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Adjuvant Therapy of Primary Breast Cancer pp 118–125Cite as

Adjuvant Chemo- and Endocrine Therapy Alone or in Combination in Premenopausal Patients (GABG Trial 1)

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Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 115))

Abstract

The natural history of operable breast cancer can be affected by adjuvant treatment (Lippman 1986; Salmon 1987). Adjuvant combination chemotherapy, e.g., cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) results in a significant prolongation of disease-free (DFS) and overall survival (OS) in premenopausal node-positive patients. These data were mainly obtained by overview analyses of randomized trials with treatment groups as compared with no adjuvant therapy (control) after mastectomy.

This work was partially supported by grants from ICI-Pharma, Plankstadt, FRG, and Farmitalia Carlo Erba, Freiburg, FRG.

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References

  • Anonymous (1987) Adjuvant tamoxifen in early breast cancer. Lancet ii: 191–192

    Google Scholar 

  • Bonadonna G, Brusamolino E, Valagussa P et al. (1976) Combination chemotherapy as an adjuvant treatment in operable breast cancer. N Engl J Med 294: 405–410

    Article  PubMed  CAS  Google Scholar 

  • Bonadonna G, Valagussa P (1985) Adjuvant systemic therapy for resectable breast cancer. J Clin Oncol 3: 259–275

    PubMed  CAS  Google Scholar 

  • Bonadonna G, Valagussa P (1986) Adjuvant chemoendocrine therapy in breast cancer. J Clin Oncol 4: 451–454

    PubMed  CAS  Google Scholar 

  • Consensus Conference (1985) Adjuvant chemotherapy for breast cancer. JAMA 254: 3461–3463

    Article  Google Scholar 

  • EORTC: Breast Cancer Cooperative Group (1973) Standards for the assessment of estrogen receptors in human breast cancer. Eur J Cancer Clin Oncol 9: 379–381

    Google Scholar 

  • Fisher B, Redmond C, Brown A et al. (1981) Treatment of primary breast cancer with chemotherapy and tamoxifen. N Engl J Med 305: 1–6

    Article  PubMed  CAS  Google Scholar 

  • Fisher B, Redmond C, Brown A et al. (1986) Adjuvant chemotherapy with and without tamoxifen in the treatment of primary breast cancer: 5-year results from the National Surgical Adjuvant Breast and Bowel Project Trial. J Clin Oncol 4: 459–471

    PubMed  CAS  Google Scholar 

  • Fisher ER, Sass R, Fisher B et al. (1987) Pathologic findings from the National Surgical Adjuvant Breast Project: Correlations with concordant and discordant estrogen and progesterone receptors. Cancer 59: 1554–1559

    Article  PubMed  CAS  Google Scholar 

  • Gelber RD, Goldhirsch A for the Ludwig Breast Cancer Study Group (1986) A new endpoint for the assessment of adjuvant therapy in postmenopausal women with operable breast cancer. J Clin Oncol 4: 1772–1779

    PubMed  CAS  Google Scholar 

  • Hubay C, Pearson OH, Marshall US et al. (1980) Antiestrogen, cytotoxic chemotherapy and bacillus Calmette-Guerain vaccination in stage II breast cancer: a preliminary report. Surgery 87: 494–501

    PubMed  CAS  Google Scholar 

  • Kaplan EL, Meier P (1958) Nonparametric estimation from incomplete observations. J Am Statis Assoc 53: 457–481

    Article  Google Scholar 

  • Kaufmann M (1983) Biochemische prognostische Faktoren beim Mamma-Karzinom. In: Kubli F, Nagel GA, Kadach U, Kaufmann M (eds) Neue Wege in der Brustkrebsbehandlung. Zuckschwerdt, Munich, pp 46–61 (Aktuelle onkologie, vol 8 )

    Google Scholar 

  • Kaufmann M, Jonat W et al. (GABG) (1984) Risk adapted adjuvant chemo-hormonotherapy in operable nodal positive breast cancer. In: Jones SE, Salmon SE (eds) (1984) Adjuvant therapy of cancer, vol 4. Grune and Stratton, New York, pp 369–378

    Google Scholar 

  • Kaufmann M, Jonat W, Caffier H, Hilfrich J, Melchert F, Mahlke M, Abel U, Maass H, Kubli F for the Gynecological Adjuvant Breast Cancer Group (1985) Adjuvant chemo-hormonotherapy selected by axillary node and hormone receptor status in node-positive breast cancer. Reviews Endocrine-Related Cancer 17: [Suppl] 57–63

    Google Scholar 

  • Meakin JW (1986) Review of Canadian Trials of adjuvant endocrine therapy for breast cancer. NCI Monogr 1: 111–113

    PubMed  Google Scholar 

  • Lippman ME (ed) (1986) NIH Consensus Development Conference on adjuvant chemotherapy and endocrine therapy breast cancer 1985. NCI Monogr 1

    Google Scholar 

  • Ludwig Breast Cancer Study Group (1984) Randomized trial of chemo-endocrine therapy, endocrine therapy and mastectomy alone in postmenopausal patients with operable breast cancer and axillary node metastases. Lancet i: 1256–1260

    Google Scholar 

  • Ludwig Breast Cancer Study Group (1985) Chemotherapy with or without oophorectomy high-risk premenopausal patients with operable breast cancer. J Clin Oncol 3: 1059–1067

    Google Scholar 

  • Nolvadex Adjuvant Trial Organization (NATO) (1985) Controlled trial of tamoxifen as single adjuvant agent in management of early breast cancer. Analysis at six years. Lancet i: 836–840

    Google Scholar 

  • Padmanabhan N, Wang DY, Moore JW, Rubens RD (1987) Ovarian function and adjuvant chemotherapy for early breast cancer. Eur J Cancer Clin Oncol 23: 745–748

    Article  PubMed  CAS  Google Scholar 

  • Peto R, Pike MC, Armitage P et al. (1977) Design and analysis of randomized clinical trials requiring prolonged observation of each patient. Analysis and examples. Br J Cancer 35: 1–39

    Article  PubMed  CAS  Google Scholar 

  • Rose C, Thorpe S, Anderson KW et al (1985) Beneficial effect of adjuvant tamoxifen therapy in primary breast cancer patients with high oestrogen receptor value. Lancet i: 16–19

    Article  Google Scholar 

  • Salmon SE (ed) (1987) Adjuvant therapy of cancer, vol 5. Grune and Stratton, New York

    Google Scholar 

  • Salmon SE, Jones SE (1979) Studies of the combination of adriamycin and cyclophosphamide (alone or with other agents) for the treatment of breast cancer. Oncology 36: 40–44

    Google Scholar 

  • Scottish Cancer Trial (1987) Adjuvant tamoxifen in the management of operable breast cancer: The Scottish Trial. Lancet ii: 171–175

    Google Scholar 

  • Wilson RE, Donegan WL, Mettlin C et al. (1984) The 1982 national survey of carcinoma of the breast in the United States. Surg Gynecol Obstet 159: 309–318

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Abteilung für Gynäkologie und Geburtshilfe, Universität Heidelberg, Voßstraße 9, 6900, Heidelberg, Germany

    M. Kaufmann, W. Jonat & U. Abel

Authors
  1. M. Kaufmann
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  2. W. Jonat
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  3. U. Abel
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Editor information

Editors and Affiliations

  1. Medizinische Klinik C, Kantonsspital, 9007, St. Gallen, Switzerland

    Hans-Jörg Senn

  2. Servizio Oncologico Cantonale, Ospedale Civico, 6900, Lugano, Switzerland

    Aron Goldhirsch

  3. Division of Biostatistics and Epidemiology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA, 02115, USA

    Richard D. Gelber

  4. Abteilung für Hämatologie und Onkologie Medizinische Klinik C, Kantonsspital, 9007, St. Gallen, Switzerland

    Bruno Osterwalder

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© 1989 Springer-Verlag Berlin · Heidelberg

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Kaufmann, M., Jonat, W., Abel, U. (1989). Adjuvant Chemo- and Endocrine Therapy Alone or in Combination in Premenopausal Patients (GABG Trial 1). In: Senn, HJ., Goldhirsch, A., Gelber, R.D., Osterwalder, B. (eds) Adjuvant Therapy of Primary Breast Cancer. Recent Results in Cancer Research, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83337-3_17

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  • DOI: https://doi.org/10.1007/978-3-642-83337-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83339-7

  • Online ISBN: 978-3-642-83337-3

  • eBook Packages: Springer Book Archive

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