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Induktion und Inhibition des Metabolismus organischer Nitrate

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Nitrate III

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Zusammenfassung

Gefäßerweiternde organische Nitrate, wie Glyceryl-Trinitrat (GTN) oder Isosorbiddinitrat (ISDN) werden durch Glutathion-(GSH-) S-Transferasen (EC 2.5.1.18) nach dem allgemeinen Schema

denitriert.

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Literatur

  1. Chasseaud LF, Down WH, Sacharin RM (1978) Effect of repeated oral administration of isosorbide dinitrate on hepatic glutathione S-transferase activity in the rat. Biochem Pharmacol 27:1695

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  2. Down WH, Chasseaud LF (1979) Effect of repeated oral administration of phenobarbitone or DDT on hepatic glutathione S-transferase activity in non-human primates: comparison with the rat. Biochem Pharmacol 28:3525

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  3. Jakoby WB, Habig WH, Ketley JN, Pabst MJ (1976) Glutathione S-transferases: Catalytic aspects. In: Arias IM, Jakoby WB (eds) Glutathione: Metabolism and function. Raven Press, New York, p 189

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  4. Kosower EM, Kosower NS (1976) Chemical basis of the perturbation of glutathione-glutathione disulphide status of biological systems by diazenes. In: Arias IM, Jakoby WB (eds) Glutathione: Metabolism and function. Raven Press, New York, p 139

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  5. Needleman P, Johnson EM (1975) The pharmacological and biochemical interaction of organic nitrates with sulfhydryls: possible correlations with the mechanism for tolerance development, vasodilation and mitochondrial and enzyme reactions. In: Needleman P (ed) Organic nitrates. Springer, Berlin Heidelberg New York, p 97

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  6. Thadani U, Manyari D, Parker JO, Fung HL (1980) Tolerance to the circulatory effects of oral isosorbide dinitrate. Circulation 61:526

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Authors
  1. W. H. Down
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  2. L. F. Chasseaud
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  3. S. A. Ballard
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Editor information

Editors and Affiliations

  1. Zentralkrankenhaus „Links der Weser“, Senator-Weßling-Straße, D-2800, Bremen 61, Deutschland

    Heinz Jürgen Engel

  2. Pharma-Schwarz GmbH, D-4019, Monheim, Deutschland

    Alfred Schrey

  3. Abteilung für Kardiologie, Med. Hochschule Hannover, Karl-Wiechert-Allee 9, D-3000, Hannover 61, Deutschland

    Paul Robert Lichtlen

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© 1982 Springer-Verlag Berlin Heidelberg

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Down, W.H., Chasseaud, L.F., Ballard, S.A. (1982). Induktion und Inhibition des Metabolismus organischer Nitrate. In: Engel, H.J., Schrey, A., Lichtlen, P.R. (eds) Nitrate III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-08981-1_15

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  • DOI: https://doi.org/10.1007/978-3-662-08981-1_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-11509-0

  • Online ISBN: 978-3-662-08981-1

  • eBook Packages: Springer Book Archive

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