Abstract
That the immune response to an immunogen by an individual animal is under genetic control is evident from the results of several studies. For example, Fjord-Scheibel (1943), Carlifanti (1948), and Sang and Sobey (1954) showed a statistically significant relationship between the abilities of parents and their offspring to produce high serum titers of antibody to a given immunogen. Also, Ibsen (1959) showed that inbred strains of mice required different doses of antigen to produce a standardized immune response. Recently, Sobey et al. (1966) observed genetically transmissable differences among random bred mice to respond immunologically to bovine serum albumin. Finally, Arquilla and Finn (1965), in studies of the immune response of inbred guinea pigs to bovine insulin, found that strain 2 guinea pigs could make antibodies to an antigenic determinant of insulin to which strain 13 could not make antibodies. However, breeding studies showed complex patterns of inheritance.
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References
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Levine, B.B., Green, I., Benacerraf, B. (1968). The Genetic Control of the Immune Response to Hapten-Poly-L Lysine Conjugates in Guinea Pigs. In: Plescia, O.J., Braun, W. (eds) Nucleic Acids in Immunology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-87668-4_18
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