Abstract
This symposium is a special delight for one of those who benefited from Dr. Lipmannās kindness in accepting graduate students after his move to New York in 1957. By then he had numerous scientific progeny, and my relationship to him is complicated by the fact that I can also count myself among his scientific grandchildren through apprenticeships with Hans Bomann and Bill Jencks. A good deal of what I am going to say, about enzyme interactions with high energy intermediates in substrate transformation, had its genesis in conversations about group potential (Lipmann 1941) and in some ideas expressed a generation later by Jencks (1966) in a volume commemorating the 1941 review.
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Wolfenden, R. (1980). Influences of Solvent Water on the Transition State Affinity of Enzymes, Protein Folding, and the Composition of the Genetic Code. In: Chapeville, F., Haenni, AL. (eds) Chemical Recognition in Biology. Molecular Biology, Biochemistry and Biophysics, vol 32. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81503-4_4
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