The Influence of Blood Supply and Loading Upon the Shape-Forming Processes in Bones and Joints

Abstract

Our clinical and experimental work has demonstrated the influence that both blood supply and loading have upon the shape-forming processes in bones and joints. Specifically, both the shape and the mass of bone are dependent upon an interaction between mechanical loading and blood supply. A simultaneous increase of both load and blood supply causes bone mass to increase. In situations where circulation is adequate but there is minimal loading, bone mass diminishes (disuse osteoporosis). Likewise, a decrease in blood supply with preservation of normal loading also leads to a decrease in bone mass.