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Nodular Cortical Hyperplasia, Adrenal, Thymectomized Mouse

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Endocrine System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

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Abstract

Occasional minute rounded yellow nodules may be seen within the adrenal cortex. The brown patches of ceroid may also be seen grossly.

The lesions found in the adrenals of mice that are thymectomized at birth and kept under specific pathogen-free (SPF) or germ-free conditions to old age consist of (a) ceroid deposits in the cortex, (b) subcapsular spindle-cell hyperplasia, and (c) nodular cortical hyperplasia. The first two are described elsewhere in this volume (pp. 60 and 66); Nodular cortical hyperplasia is described in this section

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References

  • Benirschke K, Garner FM, Jones TC (1978) Pathology of laboratory animals. Springer, New York Heidelberg Berlin

    Book  Google Scholar 

  • Comsa J, Philipp EM, Leonhardt H (1977) Effects of thymectomy on the endocrine glands of the rat. Isr J Med Sci 13: 354 – 362

    PubMed  CAS  Google Scholar 

  • Cotchin E, Roe FJC (1967) Pathology of laboratory rats and mice. Blackwell, Oxford Edinburgh

    Google Scholar 

  • Deschaux P, Flores JL, Fontanges R (1974) Influence de la thymectomie sur les glandes surrénales. Arch Int Physiol Biochim 82: 115 – 121

    Article  PubMed  CAS  Google Scholar 

  • Deschaux P, Massengo B, Fontanges R (1979) Endocrine interaction of the thymus with the hypophysis, adrenals and testes. Thymus 1: 95 – 108

    PubMed  CAS  Google Scholar 

  • Dobbie JW (1969) Adrenocortical nodular hyperplasia: the ageing adrenal. J Pathol 99: 1 – 18

    Article  PubMed  CAS  Google Scholar 

  • Dunn TB (1970) Normal and pathologic anatomy of the adrenal gland of the mouse, including neoplasms. JNCI 44: 1323 – 1389

    PubMed  CAS  Google Scholar 

  • Dunn TB (1979) Tumours of the adrenal gland. In: Turusov VS (ed) Pathology of tumours in laboratory animals, vol II, Tumours of the mouse. IARC Sci Pub No.23 Lyon

    Google Scholar 

  • Hess MW (1968) Experimental thymectomy: Possibilities and limitations. Springer, Berlin

    Google Scholar 

  • Hess MW, Cottier H, Stoner RD (1963) Primary and secondary antitoxin responses in thymectomized mice. J Immunol 91: 425 – 430

    PubMed  CAS  Google Scholar 

  • Hullinger RL (1978) Adrenal cortex of the dog (Canis familiaiaris). I. Histomorphologic changes during growth, maturity and aging. Anat Histol Embryol 7: 1 – 27

    Article  PubMed  CAS  Google Scholar 

  • Jayne EP (1953) Cytology of the adrenal gland of the rat at different ages. Anat Rec 115: 459 – 483

    Article  PubMed  CAS  Google Scholar 

  • Jayne EP (1963) A histo-cytologic study of the adrenal cortex in mice as influenced by strain, sex, and age. J Gerontol 18: 227 – 234

    PubMed  CAS  Google Scholar 

  • McIntire KR, Sell S, Miller JF (1964) Pathogenesis of the post-neonatal thymectomy wasting syndrome. Nature 204: 151 – 155

    Article  PubMed  CAS  Google Scholar 

  • Nelson DH (1980) The adrenal cortex: Physiological function and disease, vol XVII Major problems in internal medicine. Saunders, Philadelphia

    Google Scholar 

  • Neville AM, O’Hare MJ (1982) The human adrenal cortex. Springer, Berlin Heidelberg New York

    Book  Google Scholar 

  • Pierpaoli W, Besedovsky HO (1975) Role of the thymus in programming of neuroendocrine functions. Clin Exp Immunol 20: 323 – 328

    PubMed  CAS  Google Scholar 

  • Pierpaoli W, Sorkin E (1972) Alterations of adrenal cortex and thyroid in mice with congenital absence of the thymus. Nature 238: 282 – 285

    Article  CAS  Google Scholar 

  • Walter JB, Israel MS (1979) General pathology, 5th edn. Churchill-Livingstone Edinburgh London New York

    Google Scholar 

  • Woolley GW, Little CC (1945) The incidence of adrenal cortical carcinoma in gonadectomized female mice of the extreme dilution strain. I. Observations on the adrenal cortex. Cancer Res 5: 193–202

    Google Scholar 

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© 1983 Springer-Verlag Berlin Heidelberg

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Zak, F. (1983). Nodular Cortical Hyperplasia, Adrenal, Thymectomized Mouse. In: Jones, T.C., Mohr, U., Hunt, R.D., Capen, C.C. (eds) Endocrine System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96720-7_19

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  • DOI: https://doi.org/10.1007/978-3-642-96720-7_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-96722-1

  • Online ISBN: 978-3-642-96720-7

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