Abstract
Actithiazic acid was discovered and isolated concurrently in four different laboratories. Names proposed for the organisms producing the antibiotic were Streptomyces virginiae (Grundy et al., 1952) S. acidomyceticus (Miyake et al., 1953 a), S. lavendulae (Tejera et al., 1952), and S. cinnamonensis (Maeda et al., 1953). Synonyms for actithiazic acid are acidomycin, cinnamonin and mycobacidin.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Clark, JR., R. K., and J. R. Schenck: Actithiazic acid. Iii. The synthesis of DL-actithiazic acid, derivatives of homologs. Arch. Biochem. 40, 270 (1952).
Grundy, W. E., A. L. Whitman, E. G. Rdzok, E. J. Rdzok, M. E. Hanes, and J. C. Sylvester: Actithiazic acid. I. Microbiological studies. Antibiotics Chemotherapy 2, 399 (1952).
Grundy, W. E., A. L. Whitman, J. C. Sylvester, J. R. Schenck, and A. F. Derose: 4-thiazolidone-2-n-caproic acid and salts and methods of preparing. U.S. Patent Office 2,678, 929 (1954).
Hamada, Y., M. Kawashima, A. Milake, and K. Okamota: Antiacidomycin factor in rabbits urine oberved by cylinder plate method. J. Antibiotics (Japan), Ser. A 6, 158 (1953).
Hwang, K.: Actithiazic acid. IV. Pharmacological studies. Antibiotics Chemotherapy 2, 453 (1952).
Kawashima, M., and S. Fop’: Acidomycin. II. Increase of urinary biotin excretion of acidomycin-tested rabbits. Pharm. Bull. (Tokyo) 1, 328 (1953).
Kawashima, M., Y. Hamada, and S. FuJii: Acidomycin. VI. Metabolic antagonism with biotin. Pharm. Bull. (Tokyo) 1, 94 (1953).
Kawashima, M., A. Miyake, T. Hemmi, and S. Fujii: Acidomycin. Iii. Antibiotin activity of acidomycin and its related compounds. Pharm. Bull. (Tokyo) 4, 53 (1956).
Maeda, K.: Chemical studies on antibiotic substances. Iii. An antimycobacterial antibiotic produced by Streptomyces cinnamonensis. J.pan J. Med. Sci. Biol. 6, 143 (1953).
Mclamore, W. M., W. D. Celmer, V. V. Bogert, F. C. Pennington, B. A. Sobin, and I. A. Solomons: Structure and synthesis of a new, thiazolidone antibiotic. J. Am. Chem. Soc. 75, 105 (1953).
Miyake, A.: Antibiotic. II. Acidomycin. Antitubercular activity of compounds related to acidomycin. Pharm. Bull. (Tokyo) 1, 89 (1953).
Miyake, A., A. Morimato, and T. Kinoshita: Antibiotics. I. Acidomycin. Isolation and chemical structure. Pharm. Bull. (Tokyo) 1, 84 (1953).
Pittillo, R. F., and J. W. Foster: Potentiation of inhibitor action through determination of reversing metabolites. J. Bacteriol. 67, 53 (1954).
Schenck, J. R., and A. F. Derose: Actithiazic acid. II. Isolation and characterization. Arch. Biochem. Biophys. 40, 263 (1952).
Sobin, B. A.: A new streptomyces antibiotic. J. Am. Chem. Soc. 74, 2947 (1952)
Stim, T. B., B. C. Arnwine, and J. W. Foster: Further studies on potentiation of inhibitor action through determination of reversing metabolites. J. Bacteriol. 77, 566 (1959).
Tejera, E., E. J. Backus, M. Dann, C. D. Ervin, A. J. Shakofski, S. O. Thomas, N. BoHoNos, and J. H. Williams: Mycobacidin: An antibiotic active against acid-fast organism. Antibiotics Chemotherapy 2, 333 (1952).
Umezawa, H., K. Oikawa, K. Maeda, and Y. Okami: Antibiotin activity of thiazolidone antibiotic. J.pan J. Med. Sci. Biol. 6, 395 (1953).
Umezawa, H., K. Oikawa, Y. Okami, and K. Maeda • Thiazolidone antibiotic as an antimetabolite to biotin. J. Bacteriol. 66, 118 (1953).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1967 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Caltrider, P.G. (1967). Actithiazic Acid. In: Gottlieb, D., Shaw, P.D. (eds) Antibiotics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38439-8_53
Download citation
DOI: https://doi.org/10.1007/978-3-662-38439-8_53
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-37649-2
Online ISBN: 978-3-662-38439-8
eBook Packages: Springer Book Archive