Abstract
Resistance is a general term describing the insensitivity of tumors to treatment. A large amount of research has gone into classifying various biological mechanism which can give rise to resistance to chemotherapy. Various mechanisms have been recognized. Some have been found to operate at the cellular level and some have been found to be due to tumor architecture or location. The importance of each mechanism in explaining the insensitivity of human tumors to chemotherapy is not known, and may vary from site to site. However, the general implications of each mechanism is important and merits detailed investigation.
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© 1986 Springer-Verlag Berlin Heidelberg
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Coldman, A.J., Goldie, J.H. (1986). Factors Affecting the Development of Permanent Drug Resistance and Its Impact upon Neoadjuvant Chemotherapy. In: Ragaz, J., Band, P.R., Goldie, J.H. (eds) Preoperative (Neoadjuvant) Chemotherapy. Recent Results in Cancer Research, vol 103. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-82671-9_7
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DOI: https://doi.org/10.1007/978-3-642-82671-9_7
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