Abstract
Natural infection of adult mice with reovirus type 3 is asymptomatic. Infection of neonatal mice can result in runting, emaciation, jaundice, bilirubinuria, conjunctivitis, incoordination, tremor, paralysis, and oily hair effect. Survivors are runted with transient alopecia, which is most marked along the dorsum of the head, neck, and rear legs. Yellow or blood-tinged peritoneal exudate can be present. Livers are enlarged and dark, with multiple sharply demarcated yellow foci up to 3 mm in diameter on all surfaces. Gallbladders are distended with dark bile. The intestines are reddened and distended with yellow digesta. Fibrinous exudate and small gray foci have been observed on the epicardium. Other lesions include general pallor, focal pulmonary hemorrhages, pale kidneys, and atrophy of thymus, lymph nodes, and spleen.
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Barthold, S.W. (1997). Reovirus Type 3 Infection, Liver, Mouse. In: Jones, T.C., Popp, J.A., Mohr, U. (eds) Digestive System. Monographs on Pathology of Laboratory Animals, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-25996-2_28
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DOI: https://doi.org/10.1007/978-3-662-25996-2_28
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