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Klinisch orientierte Grundlagenforschung

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Aktuelle Therapie des Prostatakarzinoms
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Zusammenfassung

Weltweit beschäftigen sich Arbeitsgruppen mit der Aufklärung möglicher Mechanismen der Tumorentstehung. Aus der Molekulargenetik kamen in den letzten Jahren eine Vielzahl von Informationen, welche zur Diskussion von Onkogenen als zentrale Initiatoren der malignen Transformation führten (Weinberg 1984; Slaman et al. 1984).

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Literatur

  • Atkins NB (1974) Chromosomes in human malignant tumors: a review and assessment. Germin J (ed) Chromosomes and cancer. Wiley, New York, pp 375–412

    Google Scholar 

  • Baldwin RW, Buyers VS (1986) Monoclonal antibody targeting of anti-cancer agents. Semin Immunopathol 9: 39–50

    CAS  Google Scholar 

  • Barrack ER, Bujnovsky P, Walsh PC (1983) Subcellular distribution of androgen receptors in human normal, benign hyperplastic and malignant prostatic tissue: Characterization of nuclear salt-resistent receptors, Cancer Res 43: 1107–1116

    PubMed  CAS  Google Scholar 

  • Bishop JM (1981) oncogenes. Sci Am 246: 68–78 (Cell 23, 5)

    Google Scholar 

  • Brendler CB, Follansbee AL, Isaacs JT (1985) Discrimination between normal hyperplastic and malignant human prostatic tissue by enzymatic profiles. J Urol 133: 495–501

    PubMed  CAS  Google Scholar 

  • Davies P, Thomas P, Griffith K (1977) Measurement of free and occupied cytoplasmatic and nuclear androgen receptor sites in rat ventral prostate gland. J Endocrinol 74: 393–404

    Article  PubMed  CAS  Google Scholar 

  • Ellis DW, Leffers S, Stewart Davies J, Ng ABP (1984) Multiple immunoperoxidase markers in benign hyperplasia and adenocarcinoma of the prostate. Am J Clin Pathol 81: 279–284

    PubMed  CAS  Google Scholar 

  • Frankel AE, Ronse RV, Wang MC (1982) Monoclonal antibodies to a human prostate antigen. Cancer Res 42: 3714–3718

    PubMed  CAS  Google Scholar 

  • Frankfurt OS, Chin JL, Englander LS (1985) Relationship between DNA-ploidy, glandular differentiation and tumor spread in human prostate cancer Cancer Res 45: 1418–1423

    PubMed  CAS  Google Scholar 

  • Ford TF, Butcher, DN, Masters JRW, Parkinson MC (1985) Immuncytochemical localisation of prostate-specific antigen: specificity and application to clinical practice. Br J Urol 57: 50–55

    Article  PubMed  CAS  Google Scholar 

  • Goldenberg DM, Deland FH (1984) Clinical studies of prostatic cancer imaging with radiolabelled antibodies against prostatic acid phosphatase. Urol Clin North Am 11: 277–281

    PubMed  CAS  Google Scholar 

  • Goldenberg JM, Deland FH, Bewett SJ (1983) Radioimmunodetection of prostatic cancer. In vivo use of radioactive antibodies against prostatic acid phosphatase for diagnosis and detection of prostatic cancer by nuclear imaging. J Am Med Assoc 250: 630–635

    Article  CAS  Google Scholar 

  • Gutman AB, Gutman ED (1938) An acid phosphatase occuring in the serum of patients with metastasizing carcinoma of the prostate gland. J Clin Invest 17: 473–480

    Article  PubMed  CAS  Google Scholar 

  • Huggins C, Clark PJ (1940) Quantitative studies for prostatic secretion EL The effect of castration and of estrogen injection on the normal and on the hyperplasia prostatic glands of dogs. J Exp Med 72: 7474–758

    Article  Google Scholar 

  • Huggins C, Hodges CV (1941) Studies on prostatic cancer. 1. The effect of castration, of estrogen and of androgen injection on serum-phosphatases in metastatic cancer of the prostata. Cancer Res 1: 293–297

    CAS  Google Scholar 

  • Lad PH, Cooper JF, Learn DB, Olson CV (1984) Identification of structural and secretary lectin-binding glycoprotein of normal and cancerous human prostate. Biochim Biophys Act Ser Protein Struct Mol Enzymol 791: 186–197

    Article  CAS  Google Scholar 

  • Maatman TJ, Gupta MK, Montie JE (1984) The role of serum prostatic acid phosphatase as a tumor marker in men with advanced carcinoma of the prostate. J Urol 132: 58–60

    PubMed  CAS  Google Scholar 

  • Pappas AA, Gadsden RH (1984) Prostatic acid phosphatase: clinical utility in detection, assessment and monitory carcinoma of the prostate. Ann Clin Lab Sci 14: 285–291

    PubMed  CAS  Google Scholar 

  • Pontes JE (1983) Biological markers in prostatic cancer. J Urol 130: 1037–1047

    PubMed  CAS  Google Scholar 

  • Raynar RH, Hazra TA, Moncure CW, Mohanakumar T (1984) Characterization of a monoclonal antibody K,R P8, that detects a new prostate-specific marker. J Natl Cancer Inst 73: 617–625

    Google Scholar 

  • Reddy EP (1983) Nucleotide sequence analysis of the T24 human bladder. Carcinoma Oncog Sci 220: 1061–63

    CAS  Google Scholar 

  • Schacht MJ, Garnett JE, Grayhack JT (1984) Biochemical markers in prostatic carcinoma. Urol Clin North Am 11: 253–267

    PubMed  CAS  Google Scholar 

  • Slaman DJ, DeKernion JB, Verma JM, Cline JM (1984) Expression of cellular oncogenes in human malignancies. Science 224: 256–262

    Article  Google Scholar 

  • Sukamar S, Pulciani S, Barbacid M (1984) A transforming ras-gene in guinea-pig cell lines initiated by diverse chemical carcinogens. Science 3: 1197–1199

    Article  Google Scholar 

  • de Voogt HJ, Dinggan P (1978) Steroid receptors in human prostatic cancer. Urol Res 6: 151–155

    Article  PubMed  Google Scholar 

  • Webb KS, Wave JL, Parks SF (1983) Monoclonal antibodies to different epitopes on a prostate tumor-associated antigen. Implications for immunotherapy. Cancer Immunol Immunother 14: 155–166

    Article  PubMed  CAS  Google Scholar 

  • Weinberg RA (1984) Cellular oncogeries. TIBS 4. Elsevier Science, Amsterdam, pp 131–133

    Google Scholar 

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© 1991 Springer-Verlag Berlin Heidelberg

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Schärfe, T. (1991). Klinisch orientierte Grundlagenforschung. In: Ackermann, R., Altwein, J.E., Faul, P. (eds) Aktuelle Therapie des Prostatakarzinoms. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84264-1_22

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  • DOI: https://doi.org/10.1007/978-3-642-84264-1_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84265-8

  • Online ISBN: 978-3-642-84264-1

  • eBook Packages: Springer Book Archive

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