Abstract
Occasional minute rounded yellow nodules may be seen within the adrenal cortex. The brown patches of ceroid may also be seen grossly.
The lesions found in the adrenals of mice that are thymectomized at birth and kept under specific pathogen-free (SPF) or germ-free conditions to old age consist of (a) ceroid deposits in the cortex, (b) subcapsular spindle-cell hyperplasia, and (c) nodular cortical hyperplasia. The first two are described elsewhere in this volume (pp. 60 and 66); Nodular cortical hyperplasia is described in this section
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Benirschke K, Garner FM, Jones TC (1978) Pathology of laboratory animals. Springer, New York Heidelberg Berlin
Comsa J, Philipp EM, Leonhardt H (1977) Effects of thymectomy on the endocrine glands of the rat. Isr J Med Sci 13: 354 – 362
Cotchin E, Roe FJC (1967) Pathology of laboratory rats and mice. Blackwell, Oxford Edinburgh
Deschaux P, Flores JL, Fontanges R (1974) Influence de la thymectomie sur les glandes surrénales. Arch Int Physiol Biochim 82: 115 – 121
Deschaux P, Massengo B, Fontanges R (1979) Endocrine interaction of the thymus with the hypophysis, adrenals and testes. Thymus 1: 95 – 108
Dobbie JW (1969) Adrenocortical nodular hyperplasia: the ageing adrenal. J Pathol 99: 1 – 18
Dunn TB (1970) Normal and pathologic anatomy of the adrenal gland of the mouse, including neoplasms. JNCI 44: 1323 – 1389
Dunn TB (1979) Tumours of the adrenal gland. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol II, Tumours of the mouse. IARC Sci Pub No.23 Lyon
Hess MW (1968) Experimental thymectomy: Possibilities and limitations. Springer, Berlin
Hess MW, Cottier H, Stoner RD (1963) Primary and secondary antitoxin responses in thymectomized mice. J Immunol 91: 425 – 430
Hullinger RL (1978) Adrenal cortex of the dog (Canis familiaiaris). I. Histomorphologic changes during growth, maturity and aging. Anat Histol Embryol 7: 1 – 27
Jayne EP (1953) Cytology of the adrenal gland of the rat at different ages. Anat Rec 115: 459 – 483
Jayne EP (1963) A histo-cytologic study of the adrenal cortex in mice as influenced by strain, sex, and age. J Gerontol 18: 227 – 234
McIntire KR, Sell S, Miller JF (1964) Pathogenesis of the post-neonatal thymectomy wasting syndrome. Nature 204: 151 – 155
Nelson DH (1980) The adrenal cortex: Physiological function and disease, vol XVII Major problems in internal medicine. Saunders, Philadelphia
Neville AM, O’Hare MJ (1982) The human adrenal cortex. Springer, Berlin Heidelberg New York
Pierpaoli W, Besedovsky HO (1975) Role of the thymus in programming of neuroendocrine functions. Clin Exp Immunol 20: 323 – 328
Pierpaoli W, Sorkin E (1972) Alterations of adrenal cortex and thyroid in mice with congenital absence of the thymus. Nature 238: 282 – 285
Walter JB, Israel MS (1979) General pathology, 5th edn. Churchill-Livingstone Edinburgh London New York
Woolley GW, Little CC (1945) The incidence of adrenal cortical carcinoma in gonadectomized female mice of the extreme dilution strain. I. Observations on the adrenal cortex. Cancer Res 5: 193–202
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Zak, F. (1983). Nodular Cortical Hyperplasia, Adrenal, Thymectomized Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D., Capen, C.C. (eds) Endocrine System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96720-7_19
Download citation
DOI: https://doi.org/10.1007/978-3-642-96720-7_19
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-96722-1
Online ISBN: 978-3-642-96720-7
eBook Packages: Springer Book Archive