Abstract
Serum from BCG-infected mice that receive a lethal dose of LPS induces necrosis of a variety of transplanted mouse tumors. This serum (TNS) was shown to protect mice against two types of infectious challenges, Klebsiella and Listeria organisms. The antimicrobial activity was also demonstrated in adult C3H/He mice and in newborn mice, which are known to be refractory to the LPS-mediated increase in nonspecific resistance to infections.
This work was supported in part by research grant 79/339 from the Direction des Recherches Etudes et Techniques, Ministère de la Défense
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B (1975) An endotoxin-induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA 72:3666–3670
Chedid L, Parant M, Damais C, Parant F, Juy D, Galelli A (1976) Failure of endotoxin to increase nonspecific resistance to infection of lipopolysaccharide low-responder mice. Infect Immun 13:722–727
Chedid L, Skarnes RC, Parant M (1963) Characterization of 51Cr-labeled endotoxin and its identification in plasma and urine after parenteral administration. J Exp Med 117:561–571
Hoffmann M, Oettgen H, Old L, Mittler R, Hammerling U (1978) Induction and immunological properties of tumor necrosis factor. J Reticuloendothel Soc 23:307–319
Koenig S, Hoffmann MK, Thomas L (1977) Induction of the phenotypic lymphocyte differentiation in LPS unresponsive mice by an LPS-induced serum factor and by lipid A associated protein. J Immunol 118:1910–1911
Männel DN, Rosenstreich DL, Mergenhagen SE (1979) Mechanism of lipopolysaccharide-induced tumor necrosis: Requirement for lipopolysaccharide-sensitive lymphoreticular cells. Infect Immun 24:573–576
Matthews N (1978) Tumor necrosis factor from the rabbit. II. Production by monocytes. Br J Cancer 38:310–315
Moeller GR, Terry L, Snyderman R (1978) The inflammatory response and resistance to endotoxin in mice. J Immunol 120:116–123
Parant M, Parant F, Chedid L (1977) Inheritance of lipopolysaccharide-enhanced nonspecific resistance to infection and of susceptibility to endotoxic shock in lipopolysaccharide low-responder mice. Infect Immun 16:432–438
Parant M, Parant F, Chedid L (1978). Enhancement of the neonate’s nonspecific immunity to Klebsiella infection by muramyl dipeptide, a synthetic immunoadjuvant. Proc Natl Acad Sci USA 75:3395–3399
Ruco LP, Meltzer MS (1978) Defective tumoricidal capacity of macrophages from C3H/HeJ mice. J Immunol 120:329–334
Vas SI, Roy RS, Robson HG (1973) Endotoxin sensitivity of inbred mouse strains. Can J Microbiol 19:767–769
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1980 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Parant, M. (1980). Antimicrobial Resistance Enhancing Activity of Tumor Necrosis Serum Factor Induced by Endotoxin in BCG-Treated Mice. In: Mathé, G., Muggia, F.M. (eds) Cancer Chemo- and Immunopharmacology. Recent Results in Cancer Research, vol 75. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81491-4_33
Download citation
DOI: https://doi.org/10.1007/978-3-642-81491-4_33
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-81493-8
Online ISBN: 978-3-642-81491-4
eBook Packages: Springer Book Archive