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Germinal Center Activity in Relation to Delayed Hypersensitivity

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Germinal Centers in Immune Responses

Abstract

For many years it was considered by some people that delayed hypersensitivity and circulating antibody production were closely linked phenomena. Moreover, it was even thought by some that delayed hypersensitivity was an essential step in the process of antibody formation (Salvin and Smith, 1960).

Supported by the Netherlands Organization for the Advancement of Pure Research (Z.W.O.).

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References

References

  • Andre, J. A., R. S. Schwartz, W. J. Mitus, and W. Dameshek: The morphologic responses of the lymphoid system to homografts. I. First and second set responses in normal rabbits. Blood 19, 313–333 (1962).

    PubMed  CAS  Google Scholar 

  • Asherson, G. L., and S. H. Stone: Selective and specific inhibition of 24 hour skin reactions in the guinea pig. I. Immune deviation: Description of the phenomenon and the effect of splenectomy. Immunology 9, 205–217 (1965).

    PubMed  CAS  Google Scholar 

  • Battisto, J. R., and M. W. Chase: Induced unresponsiveness to simple allergenic diemicals. II. Independence of delayed-type hypersensitivity and formation of circulating antibody. J. exp. Med. 121, 591–606 (1965).

    Article  PubMed  CAS  Google Scholar 

  • Borel, Y., M. Fauconnet, and P. A. Miescher: Selective suppression of delayed hypersensitivity by the induction of immunologic tolerance. J. exp. Med. 123, 585–598 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Congdon, C. C: Effect of injection of foreign bone marrow on the lymphatic tissues of normal mice. J. nat. Cancer Inst. 28, 305–322 (1962).

    PubMed  CAS  Google Scholar 

  • Coons, A. H., E. H. Leduc, and J. M. Connolly: Studies on antibody production. I. A method for the histodiemical demonstration of specific antibody and its application to a study of the hyperimmune rabbit. J. exp. Med. 102, 49–60 (1955).

    Article  PubMed  CAS  Google Scholar 

  • Fagraeus, A.: Antibody production in relation to the development of plasma cells. In vivo and in vitro experiments. Acta med. scand. 130, Suppl. 204, 7–122 (1948).

    Google Scholar 

  • Fjelde, A., and J. L. Turk: Induction of an immunological response in local lymph nodes by chemical carcinogens. Nature (Lond.) 205, 813–815 (1965).

    Article  CAS  Google Scholar 

  • Oort, J., and J. L. Turk: A histological and autoradiographic study of lymph nodes during the development of contact sensitivity in the guinea pig. Brit. J. exp. Path. 46, 147–154 (1965).

    PubMed  CAS  Google Scholar 

  • Parrott, D. M. v., M. A. B. de Sousa, and J. East: Thymus-dependent areas in the lymphoid organs of neonatally thymectomised mice. J. exp. Med. 123, 191–203 (1966).

    Article  PubMed  CAS  Google Scholar 

  • Salvin, S. B., and R. F. Smith: The specificity of allergic reactions. 1. Delayed versus Arthus hypersensitivity. J. exp. Med. 112, 465–483 (1960).

    Article  Google Scholar 

  • Scothorne, R. J., and I. A. Mcgregor: Cellular changes in lymph nodes and spleen following skin homografting in the rabbit. J. Anat. (Lond.) 89, 283–292 (1955).

    CAS  Google Scholar 

  • Turk, J. L., and J. H. Humphrey: Immunological unresponsiveness in guinea pigs. II. The effect of unresponsiveness on the development of delayed type hypersensitivity to protein antigens. Immunology 4, 309–317 (1961).

    Google Scholar 

  • Turk, J. L., and C. J. Heather: A histological study of lymph nodes during the development of delayed hypersensitivity to soluble antigens. Int. Arch. Allergy 27, 199–212 (1965).

    Article  PubMed  CAS  Google Scholar 

References

  • Medawar, P. B.: Introduction to: “Transplantation of tissues and organs”. Brit. med. Bull. 21, 97–99 (1965).

    Google Scholar 

  • Turk, J. L., and C. J. Heather: A histological study of lymph nodes during the development of delayed hypersensitivity to soluble antigens. Int. Arch. Allergy 27, 199–212 (1965).

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institute of Dermatology, University of London, England

    J. L. Turk

  2. Pathological Laboratory, University of Leiden, The Netherlands

    J. Oort

Authors
  1. J. L. Turk
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  2. J. Oort
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Editor information

Editors and Affiliations

  1. Institute of Pathology, University of Bern, Switzerland

    H. Cottier  & R. Schindler  & 

  2. Swiss Institute for Experimental Cancer Research, Lausanne, Switzerland

    N. Odartchenko  & R. Schindler  & 

  3. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    C. C. Congdon

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© 1967 Springer-Verlag Berlin · Heidelberg

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Turk, J.L., Oort, J. (1967). Germinal Center Activity in Relation to Delayed Hypersensitivity. In: Cottier, H., Odartchenko, N., Schindler, R., Congdon, C.C. (eds) Germinal Centers in Immune Responses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-86837-5_38

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  • DOI: https://doi.org/10.1007/978-3-642-86837-5_38

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-86839-9

  • Online ISBN: 978-3-642-86837-5

  • eBook Packages: Springer Book Archive

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