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Platelet Abnormalities in Human Hypertension

  • Conference paper
Cellular Aspects of Hypertension

Abstract

The importance accorded to platelet function in the pathogenesis of hypertension and its complications rests on many considerations. Platelets may be argued to play a patho-physiological role, since they produce vasoconstrictors (e.g., thromboxane, TXA2, and serotonin, 5-HT) and growth factors (platelet-derived growth factor, PDGF), as well as participating actively in the development of thromboembolic complications. On the other hand, vasoconstrictor factors, such as epineprine, angiotensin II, and vasopressin, are capable to activate or sensitize the platelets by acting on specific receptors. In hypertension, increased shear stress on the vessel wall and the resulting endothelial damage can also activate the platelets, with important consequences in the onset and continuation of the atherosclerotic process. Finally, if the hypothesis is accepted that essential hypertension is characterized by a widespread genetically determined cellular abnormality, this could affect not only the smooth muscle cells of the blood vessels, but also other cells such as platelets.

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Authors and Affiliations

  1. Istituto di Clinica Medica, Università di Verona, Via Delle Menegone, I-37134, Verona, Italy

    A. Lechi, E. Arosio & P. Minuz

  2. Istituto di Chimica Clinica, Università di Verona, Via Delle Menegone, I-37134, Verona, Italy

    C. Lechi, C. Lauciello, P. Guzzo & M. Zatti

Authors
  1. A. Lechi
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  2. C. Lechi
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  3. C. Lauciello
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  4. P. Guzzo
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  5. E. Arosio
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  6. P. Minuz
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  7. M. Zatti
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Editors and Affiliations

  1. Istituto di Clinica Medica e Nefrologia, Facolta di Medicina e Chirurgia, Università degli Studi di Parma, Via A. Gramsci, 14, I-43100, Parma, Italy

    Giacomo Bruschi  & Alberico Borghetti  & 

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© 1991 Springer-Verlag Berlin • Heidelberg

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Lechi, A. et al. (1991). Platelet Abnormalities in Human Hypertension. In: Bruschi, G., Borghetti, A. (eds) Cellular Aspects of Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-00983-3_23

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  • DOI: https://doi.org/10.1007/978-3-662-00983-3_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-00985-7

  • Online ISBN: 978-3-662-00983-3

  • eBook Packages: Springer Book Archive

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