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Hypothalamic Lesions Associated with Streptozotocin Diabetes, Rat

  • Chapter
Endocrine System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Changes in neurons, myelinated fibers, and tanycytes are found in hypothalamic sections II–IV (see p. 316) of diabetic animals. Under light microscopy, round vesicles of various size are frequently seen in the basal region of the arcuate nucleus and in the lateral median eminence. Neurons in these nuclei contain variable amounts of glycogen that stain positively with PAS (Fig. 326a, b). Semiquantitatively, the difference between diabetics and controls is highly significant (P<0.01).

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Authors
  1. Gilberto Bestetti
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  2. Giovanni L. Rossi
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Editor information

Editors and Affiliations

  1. New England Regional Primate Research Center, Emeritus Harvard Medical School, One Pine Hill Drive, 01772, Southborough, MA, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

  2. Institut für Experimentelle Pathologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Strasse 8, 3000, Hannover 61, West Germany

    Ulrich Mohr

  3. New England Regional Primate Research Center, Harvard Medical School, 01772, Southborough, MA, USA

    Ronald Duncan Hunt D.V.M. (Professor of Comparative Pathology) (Professor of Comparative Pathology)

  4. Ohio State University, 43210, Columbus, OH, USA

    Charles C. Capen D.V.M., Ph.D. (Professor of Pathobiology and Endocrinology) (Professor of Pathobiology and Endocrinology)

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© 1983 Springer-Verlag Berlin Heidelberg

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Bestetti, G., Rossi, G.L. (1983). Hypothalamic Lesions Associated with Streptozotocin Diabetes, Rat. In: Jones, T.C., Mohr, U., Hunt, R.D., Capen, C.C. (eds) Endocrine System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96720-7_65

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  • DOI: https://doi.org/10.1007/978-3-642-96720-7_65

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96722-1

  • Online ISBN: 978-3-642-96720-7

  • eBook Packages: Springer Book Archive

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