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The Red Blood Cell and Nitric Oxide

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 1999

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 1999))

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Abstract

Primary intracellular targets for the biological actions of nitric oxide (NO) are iron and heme-containing proteins [1]. Quantitatively, the major reaction of NO in vivo is with oxyhemoglobin [2]. Therefore, while NO and red blood cells (RBCs) share a close relationship, little is known about specific interactions, such as the impact of NO on oxygen delivery (DO2), on the modulation of RBC membrane properties, on the endothelium’s permeability and on the regulation of blood flow and pressure. In this chapter, we will introduce the reader to three specific areas of NO- and RBC-interactions namely:

  1. 1)

    how NO changes membrane properties of the RBC

  2. 2)

    the dependence of NO modulation of pulmonary vascular resistance (PVR) on the RBC

  3. 3)

    the intracellular machinery that permits the RBC to produce its own NO.

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Authors
  1. J. Graf
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  2. O. Eichelbroenner
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  3. W. J. Sibbald
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Editor information

Editors and Affiliations

  1. Department of Intensive Care, Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Clinical Director) (Clinical Director)

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© 1999 Springer-Verlag Berlin Heidelberg

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Graf, J., Eichelbroenner, O., Sibbald, W.J. (1999). The Red Blood Cell and Nitric Oxide. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 1999. Yearbook of Intensive Care and Emergency Medicine, vol 1999. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-13453-5_39

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  • DOI: https://doi.org/10.1007/978-3-662-13453-5_39

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65288-5

  • Online ISBN: 978-3-662-13453-5

  • eBook Packages: Springer Book Archive

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