Abstract
Gougerotin was first isolated as a water soluble, basic antibiotic from culture filtrates of Streptomyces gougerotii, No. 21544 by workers at Takeda Chemical Industries, Ltd., Osaka, Japan (Kanzaki et al., 1962). Gougerotin was found to be a broad spectrum antibiotic of only limited commercial value due to its weak antibiotic activity and toxicity to mammalian systems (Table 1). The I.V. LD50 in mice is 57 mg/kg.
Supported in part by United States Public Health Service Grant, GM 08647.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
References
Casjens, S. R., and A. J. Morris: The selective inhibition of protein assembly by gougerotin. Biochim. et Biophys. Acta 108, 677 (1965).
Clark, JR., J. M., and J. K. Gunther: Gougerotin, a specific inhibitor of protein synthesis. Biochim. et Biophys. Acta 76, 636 (1963).
Clark, JR., J. M., and A. Y. Chang: Inhibitors of the transfer of amino acids from aminoacyl soluble ribonucleic acid to proteins. J. Biol. Chem. 240, 4734 (1965).
Fox, J. J., Y. Kuwada, K. A. Watanabe, T. Ueda, and E. B. Whipple: Nucleosides. Xxv. Chemistry of gougerotin. Antimicrobial agents and chemotherapy (ed. J. C. Sylvester), p. 519. Am. Soc. Microbiol., 1964.
Iwasaki, H.: Studies on the structure of gougerotin, 11 structure of gougerotin. Yakagaku Zasshi 82, 1393 (1962).
Kanzaki, T., E. Higashide, H. Yamamoto, M. Shibata, K. Nakazawa, H. Iwasaki, T. Takewaka, and A. Miyake: Gougerotin, a new antibacterial antibiotic. J. Antibiotics (Japan), Ser. A 15, 93 (1962).
Morris, A., R. Arlinghaus, S. Favelukes, and R. Schweet: Inhibition of hemoglobin synthesis by puromycin. Biochemistry 2, 1084 (1963).
Sinohara, H., and H. H. Sky-Peck: Effect of gougerotin on the protein synthesis in the mouse liver. Biochem. Biophys. Research. Commun. 18, 98 (1965).
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1967 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Clark, J.M. (1967). Gougerotin. In: Gottlieb, D., Shaw, P.D. (eds) Antibiotics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-38439-8_20
Download citation
DOI: https://doi.org/10.1007/978-3-662-38439-8_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-37649-2
Online ISBN: 978-3-662-38439-8
eBook Packages: Springer Book Archive