Abstract
Blood is collected from laboratory animals for various scientific purposes, for example, to study the effects of a test drug on various constituents, such as hormones, substrates, or blood cells. In the field of pharmacokinetics and drug metabolism, blood samples are necessary for analytical determination of the drug and its metabolites. Blood is also needed for some in vitro assays using blood cells or defined plasma protein fractions.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Commission of the European Communities, Recommendations for euthanasia of experimental animals. Final report (1993)
First Report of the BVA/FRAME/RSPCA/UFAW Joint Working Group on Refinement, Removal of blood from laboratory mammals and birds. Laboratory Animals (1993) 27: 1 - 22
Gainer JL, Lipa MJ Ficenec MC (1995) Hemorrhagic shock in rats. Laboratory Animal Science 45: 169 - 172
HC, Beynen AC (1992) Histological changes in the orbital region of rats after orbital puncture. Laboratory Animals 26: 53 - 58
McGuill MW, Rowan AN (1989) Biological effects of blood loss: implications for sampling volumes and techniques. ILAR News 31: 5 - 18
Tsukamoto H, Reidelberger RD, French SW, Largman C (1984) Long-term cannulation model for blood sampling and intragastric infusion in the rat. Am J Physiol 247 (Regulatory Integrative Comp Physiol 16): R595 — R599
van Herck H, Baumans V, van der Craats NR, Hesp APM, Meijer GW, van Tintelen G, Walvoort HC, Beynen AC (1992) Histological changes in the orbital region of rats after orbital puncture. Laboratory Animals 26: 53 - 58
Wiersma J, Kastelijn J (1985) A chronic technique for high frequency blood sampling/transfusion in the freely behaving rat which does not affect prolactin and corticosterone secretion. J Endocr 107: 285 - 292
Alpert M, Goldstein D, Triner L (1982) Technique of endotracheal intubation in rats. Lab Anim 32: 78 - 79
Erhard W, Scherer M, Greiner C, Blümel G (1985) Methods of low term anaesthesia in the rat. Z Versuchstierkunde 27: 84
Guedel AE (1951) Inhalation Anaesthesia. MacMillan, New York
Sawyer DC (1983) The Practice of Small Animal Anaesthesia. W.B. Saunders, Philadelphia
Van Pelt LF (1977) Ketamine and xylazine for surgical anaesthesia in rats. J Am Vet Med. Assoc 171: 842 - 844
Commission of the European Communities (1993) Recommendations for euthanasia of experimental animals. Final report
Federal Veterinary Office, Switzerland (1993) Guidelines for skillful and human euthanasia of laboratory animals
Hellebrekers LS, Baumans V, Bertens APMG, Hartman W (1990) On the use of T61 for euthanasia of domestic and laboratory animals; an ethical evaluation. Laboratory Animals 24: 200 - 204
Rowan A (1992) More on decapitation and scientific research. Science and Animal Care, Vol, No. 3: 3
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1997 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Herling, A.W., Maas, J., Seeger, K. (1997). Guidelines for the care and use of laboratory animals. In: Vogel, H.G., Vogel, W.H. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-03333-3_14
Download citation
DOI: https://doi.org/10.1007/978-3-662-03333-3_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-03335-7
Online ISBN: 978-3-662-03333-3
eBook Packages: Springer Book Archive