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Nitrates and Nitrate Tolerance in Angina Pectoris pp 65–76Cite as

Hemodynamic and Ventricular Dynamic Investigations of Nitrate Tolerance

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Abstract

Tolerance to a drug is present if either an increasing dose is necessary in order to obtain a therapeutic effect or there is no efficacy at all. Normally this tolerance disappears after the treatment is discontinued and develops again during a renewed therapy. It is of decisive importance whether a tolerance exists with regard to a particular single effect of the drug or for the therapeutically desirable overall effect. Self-tolerance is the condition whereby a reduction in efficacy develops for the same substance, whereas cross-tolerance is when another similarly acting substance is ineffective.

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Author information

Authors and Affiliations

  1. Medizinische Poliklinik, Universität Erlangen-Nürnberg, Östliche Stadtmauerstr. 29, 8520, Erlangen, Germany

    Priv.-Doz. Dr. W. Niederer

Authors
  1. Priv.-Doz. Dr. W. Niederer
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  2. H. D. Bethge
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  3. K. Bachmann
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Editor information

Editors and Affiliations

  1. Abteilung für Kardiologie, Zentrum Innere Medizin, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Germany

    M. Kaltenbach  & G. Kober  & 

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© 1983 Dr. Dietrich Steinkopff Verlag, GmbH & Co. KG, Darmstadt

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Niederer, W., Bethge, H.D., Bachmann, K. (1983). Hemodynamic and Ventricular Dynamic Investigations of Nitrate Tolerance. In: Kaltenbach, M., Kober, G. (eds) Nitrates and Nitrate Tolerance in Angina Pectoris. Steinkopff. https://doi.org/10.1007/978-3-642-85323-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-85323-4_7

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-642-85325-8

  • Online ISBN: 978-3-642-85323-4

  • eBook Packages: Springer Book Archive

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