Summary
Severe incomplete cerebral ischemia of 30 min duration with CBF below 5% of normal was induced in rats by clamping both carotids and lowering BP. One group of rats were fasting (f-rats), while the other was infused with glucose before induction of the ischemia (g-rats). In f-rats the lactate accumulating in the cerebral cortex was about 15 μmol · g-1, whereas in g-rats it rose to about 35 μmol · g-1. In f-rats considerable recovery of the energy state and electrical activity occurred during recirculation, whereas in g-rats the energy failure persisted with no electrical activity reappearing. In f-rats the structural alterations were of minor severity, but in g-rats extensive progressive tissue damage was seen. The data indicate that the degree of tissue lactic acidosis has pronounced effects on the development of irreversible ischemic nerve cells injury.
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© 1981 Springer-Verlag
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Kalimo, H., Rehncrona, S., Söderfeldt, B. (1981). The Role of Lactic Acidosis in the Ischemic Nerve Cell Injury. In: Jellinger, K., Gullotta, F., Mossakowski, M. (eds) Experimental and Clinical Neuropathology. Acta Neuropathologica Supplementum, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81553-9_6
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DOI: https://doi.org/10.1007/978-3-642-81553-9_6
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