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Guidelines for the care and use of laboratory animals

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Drug Discovery and Evaluation

Abstract

Blood is collected from laboratory animals for various scientific purposes, for example, to study the effects of a test drug on various constituents, such as hormones, substrates, or blood cells. In the field of pharmacokinetics and drug metabolism, blood samples are necessary for analytical determination of the drug and its metabolites. Blood is also needed for some in vitro assays using blood cells or defined plasma protein fractions.

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References

  • Commission of the European Communities, Recommendations for euthanasia of experimental animals. Final report (1993)

    Google Scholar 

  • First Report of the BVA/FRAME/RSPCA/UFAW Joint Working Group on Refinement, Removal of blood from laboratory mammals and birds. Laboratory Animals (1993) 27: 1 - 22

    Google Scholar 

  • Gainer JL, Lipa MJ Ficenec MC (1995) Hemorrhagic shock in rats. Laboratory Animal Science 45: 169 - 172

    PubMed  CAS  Google Scholar 

  • HC, Beynen AC (1992) Histological changes in the orbital region of rats after orbital puncture. Laboratory Animals 26: 53 - 58

    Google Scholar 

  • McGuill MW, Rowan AN (1989) Biological effects of blood loss: implications for sampling volumes and techniques. ILAR News 31: 5 - 18

    Google Scholar 

  • Tsukamoto H, Reidelberger RD, French SW, Largman C (1984) Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol 247 (Regulatory Integrative Comp Physiol 16): R595 — R599

    PubMed  CAS  Google Scholar 

  • van Herck H, Baumans V, van der Craats NR, Hesp APM, Meijer GW, van Tintelen G, Walvoort HC, Beynen AC (1992) Histological changes in the orbital region of rats after orbital puncture. Laboratory Animals 26: 53 - 58

    Article  PubMed  Google Scholar 

  • Wiersma J, Kastelijn J (1985) A chronic technique for high frequency blood sampling/transfusion in the freely behaving rat which does not affect prolactin and corticosterone secretion. J Endocr 107: 285 - 292

    Article  PubMed  CAS  Google Scholar 

  • Alpert M, Goldstein D, Triner L (1982) Technique of endotracheal intubation in rats. Lab Anim 32: 78 - 79

    CAS  Google Scholar 

  • Erhard W, Scherer M, Greiner C, Blümel G (1985) Methods of low term anaesthesia in the rat. Z Versuchstierkunde 27: 84

    Google Scholar 

  • Guedel AE (1951) Inhalation Anaesthesia. MacMillan, New York

    Google Scholar 

  • Sawyer DC (1983) The Practice of Small Animal Anaesthesia. W.B. Saunders, Philadelphia

    Google Scholar 

  • Van Pelt LF (1977) Ketamine and xylazine for surgical anaesthesia in rats. J Am Vet Med. Assoc 171: 842 - 844

    PubMed  Google Scholar 

  • Commission of the European Communities (1993) Recommendations for euthanasia of experimental animals. Final report

    Google Scholar 

  • Federal Veterinary Office, Switzerland (1993) Guidelines for skillful and human euthanasia of laboratory animals

    Google Scholar 

  • Hellebrekers LS, Baumans V, Bertens APMG, Hartman W (1990) On the use of T61 for euthanasia of domestic and laboratory animals; an ethical evaluation. Laboratory Animals 24: 200 - 204

    Article  PubMed  CAS  Google Scholar 

  • Rowan A (1992) More on decapitation and scientific research. Science and Animal Care, Vol, No. 3: 3

    Google Scholar 

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© 1997 Springer-Verlag Berlin Heidelberg

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Herling, A.W., Maas, J., Seeger, K. (1997). Guidelines for the care and use of laboratory animals. In: Vogel, H.G., Vogel, W.H. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03333-3_14

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  • DOI: https://doi.org/10.1007/978-3-662-03333-3_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-03335-7

  • Online ISBN: 978-3-662-03333-3

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