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Parasite Antigens in Protection, Diagnosis and Escape pp 43–67Cite as

Parasite Antigens, Their Role in Protection, Diagnosis and Escape: The Leishmaniases

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 120))

Abstract

The leishmaniases comprise a group of diseases of major and increasing public health importance (WHO Technical Report 701, 1984). The genus consists of many species which are epidemiologically diverse and complex. Nevertheless, all leishmanias are transmitted by sandfly vectors, either of the genus Phlebotomus (Old World) or Lutzomyia (New World), and they are all obligate intracellular parasites in their vertebrate hosts where they are found within macrophage phagolysomes (Alexander and Vickerman 1975; Chang and Dwyer 1976). Although the forms found infecting macrophages, amastigotes, are for the most part morphologically identical, the diseases produced in man display widely different clinical manifestations. This depends primarily on the species of parasite initiating the infection, but also in part on the general state of health or age, and more particularly, the genetic make-up of the host (Blackwell and Alexander 1985). The major disease-causing species of Leishmania in man are summarised in Table 1.

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Authors and Affiliations

  1. Department of Bioscience and Biotechnology, The Todd Centre, University of Strathclyde, Glasgow, G4 0NR, Scotland, UK

    J. Alexander

  2. Max-Planck-Institut für Biologie, Corrensstraße 38, D-7400, Tübingen, Germany

    D. G. Russell

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  1. J. Alexander
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  2. D. G. Russell
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  1. National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK

    R. M. E. Parkhouse MD

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© 1985 Springer-Verlag Berlin Heidelberg

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Alexander, J., Russell, D.G. (1985). Parasite Antigens, Their Role in Protection, Diagnosis and Escape: The Leishmaniases. In: Parkhouse, R.M.E. (eds) Parasite Antigens in Protection, Diagnosis and Escape. Current Topics in Microbiology and Immunology, vol 120. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-09197-5_4

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  • DOI: https://doi.org/10.1007/978-3-662-09197-5_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-09199-9

  • Online ISBN: 978-3-662-09197-5

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