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Specification of Body Axes and Localized Fate Allotment by External and Maternal Cues

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Development and Reproduction in Humans and Animal Model Species

Abstract

In the course of embryonic development all cells are allocated the entire genetic information, as cell divisions are based on mitotic cell cycles. In the S phase of the cell cycle the DNA is faithfully replicated; the two daughter cells obtain the exact identical genetic information since mitochondria are also apportioned to both cells. Initially there is genomic equivalence, that is the cells of an embryo are initially genetically identical and totipotent (=capable of giving rise to any cell type; proof: nuclear transplantations, Chap. 13).

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Mueller, W.A., Hassel, M., Grealy, M. (2015). Specification of Body Axes and Localized Fate Allotment by External and Maternal Cues. In: Development and Reproduction in Humans and Animal Model Species. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-43784-1_9

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