Abstract
Infantile cortical hyperostosis in rhesus monkeys (Macaca mulatta) is encountered as a congenital enlargement of the diaphyses of long bone. Enlargements, or hyperostoses, are typically hard, bilaterally symmetric and widest at the mid-diaphysis (Fig. 128). The periosteum is mildly to moderately thickened and overlying soft tissues are atrophic, fibrotic and difficult to dissect from underlying bone. Longitudinal sections of long bones reveal morphologically normal epiphysis and physis. Cross-sections through affected diaphyses reveal a relatively normal medullary cavity with discernable cortical bone surrounded by hyperostotic proliferations. Gross features are particularly striking in radiographs (Fig. 129). Lesions are restricted to the musculoskeletal system.
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References
Aegerter E, Kirkpatrick JA Jr (1975) Infantile cortical hyperostosis. In: Aegerter E, Kirkpatrick JA Jr (eds) Orthopedic diseases. Saunders, Philadelphia, p 70
Baker JR (1975) Bone disease in a dog similar to infantile cortical hyperostosis (Caffey’s disease). Vet Rec 97: 74–75
Cicmanec JL, Enlow DH, Cohen BJ (1972) Polyostotic osteophytosis in a rhesus monkey. Lab Anim Sci 22: 237–241
Doige C (1988) In: Thompson RG (ed) Special veterinary pathology. Decker, Toronto, pp 486–487
Kaye MM (1962) Hyperostosis in newborn pigs. Can J Comp Med Vet Sci 26:218–221
Marshall GS, Edwards KM, Wadlington WB (1987) Sporadic congenital Caffey’s disease. Clin Pediatr 26:177–180
Potter LE, Craig JM (1976) Pathology of the fetus and infant, 3rd edn, Year Book Medical Publishers, Chicago, pp 568–569
Saul RA, Lee WH, Stevenson RE (1982) Caffey’s disease revisited. Further evidence for autosomal dominant inheritance with incomplete penetrance. Am J Dis Child 136:55–60
Snook SS, King NW (1989) Familial infantile cortical hyperostosis (Caffey’s disease) in rhesus monkeys (Macaca mulatta). Vet Pathol 26:274–277
Staheli LT, Church CC, Ward BH (1968) Infantile cortical hyperostosis (Caffey’s disease). Sixteen cases with a late follow-up of eight. J Am Med Assoc 203:384–388
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© 1993 Springer-Verlag Berlin Heidelberg
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Snook, S.S. (1993). Infantile Cortical Hyperostosis, Rhesus Monkey. In: Jones, T.C., Mohr, U., Hunt, R.D. (eds) Nonhuman Primates. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84924-4_25
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DOI: https://doi.org/10.1007/978-3-642-84924-4_25
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