Abstract
The nervous system - the subject of the first part of this book - is composed of nerve cells or neurons. The human brain contains about 25 billion such nerve cells; it, together with the spinal cord, constitutes the central nervous system (CNS). Only about 25 million nerve cells lie in the periphery or connect the periphery to the central nervous system. The nerve cells communicate with one another in a variety of ways by synapses, which far outnumber (by about a thousand-fold) the nerve cells. Synaptic contacts are also made with other types of cell, in particular receptors (information-receiving cells - e. g., in the sense organs) and effectors (e.g., the muscle cells). Because receptors and muscle cells have many functional features in common with the nerve cells, they will also be discussed in this part of the book.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Textbooks and Handbooks
Davson, H.: A Textbook of General Physiology, 4th Ed. London: Churchill 1970
Handbook of Physiology. I The Nervous System. Vol. 1 Cellular Biology of Neurons. Kandel, E.R. (Ed.) Baltimore: Williams & Wilkins 1977
Katz, B.: Nerve, Muscle and Synapse. New York: McGraw-Hill 1966
Kuffler, S.W., Nicholls, J.G.: From Neuron to Brain. Sunderland, Mass.: Sinauer Associates, Inc. 1976
Ruch, T.C., Patton, H.D.: Physiology and Biophysics. Philadelphia: Saunders 1966
Cooke, I., Lipkin, M.: Cellular Neurophysiology, a Source Book. New York: Holt, Rinehart and Winston 1972 (Collection of important original publications)
Research Reports and Reviews
Adrian, R. H.: The effect of internal and external potassium concentration on the membrane potential of frog muscle. J. Physiol. (Lond.) 133,631 (1956)
Adrian, R.H., Freygang, W.H.: The potassium and chloride conductance of frog muscle membrane. J. Physiol. (Lond.) 163,61 (1962)
Berthold, C. H.: Morphology of normal peripheral axons. In: Physiology and Pathobiology of Axons. Waxman, S.G. (Ed.) New York: Raven Press 1978
Cahalan, M.: Voltage clamp studies on the node of Ranvier. In: Physiology and Pathobiology of Axons. Waxman, S.G. (Ed.) New York: Raven Press 1978
Carpenter, D.O., Alving, B.O.: A contribution of an electrogenic Na+ pump to membrane potential in Aplysia neurons. J. gen. Physiol. 52, 1 (1968)
Dudel, J., Trautwein, W.: Elektrophysiologische Messungen zur Strophantinwirkung am Herzmuskel. Arch, exper. Path. Pharmakol. 232, 393(1958)
Eccles, J.C.: The Physiology of Nerve Cells. Baltimore: Johns Hopkins Press 1957
Frankenhaeuser, B., Hodgkin, A. L.: The action of calcium on the electrical properties of squid axons. J. Physiol. (Lond.) 137, 218 (1957)
Frankenhaeuser, B., Huxley, A. F.: Action potential in myelinated nerve fibre of Xenopus laevis as computed on basis of voltage clamp data. J. Physiol. (Lond.) 171, 302 (1964)
Gasser, H.S., Grundfest, H.: Axon diameters in relation to the spike dimensions and the conduction velocity in mammalian A- fibers. Amer. J. Physiol. 127, 393 (1939)
Hille, B.: The permeability of the sodium channel to metal cations in myelinated nerve. J. gen. Physiol. 59, 637 (1972)
Hille, B.: Ionic channels in excitable membranes. Biophys. J. 22, 283–294(1978)
Hodgkin, A. L., Horowicz, P.: The effect of sudden changes in ionic concentrations on the membrane potential of single muscle fibres. J. Physiol. (Lond.) 153, 370 (1960)
Hodgkin, A. L., Huxley, A. F.: Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo. J. Physiol. (Lond.) 116, 449 (1952)
Hodgkin, A. L., Huxley, A. F.: The components of membrane conductance in the giant axon of Loligo. J. Physiol. (Lond.) 116, 473 (1952)
Hodgkin, A. L., Huxley, A. F.: The dual effect of membrane potential on sodium conductance in the giant axon of Loligo. J. Physiol. (Lond.) 116, 497 (1952)
Hodgkin, A.L., Huxley, A.F.: Quantitative description of membrane current and its application to conduction and excitation in nerve. J. Physiol. (Lond.) 117, 500 (1952)
Hodgkin, A.L., Keynes, R.D.: Active transport of cations in giant axons from Sepia and Loligo. J. Physiol. (Lond.) 128, 28 (1955)
Hodgkin, A.L., Rushton, W.A.H.: The electrical constants of a crustacean nerve fibre. Proc. roy. Soc. B133, 444 (1946)
Huxley, A.F., Stámpfli, R.: Evidence for saltatory conduction in peripheral myelinated nerve fibres. J. Physiol. (Lond.) 108, 315 (1949)
Hoffman, J. F.: Molecular mechanism of active cation transport. In: Biophysics of Physiological and Pharmacological Actions (Shanes, Ed.) Washington: Amer. Ass. Adv. Sci. 1961
Katz, B.: Electrical properties of the muscle fibre membrane. Proc. roy. Soc. B135, 506 (1948)
Kuffler, S.W.: Mechanism of activation and motor control of stretch receptors in lobster and crayfish. J. Neurophysiol. 17, 558 (1954)
Lloyd, D.P.C., Chang, H.T.: Afferent fibers in muscle nerves. J. Neurophysiol. 11,199 (1948)
Lux, H.D.: Simultaneous measurement of extracellular potassium- ion activity and membrane currents in snail neurons. In: Ion and Enzyme Electrodes in Biology and Medicine. Kessler, R. (Ed.) Munich: Urban and Schwarzenberg 1976
Mullins, L. J., Awad, M.Z.: The control of the membrane potential of muscle fibers by the sodium pump. J. gen Physiol. 48,761 (1965)
Narahashi, T.: Mechanism of action of tetrodotoxin and saxitoxin on excitable membranes. Fed. Proc. 31, 1124 (1972)
Narahashi, T., Moore, J.W.: Neuroactive agents and nerve membrane conductances. J. gen. Physiol. 51, 93 (1968)
Noble, D.: Applications of Hodgkin-Huxley equations to excitable tissues. Physiol. Rev. 46, 1 (1966)
Ochs, S., Worth, R. M.: Axoplasmic transport in normal and pathological systems. In: Physiology and Pathology of Axons. Waxman, S. G. (Ed.) New York: Raven Press 1978
Rang, H. P., Ritchie, J. M.: Electrogenic sodium pump in mammalian non-myelinated nerve fibres and its activation by various external cations. J. Physiol. (Lond.) 196, 183 (1968)
Stámpfli, R., Hille, B.: Electrophysiology of frog peripheral myelinated nerve. In: Neurobiology of the Frog. Llinas, R., Precht, W. (Eds.) New York: Springer 1977
Terzuolo, C. A., Washizu, Y.: Relation between stimulus strength, generator potential and impulse frequency in stretch receptor of crustacea. J. Neurophysiol. 25, 56 (1962)
Thomas, R. C.: Electrogenic sodium pump in nerve and muscle cells. Physiol. Rev. 52, 563–594 (1972)
Trachtenberg, N.C., Pollen, D. A.: Neuroglia biophysical properties in physiologic function. Science 67, 1248 (1970)
Ulbricht, W.: Ionic channels and gating currents in excitable membranes. Ann. Rev. Biophys. Bioeng. 6, 7–31 (1977)
Watson, W. E.: Physiology of neuroglia. Physiol. Rev. 54, 245 (1974)
Weidmann, S.: Effects of calcium ions and local anaesthetics on electrical properties of Purkinje fibres. J. Physiol. (Lond.) 129, 568 (1955)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1983 Springer-Verlag Berlin · Heidelberg
About this chapter
Cite this chapter
Dudel, J. (1983). Function of Nerve Cells. In: Schmidt, R.F., Thews, G. (eds) Human Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96714-6_1
Download citation
DOI: https://doi.org/10.1007/978-3-642-96714-6_1
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-96716-0
Online ISBN: 978-3-642-96714-6
eBook Packages: Springer Book Archive