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The Glycoprotein MUC1 and Extracellular Matrix Molecules as Markers of Endometrial Differentiation

  • Conference paper
The Endometrium as a Target for Contraception

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 18))

  • 59 Accesses

Abstract

Remarkable alterations occur in the ultrastructure of epithelial cells in the human endometrium during the period from ovulation to implantation (Warren et al. 1994). This applies to both glandular and luminal cell compartments, but the changes are more pronounced in the former. At the time of ovulation the cytoplasm contains free and bound ribosomes, mitochondria and golgi apparatus. The distribution of organelles is not obviously polarised. Proliferation is evident in the epithelial population. By 3 days after the luteinising hormone peak (day LH+3) the fraction of proliferating cells has dropped sharply, and very significant differentiative changes are already apparent, though their extent is at this stage somewhat variable within the cell population. Morphological changes include the appearance of glycogen deposits in the basal cytoplasm, of giant mitochondria enveloped in rough or semi-rough endoplasmic reticulum and of increasingly abundant golgi apparatus in the apical cytoplasm. Stacks of golgi cisternae are visible lying parallel to the apical cell surface; these then expand and reorient parallel to the lateral cell border. By day LH+6 they have become dilated. The apical cytoplasm is now rich in secretory vesicles. Both cilated and microvillous cells are present, and both show secretory capacity (Campbell et al. 1988).

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Authors
  1. J. D. Aplin
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H. M. Beier M. J. K. Harper K. Chwalisz

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© 1997 Springer-Verlag Berlin Heidelberg

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Aplin, J.D. (1997). The Glycoprotein MUC1 and Extracellular Matrix Molecules as Markers of Endometrial Differentiation. In: Beier, H.M., Harper, M.J.K., Chwalisz, K. (eds) The Endometrium as a Target for Contraception. Ernst Schering Research Foundation Workshop, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-10323-4_8

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  • DOI: https://doi.org/10.1007/978-3-662-10323-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-10325-8

  • Online ISBN: 978-3-662-10323-4

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