Abstract
In this study, we report the establishment of lymphocyte cultures from liver allograft biopsies, and correlate their primed lymphocyte testing (PLT) specificity towards HLA class I and/or class II donor antigens with clinicopathological findings. Early posttransplant biopsies generally yielded more class I-specific cells than later biopsies. There appears to be no correlation of hepatocellular enzyme levels (SGOT or SGPT) with PLT specificity. However, the levels of GGTP and AP, which are biliary enzymes, were increased in patients whose biopsies yielded class II-specific rather than class I-specific cells. There was also a trend towards more damage to bile duct epithelium in biopsies yielding class II-specific cells. These results are probably related to the interaction of class II-specific T cells with bile duct epithelium, which has been shown to express class II HLA antigens.
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© 1989 Springer Science+Business Media New York
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Saidman, S. et al. (1989). Role of HLA Class II-Specific Alloreactive T Cells in Biliary Epithelium Injury Associated with Liver Transplant Rejection. In: Dupont, B. (eds) Immunobiology of HLA. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-39946-0_232
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DOI: https://doi.org/10.1007/978-3-662-39946-0_232
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