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Cardiovascular System

  • Chapter
Rational Phytotherapy

Abstract

Phytomedicines play a significant role in the treatment of mild forms of heart failure and coronary insufficiency, in the prevention and treatment of atherosclerosis and its sequelae, and in the symptomatic treatment of chronic venous insufficiency. There are only a few herbal preparations, however, for which safety and efficacy have been adequately proven: hawthorn leaf and flower extract (heart failure and coronary insufficiency), garlic (atherosclerosis), ginkgo extract (peripheral arterial occlusive disease), and horse chestnut extract (chronic venous insufficiency). Therefore, the bulk of this chapter is devoted to these four herbs and their preparations. The closing sections deal briefly with other preparations, including herbs that contain cardioactive digitaloids and herbal remedies for angina pectoris, cardiac arrhythmias, and hypertension and hypotension.

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References

  • Al Makdessi S, Sweidan H, Dietz K, Jacob R (1999) Protective effect of Crataegus oxyacantha against reperfusion arrhythmias after global no-flow ischemia in the rat heart. Basic Res Cardiol 94: 71–6.

    Article  PubMed  Google Scholar 

  • Al Makdessi S, Sweidan H, Milliner S, Jacob R (1996) Myocardial protection by pretreatment with Crataegus oxyacantha. Arzneim Forsch/Drug Res 46 (I): 25–27.

    Google Scholar 

  • American Herbal Pharmacopoeia (1999) Hawthorn leaf with flower. American Herbal Pharmacopoeia, Santa Cruz, USA.

    Google Scholar 

  • Ammon HPT, Händel M (1981) Crataegus, Toxikologie und Pharmakologie. Teil 1: Toxizität. Planta Med 43: 105–120.

    Google Scholar 

  • Anonymus (1984) Camphora (Campher) Bundesanzeiger 228 vom 5. 12. 1984.

    Google Scholar 

  • Beck E, Grünwald J (1993) Allium sativum in der Stufentherapie der Hyperlipidämie. Med Welt 44: 516–520.

    Google Scholar 

  • Belz GG, Butzer R, Gaus W, Loew D (2002) Camphor-Crataegus berry extract combination dose-dependently reduces tilt induced fall in blood pressure in orthostatic hypotension. Phytomedicine 9: 581–8.

    Article  CAS  PubMed  Google Scholar 

  • Belz GG, Loew D (2003) Dose-response related efficacy in orthostatic hypotension of a fixed combination of D-camphor and fresh Crataegus berries and the contribution of the single components. Phytomedicine 10 Suppl IV: 61–67.

    Google Scholar 

  • Belz GG, Loew D (2003) Dose-response related efficacy in orthostatic hypotension of a fixed combination of D-camphor and a fresh Crataegus Berries and the contribution of the single components. Phytomedicine 10 Suppl IV: 61–67.

    Google Scholar 

  • Blumenthal M, Busse WR, Goldberg A et al. (1998) The Complete German Commission E Monographs - Therapeutic Guide to Herbal Medicines. American Botanical Council, Austin, Texas, 1998.

    Google Scholar 

  • Chatterjee SS, Koch E, Jaggy H, Krzeminski T (1997) In-vitro-und In-vivo-Untersuchungen zur kardioprotektiven Wirkung von oligomeren Procyanidinen in einem Crataegus-Extrakt aus Blättern und Blüten. Arzneim Forsch/Drug Res 47 (I): 821–825.

    CAS  Google Scholar 

  • Blumenthal M, Hall T, Goldberg A et al. (2003) The ABC Clinical Guide to Herbs. Austin, TX: American Botanical Council.

    Google Scholar 

  • Bödigheimer K, Chase D (1994) Wirksamkeit von Weißdorn-Extrakt in der Dosierung 3mal 100 mg täglich. Minch Med Wochenschr 136, Suppl. 1: 7–11.

    Google Scholar 

  • Chatterjee SS, Koch E, Jaggy H, Krzeminski T (1997) In-vitro-und In-vivo-Untersuchungen zur kardioprotektiven Wirkung von oligomeren Procyanidinen in einem Crataegus-Extrakt aus Blättern und Blüten. Arzneim Forsch/Drug Res 47 (I): 821–825.

    CAS  Google Scholar 

  • Eichelbaum M (1986) Pharmakogenetische Aspekte der Arzneimitteltherapie. In: Dölle W, MüllerOerlinghausen B, Schwabe U (eds) Grundlagen der Arzneimitteltherapie. Wissenschaftsverlag BI, Mannheim Vienna Zurich, pp. 43 8–448.

    Google Scholar 

  • Eichstädt H, Bäder M, Danne O, Kaiser W, Stein U, Felix R (1989) Crataegus-Extrakt hilft dem Patienten mit NYHA II-Herzinsuffizienz. Therapiewoche 39: 3288–3296.

    Google Scholar 

  • Eichstädt H, Störk T, Möckel M, Danne O, Funk P, Köhler S (2001) Wirksamkeit und Verträglichkeit von Crataegus-Extrakt WS® 1442 bei herzinsuffizienten Patienten mit eingeschränkter linksventrikulärer Funktion. Perfusion 14: 212–217.

    Google Scholar 

  • ESCOP (1999) Crataegi folium cum flore. Monographs on the medicinal uses of plant drugs, Fascicule 6, Exeter, UK.

    Google Scholar 

  • Fischer K, Jung F, Koscielny J, Kiesewetter H (1994) Crataegus-Extrakt vs. Methyldigoxin. Einfluß auf Rheologie und Mikrozirkulation bei 12 gesunden Probanden. Münch Med Wschr 136 (Suppl 1): 35–38.

    Google Scholar 

  • Förster A, Förster K, Bühring M, Wolfstädter HD (1994) Crataegus bei mäßig reduzierter linksven-trikulärer Auswurffraktion. Ergospirometrische Verlaufsuntersuchung bei 72 Patienten in doppelblindem Vergleich mit Plazebo. Munch Med Wschr 136 (Suppl 1): 21–26.

    Google Scholar 

  • Franz G, Hempel B (2000) Natürlicher D-Campher. Deutsche Apotheker Zeitung 140: 1050–56.

    Google Scholar 

  • Hansel R, Keller K, Rimpler H, Schneider G (Hrsg) (1992) Hagers Handbuch der Pharmazeuti- schen Praxis. Vol. 4, Drogen A-D. 5th Ed. Springer Verlag, Berlin Heidelberg: 1040–1056.

    Google Scholar 

  • Hempel B (2000) Toxikologie von D-Campher. In: Rietbrock N (ed) Phytopharmaka VI–Foerschung und Praxis. Steinkopff, Darmstadt, pp. 29–37.

    Chapter  Google Scholar 

  • Holubarsch CJF, Colucci WS, Meinertz T, et al. (2000) Survival and prognosis: investigation of crattaegus extract WS 1442 in congestive heart failure (SPICE) — rationale, study design and study protocol. Eur J Heart Failure 2: 431–7.

    Google Scholar 

  • Jacob R, Ehrsam M, Ohkubo T, Rupp H (1991) Antihypertensive und kardioprotektive Effekte von Knoblauchpulver (Allium sativum). Med Welt (Suppl 7 a): 39–41.

    Google Scholar 

  • Joseph G, Zhao Y, Klaus W (1995) Pharmakologisches Wirkprofil von Crataegus-Extrakt im Vergleich zu Epinephrin, Amrinon, Milrinon und Digoxin am isoliert perfundierten Meerschweinchen-herzen. Arzneim Forsch/Drug Res 45: 1261–1265.

    Google Scholar 

  • Kaul R (ed) (1998) Der Weißdorn. Wissenschaftliche Verlagsges. MbH, Stuttgart.

    Google Scholar 

  • Koch E, Chatterjee SS (2000) Crataegus extract WS-1442 enhances coronary flow in the isolated rat heart by endothelial release of nitric oxide. Naunyn-Schmiedeberg’s Arch Pharmacol 361 Suppl., R48, Abstr. 180.

    Google Scholar 

  • Kreimeyer J (1997) Beiträge zur Analytik von Flavon-3-olen und oligomeren Proanthocyanidinen sowie Untersuchungen zur Pharmakologie von Wirkstoff-Fraktionen und einzelnen Procyanidinen aus einem Weißdorn-Trockenextrakt. Inaugural Dissertation, Universität Münster.

    Google Scholar 

  • Krzeminski T, Chatterjee SS (1993) Ischemia and early reperfusion induced arrhythmias: beneficial effects of an extract of Crataegus oxyacantha L. Pharm Pharmacol Lett 3: 45–48.

    Google Scholar 

  • Kurcok A (1992) lschemia-and reperfusion-induced cardiac inury; effects of two flavonoids containing plant extracts possessing radical scavenging properties. Naunyn-Schmiedebergs’s Arch Pharmacol 345 (Suppl RB 81) Abstr 322.

    Google Scholar 

  • Leuchtgens H (1993) Crataegus-Spezialextrakt WS 1442 bei Herzinsuffizienz NYHA II. Fortschr Med 111: 352–354.

    CAS  PubMed  Google Scholar 

  • Loew D (1994) Crataegus-Spezialextrakte bei Herzinsuffizienz. Kassenarzt 15: 43–52.

    Google Scholar 

  • Loew D (1997) Phytotherapy in heart failure. Phytomedicine 4: 267–271.

    Article  CAS  PubMed  Google Scholar 

  • Müller A, Linke W, Zhao Y, Klaus W (1996) Crataegus extract prolongs action potential duration in guinea-pig papillary muscle. Phytomedicine 3: 257–261.

    Article  PubMed  Google Scholar 

  • Pöpping S, Rose H, Ionescu I, Fischer Y, Kammermeier H (1995) Effect of a hawthorn extract on contraction and energy turnover of isolated rat cardiomyocytes. Arzneim Forsch/ Drug Res 45: 1157–1161.

    Google Scholar 

  • Rotfuß MA, Pascht U, Kissling G (2001) Effect of long-term application of Crataegus oxyacanta on ischemia and reperfusion induced arrhythmias in rats. Arzneim-Forsch/Drug Res 51: 24–28.

    Google Scholar 

  • Rothfuss MA, Pascht U, Kissling G (2001) Effect of long-term application of Crataegus oxyacanta on ischemia and reperfusion induced arrhythmias in rats. Arzneim-Forsch/Drug Res 51: 24–28.

    CAS  Google Scholar 

  • Schlegelmilch R, Heywood R (1994) Toxicity of crataegus (hawthorn) extract (WS 1442). J Am Coll Toxicol 13: 103–111.

    Article  Google Scholar 

  • Schmidt U, Albrecht M, Podzuweit H, Ploch M, Maisenbacher J (1998) Hochdosierte Crataegus- Therapie bei herzinsuffizienten Patienten NYHA-Stadium I und II. Z Phythother 19: 22–30.

    Google Scholar 

  • Schmidt U, Kuhn U, Ploch M, Hübner WD (1994) Wirksamkeit des Extraktes LI 132 (60o mg/Tag) bei 8wöchiger Therapie. Plazebokontrollierte Doppelblindstudie mit Weißdorn an 78 herzinsuffizienten Patienten im Stadium II nach NYHA. Münch Med Wschr 136 (Suppl 1): 13–2o.

    Google Scholar 

  • Schwinger RHG; Pietsch M, Frank K, et al. (2000) Crataegus special extract WS 1442 increases force of contraction in human myocardium cAMP-independently. J Cardiovasc Pharmacol 35: 700–7.

    Article  CAS  PubMed  Google Scholar 

  • Siegel G, Casper U (1996) Crataegi folium cum flore. In: Loew D, Rietbrock N (eds) Phytopharmaka in Forschung und klinischer Anwendung. Steinkopff Verlag, Darmstadt: 1–14.

    Google Scholar 

  • Siegel G, Casper U, Schnalke F (1996) Molecular physiological effector mechanisms of hawthorn extract in cardiac papillary muscle and coronary vascular smooth muscle. Phytotherapie Res 1o: S195–5198.

    Google Scholar 

  • Siegel G, Casper U, Walter H, Hetzer R (1994) Weißdorn-Extrakt LI 132. Dosis-Wirkungs-Studie zum Membranpotential und Tonus menschlicher Koronararterien und des Hundepapillarmuskels. Munch med Wschr 136 (Suppl 1): 47–56.

    Google Scholar 

  • Silagy C, Neil A (1994) A meta-analysis of the effect of garlic on blood pressure. J Hypertension 12: 463–468.

    Article  CAS  Google Scholar 

  • Sticher O, Rehwald A, Meier B (1994) Kriterien der pharmazeutischen Qualität von CrataegusExtrakten. Münch Med Wschr 136 (Suppl 1): 69–73.

    Google Scholar 

  • Tauchert M (2002) Efficacy and safety of crataegus extract WS 1442 in comparison with placebo in patients with chronic stable New York Heart Association class-III heart failure. Am Heart J 143: 910–5.

    Article  CAS  PubMed  Google Scholar 

  • Tauchert M, Gildor A, Lipinski J 1999 ) Einsatz des hochdosierten Crataegusextraktes WS 1442 in der Therapie der Herzinsuffizienz Stadium NYHA II. Herz 24: 465–474.

    Article  CAS  PubMed  Google Scholar 

  • Tauchert M, Loew D (1995) Crataegi folium cum flore bei Herzinsuffizienz. In: Loew D, Rietbrock N (eds) Phytopharmaka in Forschung und klinischer Anwendung. Steinkopff Verlag, Darmstadt: 137–144.

    Chapter  Google Scholar 

  • Tauchert M, Ploch M, Hübner WD (1994) Wirksamkeit des Weißdorn-Extraktes LI 132 im Vergleich mit Captopril. Multizentrische Doppelblindstudie bei 132 Patienten mit Herzinsuffizienz im Stadium II nach NYHA. Munch Med Wschr 136 (Suppl 1): 27–34.

    Google Scholar 

  • Tauchert M, Siegel G, Schulz V (1994) Weißdorn-Extrakt als pflanzliches Cardiacum (Vorwort).

    Google Scholar 

  • Neubewertung der therapeutischen Wirksamkeit. Münch Med Wschr 136 (Suppl 1): 3–5.

    Google Scholar 

  • The Digitalis Investigation Group (1997) The effect of digoxin on mortality and morbidity in patients with heart failure. N Eng J Med 336 (8): 525–533.

    Article  Google Scholar 

  • Upton R (ed.) (1999) Hawthorn leaf with flower. American Herbal Pharmacopoeia, Santa Cruz, CA, USA.

    Google Scholar 

  • Weikl A, Assmus KD, Neukum-Schmidt A, Schmitz J, Zapfe G, Noh HS, Siegrist J (1996) CrataegusSpezialextrakt WS 1442. Fortschr Med 114 (24): 291–296.

    CAS  PubMed  Google Scholar 

  • Weikl A, Noh HS (1992) Der Einfluß von Crataegus bei globaler Herzinsuffizienz. Herz + Gefäße u: 516–524.

    Google Scholar 

  • Weiss RF (Hrsg) (1991) Lehrbuch der Phytotherapie. 7th Edition, Hippokrates Verlag Stuttgart: 223.

    Google Scholar 

  • Zapfe G (2001) Clinical efficacy of Crataegus extract WS® 1442 in congestive heart failure NYHA class II. Phytomedicine 8: 262–266.

    Article  CAS  Google Scholar 

  • Adler AJ, Holub BJ (1997) Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr 65: 445–450.

    CAS  PubMed  Google Scholar 

  • Auer W, Eiber A, Hertkorn E, Höhfeld E, Köhrle U, Lorenz A, Mader F, Merx W, Otto G, Schmid-Otto B, Taubenheim H (1989) Hypertonie und Hyperlipidämie: In leichte-ren Fällen hilft auch Knoblauch. Multizentrische placebokontrollierte Doppelblind-Studie zur lipid-und blutdrucksenkenden Wirkung eines Knoblauchpräparates. Der Allgemeinarzt 1o: 205–208.

    Google Scholar 

  • Aydin A, Ersöz G, Tekesin O, Akcicek E (2000) Garlic oil and Heliobacter pylori infection. Am J Gastroenterol 95: 563–4.

    CAS  PubMed  Google Scholar 

  • Barrie SA, Wright JV, Pizzorno JE (1987) Effects of garlic oil on platelet aggregation serum lipids and blood pressure in humans. J Orthomolec Med 2: 15–21.

    Google Scholar 

  • Beck E, Grünwald J (1993) Allium sativum in der Stufentherapie der Hyperlipidämie Med Welt 44: 516–520.

    Google Scholar 

  • Berthold HK, Sudhop T, von Bergmann, K (1998) Effect of a garlic oil preparation on serum lipoproteins and cholesterol metabolism. JAMA 279: 1900–1902.

    CAS  Google Scholar 

  • Betz E, Weidler R (1989) Die Wirkung von Knoblauchextrakt auf die Atherogenese bei Kaninchen.

    Google Scholar 

  • In: Betz E (Ed) Die Anwendung aktueller Methoden in der Arteriosklerose-Forschung, 304–311. Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS (eds.). Klein S

    Google Scholar 

  • Rister RS (trans). (1998) The Complete German Commission E Monographs Therapeutic Guide to Herbal Medicines. American Botanical Council, Austin, Texas.

    Google Scholar 

  • Bode-Böger SM, Böger RH, Schröder EP, Frölich JC (1994) Exercise increases systemic nitric oxide production in men. J Cardio Risk 1: 173–178.

    Google Scholar 

  • Bordia AK, Verma SK, Vyas AK, Khabya BL, Rathore AS, Bhu N, Bedi HK (1977) Effect of essential oil of onion and garlic on experimental atherosclerosis in rabbits. Atherosclerosis 26: 379–386.

    Article  CAS  PubMed  Google Scholar 

  • Brändle M, Al Makdessi S, Weber RK, Dietz K, Jacob R (1997) Prolongation of life span in hypertensive rats by dietary interventions. Effect of garlic and linseed oil. Basic Res Cardiol 92: 223–232

    Google Scholar 

  • Breithaupt-Grögler K, Ling M, Boudoulas H, Belz GG (1997) Protective Effect of Chronic Garlic Intake on Elastic Properties of Aorta in the Elderly. Circulation 96 (8): 2649–2655.

    Article  PubMed  Google Scholar 

  • Brosche T (1989) Therapeutische Wirkungen einer Knoblauchzubereitung auf den Lipidstatus geriatrischer Probanden. Medwelt 40: 1233–1237.

    Google Scholar 

  • Brosche T, Platt D (1990) Knoblauch als pflanzlicher Lipidsenker: Neuere Untersuchungen mit einem standardisierten Knoblauchtrockenpulver-Präparat. Fortschr Med 108: 703–706.

    Google Scholar 

  • Brosche T, Siegers CP, Platt D (1991) Auswirkungen einer Knoblauch-Therapie auf die Cholesterin Biosynthese sowie auf Plasma-und Membranlipide. Med Welt (Suppl 7a ): 10–11.

    Google Scholar 

  • Burnham BE (1995) Garlic as a possible risk for postoperative bleeding. Plast Recon Surg. 95: 213.

    CAS  Google Scholar 

  • Cavallito CJ, Bailey JH (1944) Allicin, the antibacterial principle of Allium sativum. I.Isolation, physical properties and antibacterial action. J Am Chem Soc 66: 1950–1954.

    Google Scholar 

  • Chandorkar AG, Jain PK (1973) Analysis of hypotensive action of allium sativum (garlic). Indian J Physiol Pharmacol 17: 132–133.

    Google Scholar 

  • Chang MLW, Johnson MA (1980) Effect of garlic on carbohydrate metabolism and lipid syxnthesis in rats. J Nutr no: 931–936.

    Google Scholar 

  • Ciplea AG, Richter KD (1988) The Protective Effect of Allium sativum and Crataegus on Isoprenaline-induced Tissue Necrosis in Rats. Arzneim-Forsch/Drug Res 38 (II): 1583–1592.

    CAS  Google Scholar 

  • Das I, Khan NS, Sooranna SR (1995) Potent activation of nitric oxide synthase by garlic: a basis for its therapeutic applications. Curr Med Res Opin 13: 257–263.

    Article  CAS  PubMed  Google Scholar 

  • De Santos O, Grünwald J (1993) Effect of garlic powder tablets on blood lipids and blood pressure a six month placebo controlled double blind study. Br J Clin Res 4: 37–44.

    Google Scholar 

  • De Santos OS, Johns RA (1995) Effects of garlic powder and garlic oil preparations on blood lipids, blood pressure and well-being. Br J Clin Res 6: 91–100.

    Google Scholar 

  • El-Sabban, F, Radwan GMH (1997) Influence of garlic compared to aspirin on induced photothrombosis in mouse pial microvessels, in vivo. Thrombosis Research 88: 193–203.

    Article  CAS  PubMed  Google Scholar 

  • Eming SA, Piontek JO, Hunzelmann N, Rasokat H, Scharffetter-Kachanek K (1999) Severe toxic contact dermatitis caused by garlic. Br J Dermatol 141: 391–2.

    Article  CAS  PubMed  Google Scholar 

  • Ernst E (1997) Can Allium vegetable can prevent cancer? Phytomedicine 4: 79–83.

    Article  CAS  PubMed  Google Scholar 

  • Ernst E, Weihmayr T, Matrai A (1986) Knoblauch plus Diät senkt Serumlipide. Ärztliche Praxis 38: 1748–1749.

    Google Scholar 

  • Falleroni AE, Zeiss CR, Levitz D (1981) Occupational asthma secondary to inhalation of garlic dust. J Allergy Clin Immunol 68: 156–160.

    Article  CAS  PubMed  Google Scholar 

  • Ferne M (2004) Garlic and Onion in Classic Jewish Literature. HerbalGram 2004; 61: 44–47.

    Google Scholar 

  • Fujiwara M, Itokawa Y, Uchino H, Inoue K (1972) Anti-hypercholesterolemic effect of a sulfur con- taining amino acid, S-methyl-L-cysteine sulfoxide, isolated from cabbage. Experientia 28: 254–255.

    Google Scholar 

  • Gadkari JV, Joshi VD (1991) Effect of ingestion of raw garlic on serum cholesterol leve, clotting time and fibrinolytic activity in normal subjects. J Postgrad Med 37: 128–131.

    CAS  PubMed  Google Scholar 

  • Gebhardt R (1993) Multiple inhibitory effects of Garlic extracts on cholesterol biosynthesis in hepatocytes. Lipids 28 (6): 613–619.

    Article  CAS  PubMed  Google Scholar 

  • Gebhardt R (1995) Amplification of palmitate-induced inhibition of cholesterol biosynthesis in

    Google Scholar 

  • cultured rat hepatocytes by garlic-derived organosulfur compounds. Phytomedicine 2: 29–34.

    Google Scholar 

  • Gebhardt R Beck H (1996) Differential Inhibitory Effects of Garlic-Derived Organosulfur Com-pounds on Cholesterol Biosynthesis in Primary Rat Hepatocyte Cultures. Lipids 31:1269–1276.

    Google Scholar 

  • Gebhardt R, Beck H, Wagner KG (1994) Inhibition of cholesterol biosynthesis by allicin and ajoenein rat hepatocytes and HepG2 cells. Biochem Biphys Acta 1213: 57–62.

    Article  CAS  Google Scholar 

  • Graham Y, Anderson SY, Lang T (1999) Garlic or Jalapeno pepper for treatment of Heliobacter pylori infection. Am J Gastroenterol 94: 1200–2.

    CAS  PubMed  Google Scholar 

  • Harenberg J, Giese C, Zimmermann R (1988) Effect of dried garlic on blood coagulation, fibrinolysis, platelet aggregation and cholesterol in patients with hyperlipoproteinemia. Atherosclerosis 74: 247–249.

    Article  CAS  PubMed  Google Scholar 

  • Heikal HA, Kamel SI, Awaad KE, Khalil NF (1972) A study on the dehydration of garlic slices. Agri Res Rev 5o: 243–253.

    Google Scholar 

  • Heinle H, Betz E (1994) Effects of Dietary Garlic Supplementation in a Rat Model of Atherosclerosis. Arzneimittelforschung/Drug Res 44 (1): 614–617.

    CAS  Google Scholar 

  • Holzgartner H, Schmidt U, Kuhn U (1992) Wirksamkeit and Verträglichkeit eines Knoblauchpulver-Präparates im Vergleich mit Bezafibrat. Arzneimittelforschung/Drug Res 42: 1473–1477.

    CAS  Google Scholar 

  • Isaacsohn JL, Moser M, Stein EA, Dudley K, Davey JA, Liskow E, Black HR (1998) Garlic powder and plasma lipids and lipoproteins: A multicenter randomized, placebo-controlled trial. Arch Intern Med 158: 1189–1194.

    Google Scholar 

  • Isensee H, Rietz B, Jacob R (1993) Cardioprotective Actions of Garlic (Allium sativum) Arzneim Forsch/Drug Res 43 (1): 94–98.

    CAS  Google Scholar 

  • Itokawa Y, Inoue K, Sasagawa S, Fujiwara M (1973) Effect of S- methylcysteine sulfoxide, S-allylcysteine sulfoxide and related sulfur-containing amino acids on lipid metabolism of experimental hypercholesterolemic rats. J Nutr 103: 88–92.

    Google Scholar 

  • Jacob R, Isensee H, Rietz B, Makdessi S, Sweidan H (1993) Cardioprotection by dietary interventions in animal experiments: Effect of garlic and various dietary oils under the conditions of experimental infarction. Pharm Pharmacol Lett 3: 131–134.

    Google Scholar 

  • Jacob R, Rhrsam M, Ohkubo T, Rupp H (1991) Antihypertensive and kardioprotektive Effekte von Knoblauchpulver ( Allium sativum ). Med Welt (Suppl 7a ): 39–41.

    Google Scholar 

  • Jain AK, Vargas R, Gotzkowsky S, McMahon FG (1993) Can Garlic Reduce levels of Serum Lipids? A Controlled Clinical Study. Am J Med 94: 632–635.

    Article  CAS  PubMed  Google Scholar 

  • Jain RC (1975) Onion and garlic in experimental cholesterol atherosclerosis in rabbits I. Effect on serum lipids and development of atherosclerosis. Atery 1: 115–125.

    Google Scholar 

  • Jain RC (1977) Effect of garlic on serum lipids, coagulability and fibrinolytic activity of blood. Am J Clin Nutr 30: 1380–1381.

    CAS  PubMed  Google Scholar 

  • Kamanna VS, Chandrasekhara N (1984) Hypocholesteremic activity of different fractions of garlic. Indian J Med Res 79: 580–583.

    CAS  PubMed  Google Scholar 

  • Kandziora J (1988a) Blutdruck-and lipidsenkende Wirkung eines Knoblauch-Präparates in Kombination mit einem Diuretikum. Ärztliche Forschung 35 (3): 1–8.

    Google Scholar 

  • Kandziora J (1988b) Antihypertensive Wirksamkeit and Verträglichkeit eines Knoblauch-Präparates. Ärztliche Forschung 35 (1): 1–8.

    Google Scholar 

  • Kiesewetter H, Jung EM, Mrowietz C, Koscielny J, Wenzel E (1993a) Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. Eur J Clin Pharmacol 45: 333–336.

    Article  CAS  PubMed  Google Scholar 

  • Kiesewetter H, Jung F, Jung EM, Blume J, Mrowietz C, Birk A, Koscielny J, Wenzel E (1993b) Effects of garlic coated tablet in peripheral arterial occlusive desease. Clin Invest 71: 383–386.

    Article  CAS  Google Scholar 

  • Kiesewetter H, Jung F, Mrowietz C, Wenzel E (1993c) Wirkung von Knoblauch ( Allium sativum L.), insbesondere rheologische and hämostaseologische Effekte. Hämostaseologie 13: 3–12.

    Google Scholar 

  • Kiesewetter H, Jung F, Pindur G, Jung EM, Mrowietz C, Wenzel E (1991) Effect of garlic on thrombocyte aggregation, microcirculation, and other risk factors. Int J Clin Pharm Ther Toxicol 29: 151–155.

    CAS  Google Scholar 

  • Koch HP, Hahn G, Lawson L, Reuter HD, Siegers CP (1996) Garlic - An Introduction to the Therapeutic Applications of Allium sativum. L. Williams & Wilkins, Baltimore.

    Google Scholar 

  • König FK, Schneider B (1986) Knoblauch bessert Durchblutungsstörungen. Ärztliche Praxis 38: 344–345.

    Google Scholar 

  • Koscielny J, Klüßendorf D, Latza R, Baumann-Baretti B, Mayer B Siegel G, Kiesewetter H (1999)

    Google Scholar 

  • The antiatherosclerotic effect of Allium sativum. Atherosclerosis, 144: 237–249.

    Google Scholar 

  • Kourounakis PN, Rekka EA (1991) Effect on Active Oxygen Species of Alliin and Allium Sativum ( Garlic) Powder. Res Commun Chem Pathol Pharmacol 74: 249–252.

    Google Scholar 

  • Lachmann G, Lorenz D, Radeck W, Steiper M (1994) Untersuchungen zur Pharmakokinetik der mit 35-S markierten Knoblauchinhaltsstoffe Alliin, Allicin and Vinyldithiine. Arzneimittelforschung/Drug Res 44: 734–743.

    Google Scholar 

  • Lash JP, Cardoso LR, Mesler PM, Walczak DA, Pollak R (1998) The effect of garlic on hypercholes terolemia in renal transplant patients. Transplantation Proceedings 30: 189–191.

    Article  CAS  PubMed  Google Scholar 

  • Lau BHS, Lam F, Wang-Cheng R (1987) Effect of an odor-modified garlic preparation on blood lipids. Nutrition Research 7: 139–149.

    Article  CAS  Google Scholar 

  • Lewin G, Popov I (1994) Antioxidant Effects of Aqueous Garlic Extract 2nd Communication: Inhibition of CU2+-initiated oxidation of low density lipoproteins. Arzneimittel-Forschung/ Drug Research 44 (1): 604–607.

    CAS  Google Scholar 

  • Liu L, Yeh YY (2000) Inhibition of cholesterol biosynthesis by organosulfur compounds derived from garlic. Lipids 35: 197–203.

    Article  PubMed  Google Scholar 

  • Mader FH, Auer W, Becker W, Böhm W, Brüchert E, Deutsch S (1990) Hyperlipidämie-Behandlung mit Knoblauch-Dragees. Der Allgemeinarzt 12: 435–440.

    Google Scholar 

  • Malik ZA, Siddiqui S (1981) Hypotensive effect of freeze-dried garlic ( Allium sativum) SAP in dog. JPMA 31: 12–13.

    Google Scholar 

  • Mand JK, Gupta PP, Soni GL, Singh R (1985) Effect of garlic on experimental atherosclerosis in rabbits. Indian Heart J 37: 183–188.

    CAS  PubMed  Google Scholar 

  • Mathew PT, Augusti KT (1973) Studies of the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes: Part I - Hypopglycaemic action & enhancement of serum insulin effect & glycogen synthesis. Indian J Biochem Biophys 1o: 209–212.

    Google Scholar 

  • McCrindle BW, Helden E, Conner WT (1998) Garlic extract therapy in children with hypercholesterolemia. Arch Pediatr Adolesc Med 152: 1089–1094.

    CAS  PubMed  Google Scholar 

  • Nakagawa S, Masamoto K, Sumiyoshi H, Harada H (1984) Acute toxicity test of garlic extract. J Toxicol Sci 9: 57–60.

    Article  CAS  PubMed  Google Scholar 

  • Neil A, Silagy C (1994) Garlic: its cardio-protective properties. Curr Opinion Lipid 5: 6–10.

    Article  CAS  Google Scholar 

  • Neil A, Silagy C, Lancaster T, Hodgeman J, Moore JW, Jones L, Fowler GH (1996) Garlic powder in

    Google Scholar 

  • the treatment of moderate hyperlipidaemia: a controlled trial and meta-analysis. J Roy Coll

    Google Scholar 

  • Physicians London 3o: 329–334.

    Google Scholar 

  • Orekhof AN, Tertov VV (1997) In vitro effect of garlic powder extract on lipid content in normal and atherosclerotic human aortic cells. Lipids 32: 1055–60.

    Article  Google Scholar 

  • Orekhow AN, Pivovarova EM, Tertov VV (1996) Garlic powder tablets reduce atherogenicity of low density lipoprotein. A placebo-controlles double-blind study. Nutr Metab Cardiovasc Dis 6: 21–31.

    Google Scholar 

  • Orekhow AN, Tertov VV, Sobenin IA, Pivovarova EM (1995) Direct Antiatherosclerosis-related Effects of Garlic. Ann Med 27: 63–65.

    Article  Google Scholar 

  • Papageogiou D, Corbet JP, Menezes-Brando F, Pecegueiro M, Benezra C (1983) Allergic: contact dermatitis to garlic (Allium sativum L.) identification of the allergens: the role of mono-, di-and trisulfides present in garlic. Arch Dermatol Res 275: 229–234.

    Google Scholar 

  • Patumray S, Tewit S, Amatyakul S et al. (2000) Coparative effects of garlic and aspirin on diabetic cardiovascular complications. Drug Delivery 7: 91–96.

    Article  Google Scholar 

  • Pedraza-Chaverri J, Tapia E, Medina-Campos ON, de los Angeles Granados M, Franco M (1998) Garlic prevents hypertension induced by chronic inhibition of nitric oxide synthesis. Life Sciences 62: 71–77.

    Google Scholar 

  • Petry JJ (1995) Garlic and postoperative bleeding. Plastic Recon Surg 96: 483–484.

    Article  CAS  Google Scholar 

  • Popov I, Blumstein A, Lewin G (1994) Antioxidant Effects of Aqueous Garlic Extract, 1st

    Google Scholar 

  • Communication: Direct detection using the photochemilumin-escence. Arzneimittel-

    Google Scholar 

  • Forschung/Drug Research 44 (1): 602–604.

    Google Scholar 

  • Qureshi AA, Abiurmeileh N, Din ZZ, Elson CE, Burger WC (1983) Inhibition of cholesterol and fatty acid biosynthesis in liver enzymes and chicken hepatocytes by polar fractions of garlic. Lipids 18: 343–348.

    Article  CAS  PubMed  Google Scholar 

  • Reuter HD (1995) Allium sativum und Allium ursinum: Part 2. Pharmacology and Medicinal Application. Phytomedicine 2: 73–91.

    Article  CAS  PubMed  Google Scholar 

  • Reuter HD (1996) Therapeutic Effects and Applications of Garlic and its Preparations. In: Koch HP, Hahn G, Lawson L, Reuter HD, Siegers CP (Eds) Garlic - An Introduction to the Therapeutic Applications of Allium sativum. L. Williams & Wilkins, Baltimore.

    Google Scholar 

  • Reuter HD, Sendl A (1994) Allium sativum und Allium ursinum: Chemistry, Pharmacology and Medical applications. Econo Med Plant Res 6: 56–108.

    Google Scholar 

  • Rose KD, Croissant PD, Parliament CF, Levin MB (1990) Spontaneous Spinal Epidural Hematoma with Associated Platelet Dysfunction from Excessive Garlic Ingestion: A Case Report. Neurosurgery 26: 880–882.

    Google Scholar 

  • Rotzsch W, Richter V, Rassoul F (1992) Postprandiale Lipämie unter Medikation von Allium sativum. Arzneimittel-Forschung/Drug Res 42 (II): 1223–1227.

    CAS  Google Scholar 

  • Saradeth T, Seidl S, Resch KL, Ernst E (1994) Does garlic alter the lipid pattern in normal volunteers? Phytomedicine 1: 183–185.

    Article  CAS  PubMed  Google Scholar 

  • Schmidt U, Schenk N (1992) Geruchsbildung bei repetierter Einnahme von standardisierten Knoblauchpulver-Dragees Kwai ( LI ni) in Abhängigkeit von der Tagesdosis. Wissenschaftlicher Bericht.

    Google Scholar 

  • Schwartzkopff W, Bimmermann A, Schleicher J (1988) Klinische Studie mit Li u2-Knoblauchdragees. Wissenschaftlicher Bericht.

    Google Scholar 

  • Siegel G, Emden J, Schnalke F, Walter A, Rückborn K, Wagner KG (1991) Wirkungen von Knoblauch auf die Gefäßregulation. Med Welt (Suppl 7a ): 32–34.

    Google Scholar 

  • Siegel G, Emden J, Wenzel K, Mironneau J, Stock G (1992) Potassium channel activation in vascular smooth muscle. In: Frank GB (Ed) Excitation-Contraction Coupling in Skeletal, Cardiac and Smooth Muscle, Plenum Press, New York: 53–72.

    Chapter  Google Scholar 

  • Siegel G, Klüßendorf D (2000) The anti-atherosclerotic effect of Allium sativum: Statistics reevaluated. Atherosclerosis 150: 437–8.

    Google Scholar 

  • Siegel G, Malmsten M, Schneider W, Michel F (2004) The effect of garlic on arteriosclerotic nanoplaque formation and size. Phytomedicine n, in press

    Google Scholar 

  • Siegel G, Nuck R, Schnalke F, Michel F (1998) Molecular evidence for phytopharmacological K+ channel opening by garlic in human vascular smooth muscle cell membranes. Phytotherapy Research 12: 149–151.

    Article  Google Scholar 

  • Siegel G, Walter A, Engel S, Walper A, Michel F (1999) Pleiotrope Wirkungen von Knoblauch. Wiener Med Wschr 149. 217–224.

    CAS  Google Scholar 

  • Siegers P, Röbke A, Pentz R (1999) Effects of garlic preparations on superoxide production by phorbol ester activated granulocytes. Phytomedicine 6: 13–16.

    Article  CAS  PubMed  Google Scholar 

  • Silagy C, Neil A (1994) A meta-analysis of the effect of garlic on blood pressure. J Hypertension 12: 463–468.

    Article  CAS  Google Scholar 

  • Silagy C, Neil A (1994) Garlic as a lipid lowering agent–a meta-analysis. J R Coll Physicians 28 (1): 2–8.

    Google Scholar 

  • Simons LA, Balasubramaniam S, von Konigsmark M, Parfitt A, Simons J, Peters W (1995) On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. Atherosclerosis 113: 219–225.

    Article  CAS  PubMed  Google Scholar 

  • Sivam GP (2001) Protection against Heliobacter pylori and other bacterial infections by garlic. J Nutr 131: iio6S-uo8S.

    Google Scholar 

  • Stevinson C, Pittler MH, Ernst E (2000) Garlic for treating hypercholesterolemia. Ann Intern Med 133: 420–9.

    CAS  PubMed  Google Scholar 

  • Sunter WH (1991) Warfarin and garlic. Pharm J 246: 722.

    Google Scholar 

  • Superko R, Krauss RM (moo) Garlic powder, effect on plasma lipids, postprandial lipemia, low-density lipoprotein particle size, high-density lipoprotein subclass distribution and lipoprotein(a). JACC 35: 321–6.

    Google Scholar 

  • Török B, Belägyi J, Rietz B, Jakob R (1994) Effectiveness of Garlic on the Radical Activity in Radical Generating Systems. Arzneimittelforschung/Drug Research 44 (I): 608–611.

    Google Scholar 

  • Vorberg G, Schneider B (1990) Therapie mit Knoblauch: Ergebnisse einer placebokontrollierten Doppelblindstudie. Natur-und Ganzheitsmedizin 3: 2–6.

    Google Scholar 

  • Walper A, Rassoul F, Purschwitz K, Schulz V (1994) Effizienz einer Diätempfehlung und einer zusätzlichen Phytotherapie mit Allium sativum bei leichter bis mäßiger Hypercholesterinämie. Medwelt 45: 327–332.

    Google Scholar 

  • Warshafsky S, Kamer RS, Sivak L (1993) Effect of garlic on total serum cholesterol. Ann Inter Med 119: 599–605.

    CAS  Google Scholar 

  • Zacharias NT, Sebastian KL, Philip B, Augusti KT (1980) Hypoglycemic and Hypolipidaemic Effects of Garlic in Sucrose fed Rabbits. Ind J Physiol Pharmac 24: 151–154.

    CAS  Google Scholar 

  • Zhao F, Chen H, Shen Y, Liu Z, Chen Y, Sun X, Cheng G, Lang L (1983) Study of synthetic allicin on the prevention and treatment of atherosclerosis. Chem Abst 98: 209. 844.

    Google Scholar 

  • Zimmermann W, Zimmermann B (199o) Senkung erhöhter Blutfette durch ein Knoblauch-Präparat: Offene Studie an stationären Patienten. Der Bayerische Internist 1o: 40–43

    Google Scholar 

  • Baghurst KI, Raj MI, Truswell AS (1977) Onions and platelet aggregation. Lancet loi: 1051.

    Google Scholar 

  • Bauer U (1984) Six-month double-blind randomised clinical trial of Ginkgo biloba extract versus placebo in two parallel groups in patients suffering from peripheral arterial insufficiency. Arzneim-Forsch/Drug Res 34: 716–720.

    CAS  Google Scholar 

  • Blume J, Kieser M, Hölscher U (1996) Placebokontrollierte Doppelblindstudie zur Wirksamkeit von Ginkgo-biloba-Spezialextrakt EGb 761 bei austrainierten Patienten mit Claudicatio inter-mittens. VASA 25: 265–274.

    CAS  Google Scholar 

  • Blume J, Kieser M, Hölscher U (1998) Randomisierte placebokontrollierte Doppelblindstudie zum Nachweis der klinischen Wirksamkeit von EGb 761 bei Patienten mit peripherer arterieller Verschlußkrankheit im Stadium IIb nach Fontaine. Fortschritte der Medizin 116: 137–43.

    Google Scholar 

  • Blumenthal M, Busse WR, Goldberg A, Gruenwald J, Hall T, Riggins CW, Rister RS (eds.). Klein S, Rister RS (trans). (1998) The Complete German Commission E Monographs - Therapeutic Guide to Herbal Medicines.

    Google Scholar 

  • American Botanical Council, Austin, Bulling G, von Bary S (1991) Behandlung der chronischen peripheren arteriellen Verschlußkrankheit mit physikalischem Training und Ginkgo-biloba-Extrakt 761. Med Welt 42: 702–708.

    Google Scholar 

  • Fischer S, Berg A, Keul J, Leitzmann C (1991) Einfluß einer ballaststoffangereicherten Kost auf die Ernährungsgewohnheiten und die Blutfettwerte bei Hypercholesterinämikern. Aktuelle Ernährungsmedizin 16. 303–309.

    Google Scholar 

  • Geleijnse JM, Launer LJ, Hoffmann A et al. (1999) Tea flavanoids may protect against atherosclerosis. The Rotterdam Study. Arch Intern Med 159: 2170–4.

    Google Scholar 

  • Gold KK, Davidson DM (1988) Oat bran as a cholesterol-reducing dietary adjunct in an young healthy population. West J Med 148: 299–302.

    CAS  PubMed  Google Scholar 

  • Heber D, Yip I, Ashley JM, Elashoff DA, Elashoff RM, Go VLW (1999) Cholesterol-lowering effects of a proprietary Chinese red-yeast-rice dietary supplement. Am J Clin Nutr 69: 231–236.

    CAS  PubMed  Google Scholar 

  • Letzel H, Schoop E (1992) Ginkgo-biloba-Extrakt EGb 761 und Pentoxifyllin bei Claudicatio intermittens. VASA 21: 403–410.

    CAS  Google Scholar 

  • Menon IS, Kendal RY, Dewar HA, Newell DJ (1968) Effects of onion on blood fibrinolytic activity. Brit Med J 3: 351.

    Article  CAS  PubMed  Google Scholar 

  • Moher D, Pham B, Ausejo M, et al. (2000) Pharmacological management of intermittent claudication. A meta-analysis of randomised trials. Drugs 59: 1557–70.

    Google Scholar 

  • Peters H, Kieser M, Hölscher U (1998) Demonstration of the efficacy of ginkgo biloba special extract EGb 761on intermittent claudication - a placebo-controlled, double-blind multicenter trial. VASA 27: 106–110.o.

    Google Scholar 

  • Pittler MH, Ernst E (2000) Ginkgo biloba extract for the treatment of intermittent claudication. A metaanalysis of randomised trials. Am J Med 108: 276–81.

    Google Scholar 

  • Schneider B (1992) Ginkgo-biloba-Extrakt bei peripheren arteriellen Verschlußkrankheiten. Arzneim Forsch/Drug Res 42: 428–436.

    CAS  Google Scholar 

  • Schoop W (1997) Klinische Prüfung mit Ginkgo-biloba-Spezialextrakt EGb 761 bei Patienten mit peripherer arterieller Verschlußkrankheit im Stadium IIb nach Fontaine im Vergleich zu Placebo. VASA 26: 160.

    Google Scholar 

  • Shen Z, Yu P, Su M, Chi J, Zhou Y, Zhu X, Yang C, He C (1996) A prospective study on Zhitai capsule in the treatment of primary hyperlipidemia. Nat Med J China 76: 156–157.

    Google Scholar 

  • Skinner W (1988) Cholestin declared dietary supplement and FDA enjoined. Nat Med Law 2(1): 1, 6.

    Google Scholar 

  • Wang J, Su M, Lu Z, Kou W, Chi J, Yu P, Wang W (1995) Clinical trial of extract of Monascus purpureus (red yeast) in the treatment of hyperlipidemia. Clin J Exp Ther Prep Chin Med 12: 1–5.

    Google Scholar 

  • Alter H (1973) Zur medikamentösen Therapie der Varikosis. Z Allg Med 49 (17): 1301–1304. Annoni F, Mauri A, Marincola 17, Resele LF (1959) Venotonic activity of aescin on the human saphenous vein. Arzneim Forsch/Drug Res 29: 672.

    Google Scholar 

  • Bisler H, Pfeifer R, Klüken N, Pauschinger P (1986) Wirkung von Roßkastaniensamenextrakt auf die transkapilläre Filtration bei chronischer venöser Insuffizienz. Dtsch Med Wschr n1: 1321–1328.

    Article  Google Scholar 

  • Diehm C, Trampisch HJ, Lange S, Schmidt C (1996) Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet 347: 292–294.

    Article  CAS  PubMed  Google Scholar 

  • Fink Serralde C, Dreyfus Cortes GO, Colo Hernandez, Marquez Zacarias LA (1975) Valoracion de la escina pura en el tratamiento del sindrome des estasis venosa cronica. Munch Med Wschr (Spanish edition) 117 (1): 41–46.

    Google Scholar 

  • Fricke U (1995) Venenmittel. In: Schwabe U, Paffrath D (eds) Arzneiverordnungs-Report ‘85. Gustav Fischer Verlag, Stuttgart Jena, pp 421–430.

    Google Scholar 

  • Friedrich HC, Vogelsberg H, Neiss A (1978) Ein Beitrag zur Bewertung von intern wirksamen Venenpharmaka. Z Hautkrankheiten 53 (u): 369–374.

    Google Scholar 

  • Hansel R, Keller K, Rimpler H, Schneider G (1992) Hagers Handbuch der Pharmazeutischen

    Google Scholar 

  • Praxis. 5th Ed., Drogen A-D.Springer Verlag, Berlin Heidelberg New York, pp 108–122.

    Google Scholar 

  • Hitzenberger G (1989) Die therapeutische Wirksamkeit des Roßkastaniensamenextraktes. Wien Med Wschr 139 (17): 385–389.

    CAS  PubMed  Google Scholar 

  • Locks H, Baumgartner H, Konzett H (1974) Zur Beeinflussung des Venentonus durch Roßkastanienextrakte. Arzneim Forsch 24: 1347.

    Google Scholar 

  • Lohr E, Garanin G, Jesau P, Fischer H (1986) Ödemprotektive Therapie bei chronischer Veneninsuffizienz mit Ödemneigung. Minch Med Wschr 128: 579–581.

    Google Scholar 

  • Longiave D, Omini C, Nicosia S, Berti F (1978) The mode of action of aescin on isolated veins: relationship with PGF2a. Pharmacol Res 1o: 145.

    Google Scholar 

  • Lorenz D, Marek ML (1960) Das therapeutisch wirksame Prinzip der Roßkastanie ( Aesculus hippocastanum ). Arzneim Forsch 1o: 263–272.

    Google Scholar 

  • Marshall M, Loew D (1994). Diagnostische Maßnahmen zum Nachweis der Wirksamkeit von Venentherapeutika. Phlebol 23: 85–91.

    Google Scholar 

  • Marshall M, Dormandy JA (1987) Oedema of long distant flights. Phlebol 2: 123–124.

    Google Scholar 

  • Neiss A, Böhm C (1976) Zum Wirksamkeitsnachweis von Roßkastaniensamenextrakt beim varikösen Symptomenkomplex. Munch Med Wschr 7: 213–216.

    Google Scholar 

  • Pauschinger P (1987) Klinisch experimentelle Untersuchungen zur Wirkung von Roßkastaniensa-menextrakt auf die transkapilläre Filtration und das intravasale Volumen an Patienten mit chronisch venöser Insuffizienz. Phlebol Proktol 16: 57–61.

    Google Scholar 

  • Pittler MH, Ernst E (1998) Horse-chestnut seed extract for chronic venous insufficiency. A criteria-based systematic review. Arch Dermatol 134: 1356–1360.

    Google Scholar 

  • Rudofsky G, Neiß A, Otto K, Seibel K (1986) Ödemprotektive Wirkung und klinische Wirksamkeitvon Roßkastaniensamenextrakt im Doppelblindversuch. Phlebol Proktol 15: 47–54.

    Google Scholar 

  • Steiner M, Hillemanns HG (1986) Untersuchung zur ödemprotektiven Wirkung eines Venenthe-rapeutikums. Munch Med Wschr 31: 551–552.

    Google Scholar 

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Schulz, V., Hänsel, R., Blumenthal, M., Tyler, V.E. (2004). Cardiovascular System. In: Rational Phytotherapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09666-6_3

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