Abstract
The biosynthesis of hydroxamic acids containing δ-N-hydroxyornithine has now been investigated and appears to proceed by reactions analogous to those in hadacidin biosynthesis. Thus, we have found that δ-N-hydroxyornithine is incorporated into ferrichrome and ferrichrome A by Ustilago sphaerogena to an extent of 35–50% in six hour periods. Ornithine is incorporated to approximately one-half the extent as its δ-hydroxylamino derivative under identical conditions. δ-N-Acetyl-δ-N-hydroxyornithine, the hydroxamic acid subunit of ferrichrome, was found to be a precursor of ferrichrome but not ferrichrome A, in which the acyl groups of the hydroxamate functions are β-methylglutaconate instead of acetate.
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Emery, T. et al. (1967). Addenda. In: Gottlieb, D., Shaw, P.D. (eds) Biosynthesis. Antibiotics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38441-1_33
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