: a fibrofolliculoma/trichodiscoma variant considered formerly to be a neurofollicular hamartoma: a clinicopathological and immunohistochemical analysis of 17 cases. Am J Dermatopathol 28:1–8

    Article  PubMed  Google Scholar 

  • Misago N, Kimura T, Narisawa Y (2009) Fibrofolliculoma/trichodiscoma and fibrous papule (perifollicular fibroma/angiofibroma): a revaluation of the histopathological and immunohistochemical features. J Cutan Pathol 36:943–951

    Article  PubMed  Google Scholar 

  • Pinkus H, Coskey R, Burgess GH (1974) Trichodiscoma. A benign tumor related to haarscheibe (hair disk). J Invest Dermatol 63:212–218

    Article  CAS  PubMed  Google Scholar 

  • Schulz T, Hartschuh W (1999) Birt-Hogg-Dube syndrome and Hornstein-Knickenberg syndrome are the same. Different sectioning technique as the cause of different histology. J Cutan Pathol 26:55–61

    Article  CAS  PubMed  Google Scholar 

  • Starink TM, Kisch LS, Meijer CJ (1985) Familial multiple trichodiscomas. A clinicopathologic study. Arch Dermatol 121:888–891

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zum Steatozystom

  • Cho S, Chang SE, Choi JH et al (2002) Clinical and histologic features of 64 cases of steatocystoma multiplex. J Dermatol 29:152–156

    Article  PubMed  Google Scholar 

  • Covello SP, Smith FJ, Sillevis Smitt JH et al (1998) Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2. Br J Dermatol 139:475–480

    Article  CAS  PubMed  Google Scholar 

  • Munro CS, Carter S, Bryce S et al (1994) A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21. J Med Genet 31:675–678

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Tomkova H, Fujimoto W, Arata J (1997) Expression of keratins (K10 and K17) in steatocystoma multiplex, eruptive vellus hair cysts, and epidermoid and trichilemmal cysts. Am J Dermatopathol 19:250–253

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zu Nävus sebaceus (Jadassohn)

  • Alessi E, Sala F (1986) Nevus sebaceus. A clinicopathologic study of its evolution. Am J Dermatopathol 8:27–31

    Article  CAS  PubMed  Google Scholar 

  • Cribier B, Scrivener Y, Grosshans E (2000) Tumors arising in nevus sebaceus: a study of 596 cases. J Am Acad Dermatol 42:263–268

    Article  CAS  PubMed  Google Scholar 

  • Happle R (2010) The group of epidermal nevus syndromes Part I. Well defined phenotypes. J Am Acad Dermatol 63:1–22

    Article  PubMed  Google Scholar 

  • Jaqueti G, Requena L, Sanchez YE (2000) Trichoblastoma is the most common neoplasm developed in nevus sebaceus of Jadassohn: a clinicopathologic study of a series of 155 cases. Am J Dermatopathol 22:108–118

    Article  CAS  PubMed  Google Scholar 

  • Kaddu S, Schaeppi H, Kerl H et al (2000) Basaloid neoplasms in nevus sebaceus. J Cutan Pathol 27:327–337

    Article  CAS  PubMed  Google Scholar 

  • Kazakov DV, Calonje E, Zelger B et al (2007) Sebaceous carcinoma arising in nevus sebaceus of Jadassohn: a clinicopathological study of five cases. Am J Dermatopathol 29:242–248

    Google Scholar 

  • Kazakov DV, Requena L, Kutzner H et al (2010) Morphologic diversity of syringocystadenocarcinoma papilliferum based on a clinicopathologic study of 6 cases and review of the literature. Am J Dermatopathol 32:340–347

    Google Scholar 

  • Levinsohn JL, Tian LC, Boyden LM, McNiff JM, Narayan D, Loring ES et al (2013) Whole-exome sequencing reveals somatic mutations in HRAS and KRAS, which cause nevus sebaceus. J Invest Dermatol 133:827–830

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mehregan AH, Pinkus H (1965) Life history of organoid nevi. Special reference to nevus sebaceus of Jadassohn. Arch Dermatol 91:574–588

    Article  CAS  PubMed  Google Scholar 

  • Wilson Jones E, Hely T (1970) Nevus sebaceus. A report of 140 cases with special regard to the development of secondary malignant tumours. Br J Dermatol 82:99–117

    Article  Google Scholar 

Weiterführende Literatur zur Talgdrüsenhyperplasie

  • de Berker DA, Taylor AE, Quinn AG et al (1996) Sebaceous hyperplasia in organ transplant recipients: shared aspects of hyperplastic and dysplastic processes? J Am Acad Dermatol 35:696–699

    Article  PubMed  Google Scholar 

  • Fernandez N, Torres A (1984) Hyperplasia of sebaceous glands in a linear pattern of papules. Report of four cases. Am J Dermatopathol 6:237–243

    Article  CAS  PubMed  Google Scholar 

  • Finan MC, Apgar JT (1991) Juxta-clavicular beaded lines: a subepidermal proliferation of sebaceous gland elements. J Cutan Pathol 18:464–468

    Article  CAS  PubMed  Google Scholar 

  • Schirren CG, Jansen T, Lindner A et al (1996a) Diffuse sebaceous gland hyperplasia. A case report and an immunohistochemical study with cytokeratins. Am J Dermatopathol 18:296–301

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zur Talgdrüsen-Induktion

  • Requena L, Roo E, Sanchez Yus E (1992) Plate-like sebaceous hyperplasia overlying dermatofibroma. J Cutan Pathol 19:253–255

    Google Scholar 

  • Shuweiter M, Böer A (2009) Spectrum of follicular and sebaceous differentiation induced by dermatofibroma. Am J Dermatopathol 31:778–785

    Article  PubMed  Google Scholar 

Weiterführende Literatur zum follikulär-zystischen Talgdrüsenhamartom

  • Ansai S, Kimura T, Kawana S (2010) A clinicopathologic study of folliculosebaceous cystic hamartoma. Am J Dermatopathol 32:815–820

    Article  PubMed  Google Scholar 

  • Cole P, Kaufman Y, Dishop M et al (2008) Giant, congenital folliculosebaceous cystic hamartoma: a case against a pathogenetic relationship with trichofolliculoma. Am J Dermatopathol 30:500–503

    Article  PubMed  Google Scholar 

  • Plewig G (1980) Sebaceous trichofolliculoma. J Cutan Pathol 7:394–403

    Article  CAS  PubMed  Google Scholar 

  • Schulz T, Hartschuh W (1998) Folliculo-sebaceous cystic hamartoma is a trichofolliculoma at its very late stage. J Cutan Pathol 25:354–364

    Google Scholar 

  • Wu YH (2008) Folliculosebaceous cystic hamartoma or trichofolliculoma? A spectrum of hamartomatous changes inducted by perifollicular stroma in the follicular epithelium. J Cutan Pathol 35:843–848

    Article  PubMed  Google Scholar 

Weiterführende Literatur zu ektopen Talgdrüsen

  • Ackerman AB, Penneys NS (1971) Montgomery’s tubercles. Sebaceous glands. Obstet Gynecol 38:924–927

    CAS  PubMed  Google Scholar 

  • Belousova IE, Kazakov DV, Michal M (2005) Ectopic sebaceous glands in the vagina. Int J Gynecol Pathol 24:193–195

    Article  PubMed  Google Scholar 

  • Brady A, McCluggage WG (2013) Ectodermal structures within the uterine cervix and vagina: report of a series of cases. Int J Gynecol Pathol 32:602–605

    Article  PubMed  Google Scholar 

  • Daley T (1993) Pathology of intraoral sebaceous glands. J Oral Pathol Med 22:241–245

    Article  CAS  PubMed  Google Scholar 

  • Kazakov DV, Hejda V, Kacerovska D et al (2010) Hyperplasia of ectopic sebaceous glands in the uterine cervix: case report. Int J Gynecol Pathol 29:605–608

    Google Scholar 

  • Kazakov DV, Mukensnabl P, Kacerovska D et al (2009) Mantle structures in the uterine cervix. Int J Gynecol Pathol 28:568–569

    Google Scholar 

Weiterführende Literatur zur Talgdrüsendifferenzierung in anderen Adnextumoren

  • Kazakov DV, Belousova IE, Bisceglia M et al (2007) Apocrine mixed tumor of the skin („mixed tumor of the folliculosebaceous-apocrine complex“). Spectrum of differentiations and metaplastic changes in the epithelial, myoepithelial, and stromal components based on a histopathologic study of 244 cases. J Am Acad Dermatol 57:467–483

    Google Scholar 

  • Kazakov DV, Kutzner H, Spagnolo DV et al (2008) Sebaceous differentiation in poroid neoplasms: report of 11 cases, including a case of metaplastic carcinoma associated with apocrine poroma (sarcomatoid apocrine porocarcinoma). Am J Dermatopathol 30:21–26

    Article  PubMed  Google Scholar 

  • Kazakov DV, Spagnolo DV, Kacerovska D et al (2011) Cutaneous type adnexal tumors outside the skin. Am J Dermatopathol 33:303–315

    Google Scholar 

  • Requena L, Sanchez Yus E, Santa Cruz DJ (1992) Apocrine type of cutaneous mixed tumor with follicular and sebaceous differentiation. Am J Dermatopathol 14:186–194

    Google Scholar 

Weiterführende Literatur zum Trichoblastom

  • Brooke JD, Fitzpatrick JE, Golitz LE (1989) Papillary mesenchymal bodies: a histologic finding useful in differentiating trichoepitheliomas from basal cell carcinomas. J Am Acad Dermatol 21:523–528

    Article  CAS  PubMed  Google Scholar 

  • Brownstein MH, Shapiro L (1977) Desmoplastic trichoepithelioma. Cancer 40:2979–2986

    Google Scholar 

  • Brownstein MH, Starink TM (1987) Desmoplastic trichoepithelioma and intradermal nevus: a combined malformation. J Am Acad Dermatol 17:489–492

    Article  CAS  PubMed  Google Scholar 

  • Headington JT (1976) Tumors of the hair follicle. A review. Am J Pathol 85:479–514

    CAS  PubMed  PubMed Central  Google Scholar 

  • Kazakov DV, Mentzel T, Erlandson RA et al (2006) Clear cell trichoblastoma: a clinicopathological and ultrastructural study of two cases. Am J Dermatopathol 28:197–201

    Article  PubMed  Google Scholar 

  • Kazakov DV, Vanecek T, Zelger B et al (2011) Multiple (familial) trichoepitheliomas: a clinicopathological and molecular biological study, including CYLD and PTCH gene analysis, of a series of 16 patients. Am J Dermatopathol 33:251–265

    Google Scholar 

  • Long SA, Hurt MA, Santa Cruz DJ (1988) Immature trichoepithelioma: report of six cases. J Cutan Pathol 15:353–358

    Article  CAS  PubMed  Google Scholar 

  • Requena L, Sanchez Yus E (1992) Cutaneous lymphadenoma with ductal differentiation. J Cutan Pathol 19:429–433

    Article  CAS  PubMed  Google Scholar 

  • Rodriguez-Diaz E, Roman C, Yuste M et al (1998) Cutaneous lymphadenoma: an adnexal neoplasm with intralobular activated lymphoid cells. Am J Dermatopathol 20:74–78

    Article  CAS  PubMed  Google Scholar 

  • Santa Cruz DJ, Barr RJ, Headington JT (1991) Cutaneous lymphadenoma. Am J Surg Pathol 15:101–110

    Article  CAS  PubMed  Google Scholar 

  • Takei Y, Fukushiro S, Ackerman AB (1985) Criteria for histologic differentiation of desmoplastic trichoepithelioma (sclerosing epithelial hamartoma) from morphea-like basal-cell carcinoma. Am J Dermatopathol 7:207–221

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zum Pilomatrixom

  • Fender AB, Reale VF, Scott GA (2008) Anetodermic pilomatricoma with perforation. J Am Acad Dermatol 58:535–536

    Article  PubMed  Google Scholar 

  • Forbis R Jr, Helwig EB (1961) Pilomatrixoma (calcifying epithelioma). Arch Dermatol 83:606–618

    Article  PubMed  Google Scholar 

  • Julian CG, Bowers PW (1998) A clinical review of 209 pilomatricomas. J Am Acad Dermatol 39:191–195

    Article  CAS  PubMed  Google Scholar 

  • Kaddu S, Beham-Schmid C, Soyer HP et al (1995) Extramedullary hematopoiesis in pilomatricomas. Am J Dermatopathol 17:126–130

    Article  CAS  PubMed  Google Scholar 

  • Kaddu S, Soyer HP, Cerroni L et al (1994) Clinical and histopathologic spectrum of pilomatricomas in adults. Int J Dermatol 33:705–708

    Article  CAS  PubMed  Google Scholar 

  • Kaddu S, Soyer HP, Hodl S et al (1996) Morphological stages of pilomatricoma. Am J Dermatopathol 18:333–338

    Article  CAS  PubMed  Google Scholar 

  • Kaddu S, Soyer HP, Wolf IH et al (1997) Proliferating pilomatricoma. A histopathologic simulator of matrical carcinoma. J Cutan Pathol 24:228–234

    Article  CAS  PubMed  Google Scholar 

  • Kazakov DV, Sima R, Vanecek T et al (2009) Mutations in exon 3 of the CTNNB1 gene (beta-catenin gene) in cutaneous adnexal tumors. Am J Dermatopathol 31:248–255

    Google Scholar 

  • Lozzi GP, Soyer HP, Fruehauf J et al (2007) Giant pilomatricoma. Am J Dermatopathol 29:286–289

    Article  PubMed  Google Scholar 

  • Pujol RM, Casanova JM, Egido R et al (1995) Multiple familial pilomatricomas: a cutaneous marker for Gardner syndrome? Pediatr Dermatol 12:331–335

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zum melanozytären Matrixom

  • Carlson JA, Healy K, Slominski A et al (1999) Melanocytic matricoma: a report of two cases of a new entity. Am J Dermatopathol 21:344–349

    Article  CAS  PubMed  Google Scholar 

  • Tallon B, Cerroni L (2010) Where pigmented pilomatricoma and melanocytic matricoma collide. Am J Dermatopathol 32(8):769–773

    Article  PubMed  Google Scholar 

Weiterführende Literatur zum Pilomatrixkarzinom

  • Hardisson D, Linares MD, Cuevas-Santos J et al (2001) Pilomatrix carcinoma: a clinicopathologic study of six cases and review of the literature. Am J Dermatopathol 23:394–401

    Article  CAS  PubMed  Google Scholar 

  • Lazar AJ, Calonje E, Grayson W et al (2005) Pilomatrix carcinomas contain mutations in CTNNB1, the gene encoding beta-catenin. J Cutan Pathol 32:148–157

    Article  PubMed  Google Scholar 

  • Monteagudo C, Fernandez-Figueras MT, San Juan J et al (2003) Matrical carcinoma with prominent melanocytic hyperplasia (malignant melanocytic matricoma?) A report of two cases. Am J Dermatopathol 25:485–489

    Article  PubMed  Google Scholar 

  • Sau P, Lupton GP, Graham JH (1993) Pilomatrix carcinoma. Cancer 71:2491–2498

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zum Trichilemmon

  • Ackerman AB, Wade TR (1980) Tricholemmoma. Am J Dermatopathol 2:207–224

    Article  CAS  PubMed  Google Scholar 

  • Brownstein MH (1980) Trichilemmoma. Benign follicular tumor or viral wart? Am J Dermatopathol 2:229–231

    Article  CAS  PubMed  Google Scholar 

  • Brownstein MH, Shapiro L (1973) Trichilemmoma. Analysis of 40 new cases. Arch Dermatol 107:866–869

    Article  CAS  PubMed  Google Scholar 

  • Brownstein MH, Mehregan AH, Bikowski JB et al (1979) The dermatopathology of Cowden’s syndrome. Br J Dermatol 100:667–673

    Article  CAS  PubMed  Google Scholar 

  • Hunt SJ, Kilzer B, Santa Cruz DJ (1990) Desmoplastic trichilemmoma: histologic variant resembling invasive carcinoma. J Cutan Pathol 17:45–52

    Article  CAS  PubMed  Google Scholar 

  • Schaller J, Rohwedder A, Burgdorf WH et al (2003) Identification of human papillomavirus DNA in cutaneous lesions of Cowden syndrome. Dermatology 207:134–140

    Article  CAS  PubMed  Google Scholar 

  • Stierman S, Chen S, Nuovo G, Thomas J (2010) Detection of human papillomavirus infection in trichilemmomas and verrucae using in situ hybridization. J Cutan Pathol 37(1):75–80

    Article  PubMed  Google Scholar 

Weiterführende Literatur zum trichilemmalen Horn

  • Haro R, Gonzalez-Guerra E, Farina MC, Martin-Moreno L, Requena L (2009) Trichilemmal horn: a new case and review of the literature. Actas Dermosifiliogr 100:65–68

    Article  CAS  PubMed  Google Scholar 

  • Michal M, Bisceglia M, Di Mattia A, Requena L, Fanburg-Smith JC, Mukensnabl P, Hes O, Cada F (2002) Gigantic cutaneous horns of the scalp: lesions with a gross similarity to the horns of animals: a report of four cases. Am J Surg Pathol 26:789–794

    Article  PubMed  Google Scholar 

Weiterführende Literatur zu trichilemmalem Karzinom

  • Dalton SR, LeBoit PE (2008) Squamous cell carcinoma with clear cells: how often is there evidence of tricholemmal differentiation? Am J Dermatopathol 30:333–339

    Article  PubMed  Google Scholar 

  • Headington JT (1992) Tricholemmal carcinoma. J Cutan Pathol 19:83–84

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zum Tumor des follikulären Infundibulums

  • Abbas O, Mahalingam M (2009) Tumor of the follicular infundibulum: an epidermal reaction pattern? Am J Dermatopathol 31:626–633

    Google Scholar 

  • Alomari A, Subtil A, Owen CE, McNiff JM (2013) Solitary and multiple tumors of follicular infundibulum: a review of 168 cases with emphasis on staining patterns and clinical variants. J Cutan Pathol 40:532–537

    Article  PubMed  Google Scholar 

  • Cribier B, Grosshans E (1995) Tumor of the follicular infundibulum: a clinicopathologic study. J Am Acad Dermatol 33:979–984

    Article  CAS  PubMed  Google Scholar 

  • Weyers W, Horster S, Diaz-Cascajo C (2009) Tumor of follicular infundibulum is basal cell carcinoma. Am J Dermatopathol 31:634–641

    Article  PubMed  Google Scholar 

Weiterführende Literatur zum Haarscheidenakanthom

Weiterführende Literatur zum proliferierenden Trichilemmaltumor

  • Brownstein MH, Arluk DJ (1981) Proliferating trichilemmal cyst: a simulant of squamous cell carcinoma. Cancer 48:1207–1214

    Article  CAS  PubMed  Google Scholar 

  • Folpe AL, Reisenauer AK, Mentzel T et al (2003) Proliferating trichilemmal tumors: clinicopathologic evaluation is a guide to biologic behavior. J Cutan Pathol 30:492–498

    Article  PubMed  Google Scholar 

  • Haas N, Audring H, Sterry W (2002) Carcinoma arising in a proliferating trichilemmal cyst expresses fetal and trichilemmal hair phenotype. Am J Dermatopathol 24:340–344

    Article  PubMed  Google Scholar 

  • Mori O, Hachisuka H, Sasai Y (1990) Proliferating trichilemmal cyst with spindle cell carcinoma. Am J Dermatopathol 12:479–484

    Article  CAS  PubMed  Google Scholar 

  • Sau P, Graham JH, Helwig EB (1995) Proliferating epithelial cysts. Clinicopathological analysis of 96 cases. J Cutan Pathol 22:394–406

    Article  CAS  PubMed  Google Scholar 

  • Ye J, Nappi O, Swanson PE et al (2004) Proliferating pilar tumors: a clinicopathologic study of 76 cases with a proposal for definition of benign and malignant variants. Am J Clin Pathol 122:566–574

    Article  PubMed  Google Scholar 

Weiterführende Literatur zum Trichoadenom

  • Rahbari H, Mehregan A, Pinkus H (1977) Trichoadenoma of Nikolowski. J Cutan Pathol 4:90–98

    Article  CAS  PubMed  Google Scholar 

  • Reibold R, Undeutsch W, Fleiner J (1998) Trichoadenoma of Nikolowski – review of four decades and seven new cases. Hautarzt 49:925–928

    Article  CAS  PubMed  Google Scholar 

  • Shimanovich I, Krahl D, Rose C (2010) Trichoadenoma of Nikolowski is a distinct neoplasm within the spectrum of follicular tumors. J Am Acad Dermatol 62:277–283

    Article  PubMed  Google Scholar 

Weiterführende Literatur zum Nävus comedonicus

  • Nabai H, Mehregan AH (1973) Nevus comedonicus. A review of the literature and report of twelve cases. Acta Derm Venereol 53:71–74

    CAS  PubMed  Google Scholar 

  • Resnik KS, Kantor GR, Howe NR et al (1993) Dilated pore nevus. A histologic variant of nevus comedonicus. Am J Dermatopathol 15:169–171

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zur dilatierten Pore

  • Klovekorn G, Klovekorn W, Plewig G, Pinkus H (1983) Giant pore and hair-shaft acanthoma. Clinical and histologic diagnosis. Hautarzt 34:209–216

    CAS  PubMed  Google Scholar 

  • Mehregan AH (1984) Infundibular tumors of the skin. J Cutan Pathol 11:387–395

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zum Trichofollikulom

  • Gray HR, Helwig EB (1962) Trichofolliculoma. Arch Dermatol 86:619–625

    Article  Google Scholar 

  • Misago N, Kimura T, Toda S et al (2010) A revaluation of trichofolliculoma: the histopathological and immunohistochemical features. Am J Dermatopathol 32:35–43

    Article  PubMed  Google Scholar 

  • Pinkus H, Sutton RL Jr (1965) Trichofolliculoma. Arch Dermatol 91:46–49

    Article  CAS  PubMed  Google Scholar 

  • Schulz T, Hartschuh W (1998) The trichofolliculoma undergoes changes corresponding to the regressing normal hair follicle in its cycle. J Cutan Pathol 25:341–353

    Google Scholar 

Weiterführende Literatur zum Panfollikulom

  • Kacerovska D, Michal M, Kazakov DV (2012) Panfolliculoma with sebaceous differentiation – a case report. Am J Dermatopathol 34:e90–e93

    Google Scholar 

  • Schirren CG, Rütten A, Plewig G (1996) Das Panfollikulom. Hautarzt 47:610–615

    Google Scholar 

Weiterführende Literatur zur fibrösen Papel

  • Bansal C, Stewart D, Li A et al (2005) Histologic variants of fibrous papule. J Cutan Pathol 32:424–428

    Article  PubMed  Google Scholar 

  • Guitart J, Bergfeld WF, Tuthill RJ (1991) Fibrous papule of the nose with granular cells: two cases. J Cutan Pathol 18:284–287

    Article  CAS  PubMed  Google Scholar 

  • Jacyk WK, Rutten A, Requena L (2008) Fibrous papule of the face with granular cells. Dermatology 216:56–59

    Article  CAS  PubMed  Google Scholar 

  • Kacerovska D, Vrtel R, Michal M, Vanecek T, Vodicka R, Kreuzberg B, Ricarova R, Pizinger K, Danis D, Reischig T, Kazakov DV (2009) TSC2/PKD1 contiguous gene syndrome: a report of 2 cases with emphasis on dermatopathologic findings. Am J Dermatopathol 31(6):532–541

    Google Scholar 

  • Kacerovska D, Kerl K, Michal M, Filipova H, Vrtel R, Vanecek T, Zelenakova H, Kraus J, Kodet R, Kazakov DV (2012) Giant angiofibromas in tuberous sclerosis complex: a possible role for localized lymphedema in their pathogenesis. J Am Acad Dermatol 67(6):1319–1326

    Google Scholar 

  • Meigel WN, Ackerman AB (1979) Fibrous papule of the face. Am J Dermatopathol 1:329–340

    Article  CAS  PubMed  Google Scholar 

  • Rosen LB, Suster S (1988) Fibrous papules. A light microscopic and immunohistochemical study. Am J Dermatopathol 10:109–115

    Article  CAS  PubMed  Google Scholar 

  • Soyer HP, Kutzner H, Metze D et al (1997) Fibrous papule with clear fibrocytes. Dermatopathol Pract Concept 3:110–113

    Google Scholar 

Weiterführende Literatur zur basaloiden follikulären Hyperplasie

  • Requena L, Farina MC, Robledo M, Sangueza OP, Sanchez E, Villanueva A, Marquina A, Tamarit R (1999) Multiple hereditary infundibulocystic basal cell carcinomas: a genodermatosis different from nevoid basal cell carcinoma syndrome. Arch Dermatol 135:1227–1235

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zu Haarfollikel-Induktion

  • Dalziel K, Marks R (1986) Hair follicle-like change over histiocytomas. Am J Dermatopathol 8:462–466

    Article  CAS  PubMed  Google Scholar 

  • Kacerovska D, Michal M, Kazakov DV (2009) For Valentine’s Day: adnexal induction over dermatofibroma. Int J Surg Pathol 17:452–453

    Google Scholar 

  • Kacerovska D, Requena L, Michal M, Grossmann P, Treskova I, Roucka P, Kazakov DV (2012) Spectrum of cutaneous and soft tissue lesions in two Carney complex patients-adnexal induction versus authentic adnexal neoplasms. Am J Dermatopathol 34:729–736

    Google Scholar 

  • Morgan MB, Howard HG, Everett MA (1997) Epithelial induction in dermatofibroma: a role for the epidermal growth factor (EGF) receptor. Am J Dermatopathol 19:35–40

    Article  CAS  PubMed  Google Scholar 

  • Requena L, Yus ES, Simon P, del Rio E (1996) Induction of cutaneous hyperplasias by altered stroma. Am J Dermatopathol 18:248–268

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zum Birt-Hogg-Dubé-Syndrom

  • Birt AR, Hogg GR, Dube WJ (1977) Hereditary multiple fibrofolliculomas with trichodiscomas and acrochordons. Arch Dermatol 113:1674–1677

    Article  CAS  PubMed  Google Scholar 

  • Menko FH, van Steensel MA, Giraud S et al (2009) Birt-Hogg-Dube syndrome: diagnosis and management. Lancet Oncol 10:1199–1206

    Article  CAS  PubMed  Google Scholar 

  • Pavlovich CP, Walther MM, Eyler RA et al (2002) Renal tumors in the Birt-Hogg-Dube syndrome. Am J Surg Pathol 26:1542–1552

    Article  PubMed  Google Scholar 

  • Rongioletti F, Hazini R, Gianotti G et al (1989) Fibrofolliculomas, tricodiscomas and acrochordons (Birt-Hogg-Dube) associated with intestinal polyposis. Clin Exp Dermatol 14:72–74

    Article  CAS  PubMed  Google Scholar 

  • Schaffer JV, Gohara MA, McNiff JM et al (2005) Multiple facial angiofibromas: a cutaneous manifestation of Birt-Hogg-Dube syndrome. J Am Acad Dermatol 53:108–111

    Article  Google Scholar 

  • Schmidt LS, Warren MB, Nickerson ML et al (2001) Birt-Hogg-Dube syndrome, a genodermatosis associated with spontaneous pneumothorax and kidney neoplasia, maps to chromosome 17p11.2. Am J Hum Genet 69:876–882

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schulz T, Hartschuh W (2000) Characteristics of the Birt-Hogg-Dube/Hornstein-Knickenberg syndrome. Am J Dermatopathol 22:293–294

    Article  CAS  PubMed  Google Scholar 

  • Toro JR, Pautler SE, Stewart L et al (2007) Lung cysts, spontaneous pneumothorax, and genetic associations in 89 families with Birt-Hogg-Dube syndrome. Am J Respir Crit Care Med 175:1044–1053

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Toro JR, Wei MH, Glenn GM et al (2008) BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dube syndrome: a new series of 50 families and a review of published reports. J Med Genet 45:321–331

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ubogy-Rainey Z, James WD, Lupton GP et al (1987) Fibrofolliculomas, trichodiscomas, and acrochordons: the Birt-Hogg-Dube syndrome. J Am Acad Dermatol 16:452–457

    Article  CAS  PubMed  Google Scholar 

  • Vincent A, Farley M, Chan E et al (2003) Birt-Hogg-Dube syndrome: a review of the literature and the differential diagnosis of firm facial papules. J Am Acad Dermatol 49:698–705

    Article  PubMed  Google Scholar 

Weiterführende Literatur zum Brooke-Spiegler-Syndrom

  • Bignell GR, Warren W, Seal S et al (2000) Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet 25:160–165

    Article  CAS  PubMed  Google Scholar 

  • Bowen S, Gill M, Lee DA et al (2005) Mutations in the CYLD gene in Brooke-Spiegler syndrome, familial cylindromatosis, and multiple familial trichoepithelioma: lack of genotype-phenotype correlation. J Invest Dermatol 124:919–920

    Article  CAS  PubMed  Google Scholar 

  • Grossmann P, Vanecek T, Steiner P, Kacerovska D, Spagnolo DV, Cribier B, Rose C, Vazmitel M, Carlson JA, Emberger M, Martinek P, Pearce RL, Pearn J, Michal M, Kazakov DV (2013) Novel and recurrent germline and somatic mutations in a cohort of 67 patients from 48 families with Brooke-Spiegler syndrome including the phenotypic variant of multiple familial trichoepitheliomas and correlation with the histopathologic findings in 379 biopsy specimens. Am J Dermatopathol 35:34–44

    Google Scholar 

  • Kazakov DV, Zelger B, Rutten A et al (2009) Morphologic diversity of malignant neoplasms arising in preexisting spiradenoma, cylindroma, and spiradenocylindroma based on the study of 24 cases, sporadic or occurring in the setting of Brooke-Spiegler syndrome. Am J Surg Pathol 33:705–719

    Google Scholar 

  • Kazakov DV, Thoma-Uszynski S, Vanecek T et al (2009) A case of Brooke-Spiegler syndrome with a novel germline deep intronic mutation in the CYLD gene leading to intronic exonization, diverse somatic mutations, and unusual histology. Am J Dermatopathol 31:664–673

    Google Scholar 

  • Kazakov DV, Vanecek T, Nemcova J et al (2009) Spectrum of tumors with follicular differentiation in a patient with the clinical phenotype of multiple familial trichoepitheliomas: a clinicopathological and molecular biological study, including analysis of the CYLD and PTCH genes. Am J Dermatopathol 31:819–827

    Google Scholar 

  • Nonaka D, Rosai J, Spagnolo D et al (2004) Cylindroma of the breast of skin adnexal type: a study of 4 cases. Am J Surg Pathol 28:1070–1075

    Article  PubMed  Google Scholar 

  • Puig L, Nadal C, Fernandez-Figueras MT et al (1998) Brooke-Spiegler syndrome variant: segregation of tumor types with mixed differentiation in two generations. Am J Dermatopathol 20:56–60

    Article  CAS  PubMed  Google Scholar 

  • Saggar S, Chernoff KA, Lodha S et al (2008) CYLD mutations in familial skin appendage tumours. J Med Genet 45:298–302

    Article  CAS  PubMed  Google Scholar 

  • Sima R, Vanecek T, Kacerovska D et al (2010) Brooke-Spiegler syndrome: report of 10 patients from 8 families with novel germline mutations: evidence of diverse somatic mutations in the same patient regardless of tumor type. Diagn Mol Pathol 19:83–91

    Article  PubMed  Google Scholar 

Weiterführende Literatur zum Cowden-Syndrom

  • Nelen MR, Padberg GW, Peeters EA, Lin AY, van den Helm B, Frants RR, Coulon V, Goldstein AM, van Reen MM, Easton DF, Eeles RA, Hodgsen S, Mulvihill JJ, Murday VA, Tucker MA, Mariman EC, Starink TM, Ponder BA, Ropers HH, Kremer H, Longy M, Eng C (1996) Localization of the gene for Cowden disease to chromosome 10q22-23. Nat Genet 13:114–116

    Article  CAS  PubMed  Google Scholar 

  • Nelen MR, Kremer H, Konings IB, Schoute F, van Essen AJ, Koch R, Woods CG, Fryns JP, Hamel B, Hoefsloot LH, Peeters EA, Padberg GW (1999) Novel PTEN mutations in patients with Cowden disease: absence of clear genotype-phenotype correlations. Eur J Hum Genet 7:267–273

    Article  CAS  PubMed  Google Scholar 

  • Requena L, Gutierrez J, Sanchez Yus E (1992) Multiple sclerotic fibromas of the skin. A cutaneous marker of Cowden’s disease. J Cutan Pathol 19:346–351

    Google Scholar 

  • Starink TM (1984) Cowden’s disease: analysis of fourteen new cases. J Am Acad Dermatol 11:1127–1141

    Article  CAS  PubMed  Google Scholar 

  • Starink TM, Hausman R (1984) The cutaneous pathology of facial lesions in Cowden’s disease. J Cutan Pathol 11:331–337

    Article  CAS  PubMed  Google Scholar 

Weiterführende Literatur zum Muir-Torre-Syndrom

  • Abbas O, Mahalingam M (2009) Cutaneous sebaceous neoplasms as markers of Muir-Torre syndrome: a diagnostic algorithm. J Cutan Pathol 36:613–619

    Google Scholar 

  • Burgdorf WH, Pitha J, Fahmy A (1986) Muir-Torre syndrome. Histologic spectrum of sebaceous proliferations. Am J Dermatopathol 8:202–208

    Article  CAS  PubMed  Google Scholar 

  • Cesinaro AM, Ubiali A, Sighinolfi P et al (2007) Mismatch repair proteins expression and microsatellite instability in skin lesions with sebaceous differentiation: a study in different clinical subgroups with and without extracutaneous cancer. Am J Dermatopathol 29:351–358

    Article  PubMed  Google Scholar 

  • Kacerovska D, Cerna K, Martinek P, Grossmann P, Michal M, Ricar J, Kazakov DV (2012) MSH6 mutation in a family affected by Muir-Torre syndrome. Am J Dermatopathol 34:648–652

    Google Scholar 

  • Kruse R, Rütten A, Lamberti C et al (1998) Muir-Torre phenotype has a frequency of DNA mismatch-repair-gene mutations similar to that in hereditary nonpolyposis colorectal cancer families defined by the Amsterdam criteria. Am J Hum Genet 63:63–70

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kruse R, Rutten A, Schweiger N et al (2003) Frequency of microsatellite instability in unselected sebaceous gland neoplasias and hyperplasias. J Invest Dermatol 120:858–864

    Article  CAS  PubMed  Google Scholar 

  • Lee BA, Yu L, Ma L, Lind AC, Lu D (2012) Sebaceous neoplasms with mismatch repair protein expressions and the frequency of co-existing visceral tumors. J Am Acad Dermatol 67:1228–1234

    Article  CAS  PubMed  Google Scholar 

  • Mangold E, Pagenstecher C, Leister M et al (2004) A genotype-phenotype correlation in HNPCC: strong predominance of msh2 mutations in 41 patients with Muir-Torre syndrome. J Med Genet 41:567–572

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Rutten A, Burgdorf W, Hugel H et al (1999) Cystic sebaceous tumors as marker lesions for the Muir-Torre syndrome: a histopathologic and molecular genetic study. Am J Dermatopathol 21:405–413

    Article  CAS  PubMed  Google Scholar 

  • South CD, Hampel H, Comeras I et al (2008) The frequency of Muir-Torre syndrome among Lynch syndrome families. J Natl Cancer Inst 100:277–281

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Šikl´s Department of Pathology, Charles University Hospital and Medical Faculty, Pilsen, Tschechien

    D. Kazakov

Authors
  1. D. Kazakov
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to D. Kazakov .

Editor information

Editors and Affiliations

  1. Universitätsklinik für Dermatologie, Medizinische Universität Graz, Graz, Austria

    Lorenzo Cerroni

  2. Universitäts-Hautklinik, Eberhard-Karls-Universität, Tübingen, Germany

    Claus Garbe

  3. Universitäts-Hautklinik Münster, Münster, Germany

    Dieter Metze

  4. Dermatopathologie Friedrichshafen, Friedrichshafen, Germany

    Heinz Kutzner

  5. Universitätsklinik für Dermatologie und, Medizinische Universität Graz, Graz, Steiermark, Austria

    Helmut Kerl

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Kazakov, D. (2016). Adnextumoren mit Talgdrüsen- und Haarfollikeldifferenzierung. In: Cerroni, L., Garbe, C., Metze, D., Kutzner, H., Kerl, H. (eds) Histopathologie der Haut. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45133-5_31

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-45133-5_31

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-45132-8

  • Online ISBN: 978-3-662-45133-5

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation