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Estrogens: From Classical Endocrine Action to Tissue Selective Action

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New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 46))

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Abstract

Beginning in the late 1950s into the 1970s the laboratories of El-wood Jensen and Jack Gorski proposed a model by which the inter-action of the receptor and 17ß-estradiol (E2) are involved in transducing the cellular effects of this hormone (Jensen and DeSombre 1973; Toft and Gorski 1966). Their laboratories also performed the isolation and initial characterization of the estrogen receptor (ER; Jensen and DeSombre 1973; Toft and Gorski 1966). Since its initial discovery, significant progress has been made in understanding the mechanisms and manifestations of ER action; however, many new questions have emerged that make this area of research as exciting and interesting as it was 40 years ago.

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  1. C. R. Lyttle
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  2. B. S. Komm
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  3. B. J. Cheskis
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K. S. Korach A. Hillisch K. H. Fritzemeier

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Lyttle, C.R., Komm, B.S., Cheskis, B.J. (2004). Estrogens: From Classical Endocrine Action to Tissue Selective Action. In: Korach, K.S., Hillisch, A., Fritzemeier, K.H. (eds) New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy. Ernst Schering Research Foundation Workshop, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-05386-7_1

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  • DOI: https://doi.org/10.1007/978-3-662-05386-7_1

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