Abstract
The spatial organization of cells and organelles is an important feature in the regulation of metabolism. It is the basis for the compartmentalization of enzymes and the channeling of precursors, intermediates, and products to the sites of metabolic activity. At the cellular level it is brought about either by membranes separating cytoplasmic and noncytoplasmic areas or by the influence of micro environmental effects which form “microcompartments” within the cell, e.g., by mutual binding of proteins, location of enzymes near each other in membranes, and by so-called unstirred layer effects. These structural characters give rise to high local concentrations of reactants, the protection of reactive intermediates and the directed transport of precursors, intermediates, and products. They favor certain sequences of reactions (metabolic channeling) and thus facilitate the formation and function of metabolic chains.
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Luckner, M., Diettrich, B., Lerbs, W.: Cellular compartmentation and channelling of secondary metabolism in microorganisms and higher plants. Prog. Phytochem. 6, 103–142 (1980)
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Luckner, M. (1984). Cellular Compartmentalization and Channeling. In: Secondary Metabolism in Microorganisms, Plants and Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-02384-6_3
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DOI: https://doi.org/10.1007/978-3-662-02384-6_3
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