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Inhibitors of RNA Synthesis Interacting with RNA Polymerases

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Inhibitors of Nucleic Acid Synthesis

Part of the book series: Molecular Biology, Biochemistry and Biophysics ((MOLECULAR,volume 18))

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Abstract

In this chapter the antibiotics are subdivided into those interacting with RNA polymerase from prokaryotic cells, and those interacting with RNA polymerases from eukaryotic organisms. The short introductory survey on prokaryotic and eukaryotic RNA polymerases is based on the reviews of BURGESS (1971), BLATTI et al. (1970) and KEDINGER et al. (1971). The protomeric form of RNA polymerase, which was first isolated from E. coli, contains the following polypeptide chain subunits: one β’ subunit; one β subunit; two α subunits; and one σ subunit. This RNA polymerase is designated as complete or holoenzyme (α2ββ’σ), which can be separated into two functional parts; a core enzyme (α2ββ’) which is able to synthesize RNA but lacks the ability to initiate RNA synthesis at specific points along the DNA chain and the sigma factor which acts catalytically and allows the initiation of RNA chains at specific sites.

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References

  • BLATTI, S.P., INGLES, C.J., LINDELL, T.J., MORRIS, P.W., WEAVER, R.F., WEINBERG, F., RUTTER, W.J.: Structure and regulatory properties of eucarvotic RNA polymerase. Cold Spr. Harb. Symp. quant. Biol. 35, 649–657 (1970).

    CAS  Google Scholar 

  • BURGESS, R.R.: RNA, polymerase. Ann. Rev. Biochem. 40, 711–740 (1971).

    PubMed  CAS  Google Scholar 

  • KEDINGER, D., NURET, P., CHAMBON, P.: Structural evidence for two a-amanitin sensitive RNA polymerases in calf thymus. FEBS Letters 15, 169–174 (1971).

    PubMed  CAS  Google Scholar 

  • POGO, A.O., LITTAU, V.C., SLLFRFY, V.G., IPSKY, A.E.: Modification of the ribonucleic acid synthesis in.nuclei isolated from normal and regenerating liver: Some effects of salt and specific divalent cations. Proc. nat. Acad. Sci. (Wash.) 57, 743–750 (1967).

    CAS  Google Scholar 

  • ROBERTS, J.W.: Termination factor of RNA synthesis. Nature 224, 1168–1174 (1969).

    PubMed  CAS  Google Scholar 

  • ROEDER, R.G., RUTTER, W.J.: Specific Nucleolar and Nucleoplasmic RNA Polymerases. Proc. nat. Acad. Sci. (Wash.) 155, 675–682 (1970).

    Google Scholar 

  • TRAVERS, A.A., KAMEN, R.I., SCHLEIF, R.F.: Factor necessary for ribosoirral RNA synthesis. Nature 228, 748–751 (1970).

    PubMed  CAS  Google Scholar 

  • WIDNELL, C.C., TATA, J.R.: Studies on the stimulation by ammonium sulphate of the DNA-dependent RNA polymerase of isolated rat liver nuclei. Biochim. biophys. Acta (Amst.) 123, 478–492 (1966).

    CAS  Google Scholar 

  • ZUBAY, G., SCHWARTZ, D., BECKWITH, J.: Mechanism of activation of catabolite-sensitive genes: A positive control system. Proc. nat. Acad. Sci. (Wash.) 66, 104–110 (1970).

    CAS  Google Scholar 

A. Rifamycin

  • BAUTZ, E., BAUTZ, F.: Initiation of RNA synthesis: The function of sigma in the binding of RNA-polymerase to promoter sites. Nature 226, 1219–1222 (1970a).

    PubMed  CAS  Google Scholar 

  • BAUTZ, E., BAUTZ, F.: Studies on the function of the RNA polymerase sigma factor in promoter selection. Cold. Spr. Harb. Symp. quant. Biol. 35, 227–232 (1970b).

    CAS  Google Scholar 

  • BINDA, G., DOMENICHINI, E., GOTTARDI, A., ORLANDI, B., ORTELLI, E., PACINI, B., FOWST, G.: Rifampicin, a general review. Arzneimittel-Forsch. 21, 1907–1977 (1971).

    CAS  Google Scholar 

  • BLATTI, S.P., INGLES, C.J., LINDELL, T.J., MORRIS, P.W., WEAVER, R.F., WEINBERG, F., RUTTER, W.J.: Structure and regulatory properties of eucaryotic RNA polymerase. Cold Spr. Harb. Symp. quant. Biol. 35, 649–657 (1970).

    CAS  Google Scholar 

  • BRUFANI, M., FEDELI, W., GIACOMELLO, G., VACIAGO, A.: The X-ray analysis of the structure of rifamycin B. Experentia (Basel) 20, 339 to 342 (1964).

    CAS  Google Scholar 

  • BUSIELLO, E., di GIROLAMQ, A., di GIROLAMQ, M., FISCHER-FANTUZZI, L., VESCO, C.: Multiple effects of rifamyci4 derivatives on animal-cell metabolism of macromolecules. Europ. J. Biochem. 35, 251–258 (1973).

    PubMed  CAS  Google Scholar 

  • CLEWELL, D.B., EVENCHIK, B., CRANSTON, J.W.: Direct inhibition of Col Ei plasmid DNA replication in E. coli by rifampicin. Nature New Biology 137, 29–31 (1972).

    Google Scholar 

  • CLEWELL, D.B., EVENCHIKB, G.: Effects of rifampicin, streptolydigin and actinomycin D on the replication of Col E plasmid DNA in Escherichia coli. J. molec. Biol. 75, 503–513 (1973).

    PubMed  CAS  Google Scholar 

  • DiMAURO, E., SNYDER, L., MARINO, P., LAMBERTI, A., COPPO, A., TOCCHINIVALENTINI, G.P.: Rifampicin sensitivity of the components of DNA- dependent RNA polymerase. Nature 222, 533–537 (1969).

    CAS  Google Scholar 

  • DOOLITTLE, W.F., PACE, N.R.: Synthesis of 5S ribosomal RNA in E. coli after rifamycin treatment. Nature 228, 125–129 (1970).

    PubMed  CAS  Google Scholar 

  • ENGELBERG, H.: Inhibition of RNA bacteriophage replication by rifampicin. J. molec. Biol. 68, 541–546 (1972).

    PubMed  CAS  Google Scholar 

  • FRONTALI, L., TECCE, G.,: Rifamycins. In: D. GOTTLIEB, P.D. SHAW (Eds.): Antibiotics, Vol. 1, Mechanism of Action, pp. 415–426. Berlin-Heidelberg-New York: Springer 1967.

    Google Scholar 

  • GADALETA, M.N., GRECO, M., ACCONE, C.: The effect of rifampicin on mitochondrial RNA polymerase from rat liver. FEBS Letters 10, 54–56 (1970).

    PubMed  CAS  Google Scholar 

  • GALLO, R.C., YANG, S.S., SMITH, R.G., HERRERA, F., TING, R.C., FUJIOKA, S.: Some observations on DNA polymerases of human normal and leukaemic cells. In: RIBBONS, D.W., WOESSNER, J.F., SCHULTZ, J. (Eds.): Nucleic Acid-Protein Interactions and Nucleic Acid Synthesis in Viral Infection, pp. 353–379. Amsterdam: North-Holland Publ. 1971.

    Google Scholar 

  • GALLO, R.C., YANG, S.S., TING, R.C.: RNA-dependent DNA polymerase of human acute leukaemic cells. Nature 228, 927–929 (1970).

    PubMed  CAS  Google Scholar 

  • GERARD, G.F., GURGO, C., GRANDGENETT, D.P., GREEN, M.: Rifamycin derivatives: Specific inhibitors of nucleic acid polymerases. Biochem. biophys. Res. Commun. 53, 194–201 (1973).

    PubMed  CAS  Google Scholar 

  • GOLDBERG, I.H., FRIEDMAN, P.A.: Antibiotics and nucleic acids. Ann. Rev. Biochem. 40, 775–810 (1971).

    PubMed  CAS  Google Scholar 

  • GRANT, W.D., POULTER, R.T.M.: Rifampicin-sensitive RNA and protein synthesis by isolated mitochondria of Physarum polycephalum. J. molec. Biol.13, 439–454 (1973).

    Google Scholar 

  • GURGO, C., GREEN, M.: Rifamycin derivatives strongly inhibiting RNA- DNA polymerase (reverse transcriptase) of murine sarcoma viruses. J. nat. Cancer Inst. 47 61–79 (1972).

    Google Scholar 

  • GURGO, C., RAY, R.K., THIRY, L., GREEN, M.: Inhibitors of the RNA and DNA dependent polymerase activities of RNA tumour viruses. Nature New Biology 229, 111–114 (1971).

    PubMed  CAS  Google Scholar 

  • HARFORD, N., SUEOKA, N.: Chromosomal location of antibiotic resistance markers in B. subtilis. J. molec. Biol. 51, 267–286 (1970).

    PubMed  CAS  Google Scholar 

  • HARTMANN, G., HONIKEL, K.O., KNÜSEL, F., NÜESCH, J.: The specific inhibition of the DNA-directed RNA synthesis by rifamycin. Biochim. biophys. Acta (Amst.) 445 843–844 (1967).

    Google Scholar 

  • HELLER, E., ARGAMAN, M., LEVY, H., GOLDBLUM, N.: Selective inhibition of vaccinia virus by the antibiotic rifampicin. Nature 222, 273 to 274 (1969).

    PubMed  CAS  Google Scholar 

  • HINKLE, D.C., MANGEL, W.F., CHAMBERLIN, M.J.: Studies on the binding of E. coli RNA polymerase to DNA. IV. The effect of rifampicin on binding and on RNA chain initiation. J. molec. Biol. 70, 209–220 (1972).

    PubMed  CAS  Google Scholar 

  • JOHNSTON, J.H., RICHMOND, M.H.: The increased rate of loss of penicillinase plasmids from Staph, aureus in the presence of rifampicin. J. gen. Microbiol. 60, 137–139 (1970).

    PubMed  CAS  Google Scholar 

  • KATES, J.R., MAUSLAN, B.R.: Poxvirus DNA-dependent RNA polymerase. Proc. nat. Acad. Sci. (Wash.) 58, 134–141 (1967).

    CAS  Google Scholar 

  • KERRICH-SANTO, R.E., HARTMANN, G.: On the formation of the rifampicin- resistant complex of RNA polymerase and DNA. Hoppe-Seylers Z. physiol. Chem. 353, 1535–1535 (1972).

    PubMed  CAS  Google Scholar 

  • KONINGS, R.N.H.: Personal communication.

    Google Scholar 

  • KNÜSEL, F., BICKEL, H., KUMP, W.: A new group of rifamycin derivatives displaying activity against rifampicin resistant mutants of Staph, aureus. Experientia (Basel) 25, 1207–1208 (1969).

    Google Scholar 

  • KRCMERY, V., JANOUSKOVA, J.: Effect of rifampicinon stability and transfer of R-factors. Z. allg. Mikrobiol. 11, 97–101 (1971).

    PubMed  CAS  Google Scholar 

  • LILL, U., HARTMANN, G.R.: Prevention of the binding of rifampicin to RNA polymerase. Hoppe Seylers Z. physiol. Chem. 353, 1544 (1972).

    PubMed  CAS  Google Scholar 

  • LILL, U.I., HARTMANN, G.R.: On the binding of rifampicin to the DNA- directed RNA polymerase from E. coli. Europ. J. Biochem. 38. 336–345 (1973).

    PubMed  CAS  Google Scholar 

  • LILL, H., LILL, U., SIPPEL, A., HARTMANN, G.: The inhibition of the RNA polymerase reaction by rifampicin. In: Proceedings of the 1st International Lepetit Colloquium on RNA Polymerase and Transcription (SILVESTRI, L., Ed.), pp. 55–64. London-Amsterdam: North Holland Publ. 1970.

    Google Scholar 

  • MARGALITH, P., PAGANI, H.: Rifomycin. XIV. Production of rifomycin B. Appl. Microbiol. 19, 325–334 (1961).

    Google Scholar 

  • MEIER, D., HOFSCHNEIDER, P.H.: Effect of rifampicin on the growth of RNA bacteriophage M12. FEBS Letters 25, 179–183 (1972).

    PubMed  CAS  Google Scholar 

  • MOSS, B., ROSENBLUM, E.N., KATZ, E., GRIMLEY, P.M.: Rifampicin: a specific inhibitor of vaccinia virus assembley. Nature 224, 1280 to 1284 (1960).

    Google Scholar 

  • OPPOLZER, W., PRELOG, V., SENSI, P.: Konstitution des Rifamycins B und verwandter Rifamycine. Experientia (Basel) 20, 336–339 (1964).

    CAS  Google Scholar 

  • PRELOG, V.: Über die Konstitution der Rifamycine. Chemotherapia (Basel) 1, 133–136 (1963a).

    Google Scholar 

  • PRELOG, V.: Constitution of rifamycins. Pure Appl. Chem.7, 551–564 (1963b).

    CAS  Google Scholar 

  • RABUSSAY, D., ZILLIG, W.: A rifampicin resistant RNA polymerase from E. coli altered in the ß-subunit. FEBS Letters 5, 104–106 (1969).

    PubMed  CAS  Google Scholar 

  • REID, P., SPEYER, J.: Rifampicin inhibition of ribonucleic acid and protein synthesis in normal and ethylenediaminetetraacetic acid- treated E. coli. J. Bact. 104, 376–389 (1970).

    PubMed  CAS  Google Scholar 

  • RIVA, S., FIETTA, A., SILVESTRI, L.G.: Mechanism of action of a rifamycin derivative (AF/013) which is active on the nucleic acid polymerases insensitive to rifampicin. Biochem. biophys. Res. Commun. 49, 1263–1271 (1972a).

    PubMed  CAS  Google Scholar 

  • RIVA, S., FIETTA, A.M., SILVESTRI, L.G., ROMERO, E.: Effect of rifampicin on expression of some episomal genes in E. coli. Nature New Biology 235, 78–80 (1972b).

    PubMed  CAS  Google Scholar 

  • RIVA, S., SILVESTRI, L.G.: Rifamycin: A General View. Ann. Rev. Microbiol. 26, 199–224 (1972).

    CAS  Google Scholar 

  • ROMERO, E., RIVA, S., FIETTA, A.M., SILVESTRI, L.G.: Effect of R factors on rifampicin resistance in E. coli. Nature New Biology 234, 56–58 (1971).

    PubMed  CAS  Google Scholar 

  • RODRIGUEZ-LOPEZ, M., MUNOZ, M.L., VAZQUEZ, D.: The effect of rifamycin antibiotics on algae. FEBS Letters 9, 171–174 (1970).

    PubMed  CAS  Google Scholar 

  • SAROV, I., BECKER, Y.: RNA in the elementary bodies of trachoma agent. Nature 217, 849–852 (1968).

    PubMed  CAS  Google Scholar 

  • SENSI, P., GRECO, A.M., BALOTTA, R.: Rifomycins. I. Isolation and properties of rifomycin B and rifomycin complex. Antibiot. Ann. 1959–60, pp. 262–270.

    Google Scholar 

  • SENTENAC, A., FROMAGEOT, P.: Effects of some RNA polymerase inhibitors on binding and chain initiation. In: T.H. BÜCHNER, H. SIES (Eds.): Mosbach Colloquium, pp. 64–75. Berlin-Heidelberg-New York: Springer 1969.

    Google Scholar 

  • SHMERLING, Z.G.: The effect of rifamycin on RNA synthesis in the rat liver mitochondria. Biochem. biophys. Res. Commun. 37, 965–969 (1969).

    PubMed  CAS  Google Scholar 

  • SILVESTRI, L. (Ed.): RNA-polymerase and transcription. Proc. of the I. Int. Lepetit. Coll., pp. 1–339. Amsterdam-London: North Holland Publ. 1970.

    Google Scholar 

  • SIPPEL, A., HARTMANN, G.: Mode of action of rifamycin on the RNA polymerase reaction. Biochim. biophys. Acta (Amst.) 157, 218–219 (1968).

    CAS  Google Scholar 

  • SIPPEL, A., HARTMANN, G.: Rifampicin resistance of RNA polymerase in the binary complex with DNA. Europ. J. Biochem. 14, 152–157 (1970).

    Google Scholar 

  • SMITH, R.G., WHANG-PENG, J., GALLO, R.C., LEVINE, P., TING, R.C.: Selective toxicity of rifamycin derivatives for leukaemic human leucocytes. Nature New Biology 236, 166–171 (1972).

    CAS  Google Scholar 

  • STAUDENBAUER, W.L., HOFSCHNEIDER, P.H.: Replication of bacteriophage M 13: Inhibition of single-strand DNA synthesis by rifampicin. Proc. nat. Acad. Sci. (Wash.) 69, 1634–1637 (1972).

    CAS  Google Scholar 

  • STRAAT, P.A., TSO, P.O.: Ribonucleic acid polymerase from Micrococcus luteus (Micrococcus lysodeikticus). IV. Effect of rifampicin and oligomers on the homopolymer-directed reaction. Biochemistry, 926–931 (1970).

    Google Scholar 

  • SUBAK-SHARPE, J.H., TIMBURY, M.C., WILLIAMS, J.F.: Rifampicin inhibits the growth of some mammalian viruses. Nature 222, 341–345 (1969).

    PubMed  CAS  Google Scholar 

  • SURZYCKI, S.J.: Genetic functions of the chloroplast of Chlamydomonas reinhardi: Effect of rifampicin on chloroplast DNA-dependent RNA polymerase. Proc. nat. Acad. Sci. (Wash.) 63, 1327–1334 (1969).

    CAS  Google Scholar 

  • TING, R.C., YANG, S.S., GALLO, R.C.: Reverse transcriptase, RNA tumour virus transformation and derivatives of rifamycin SV. Nature New Biology 236, 163–166 (1972).

    PubMed  CAS  Google Scholar 

  • TRAVERS, A.A., BURGESS, R.R.: Cyclic re-use of the RNA polymerase sigma factor. Nature 222, 537–540 (1969).

    PubMed  CAS  Google Scholar 

  • UMEZAWA, H., MIZUNO, S., YAMAZAKI, H., NITTA, K.: Inhibition of DNA- dependent RNA synthesis by rifamycins. J. Antibiot. (Tokyo) 21, 234–236 (1968).

    CAS  Google Scholar 

  • WEHRLI, W., KNÜSEL, F., SCHMID, K., STAEHELIN, M.: Interaction of rifamycin with bacterial RNA polymerase. Proc. nat. Acad. Sci. (Wash.) 61, 667–673 (1968b).

    CAS  Google Scholar 

  • WEHRLI, W., NÜESCH, J., KNÜSEL, F., STAEHELIN, M.: Action of rifamycins on RNA polymerase. Biochim. biophys. Acta (Amst.) 157, 215–217 (1968a).

    CAS  Google Scholar 

  • WEHRLI, W., STAEHELIN, M.: The rifamycins — relation of chemical structure and action on RNA polymerase. Biochim. biophys. Acta (Amst.) 182, 24–29 (1969).

    CAS  Google Scholar 

  • WEHRLI, W., STAEHELIN, M.: Interaction of rifamycin with RNA polymerase. In: Proc. I. Int. Lepetit Colloq. on RNA polymerase and transcription, pp. 65–70. Amsterdam-London: North-Holland Publ. 1970.

    Google Scholar 

  • WEHRLI, W., STAEHELIN, M.: Actions of rifamycins. Bacteriol. Rev. 35, 290–309 (1971).

    PubMed  CAS  Google Scholar 

  • WILHELM, J.M., OLEINICK, N.L., CORCORAN, J.W.: The inhibition of bacterial RNA synthesis by the rifamycin antibiotics. Biochim. biophys. Acta (Amst.) 166, 268–271 (1968).

    CAS  Google Scholar 

  • WINSTEN, J.A., HUANG, P.C.: Ribosomal RNA synthesis in vitro: A protein-DNA complex from Bacillus subtilis active in initiation of transcription. Proc. nat. Acad. Sci. (Wash.) 69, 1387–1391 (1972).

    CAS  Google Scholar 

  • WINTERSBERGER, E.: DNA-dependent RNA polymerase from mitochondria of a cytoplasmic “petite” mutant of yeast. Biochem. biophys. Res. Commun. 40, 1179–1184 (1970).

    PubMed  CAS  Google Scholar 

  • WU, C.W., GOLDTHWAIT, D.A.: Studies of nucleoside binding to the RNA polymerase by a fluorescence technique. Biochemistry 8, 4450–4458 (1969a).

    PubMed  CAS  Google Scholar 

  • WU, C.W., GOLDTHWAIT, D.A.: Studies on nucleotide binding to the RNA polymerase by equilibrium dialysis. Biochemistry 8, 4458–4464 (1969b).

    PubMed  CAS  Google Scholar 

  • YANG, S.S., HERRERA, F.M., SMITH, R.G., REITZ, M.S., LANCINI, G., TING, R.C., GALLO, R.C.: Rifamycin antibiotics: Inhibitors of Rauscher murine leukemia virus reverse transcriptase and of purified DNA polymerase from human normal and leukemic lymphoblasts. J. nat. Cancer Inst. 49, 7–25 (1972).

    PubMed  CAS  Google Scholar 

  • ZILLIG, W., FUCHS, E., PALM, P., RABUSSAY, D., ZECHEL, K.: On the different subunits of DNA-dependent RNA polymerase from E. coli and their role in the complex function of the enzyme. In: Proc. I. Int. Lepetit Colloq. on RNA Polymerase and Transcription, pp. 151–157. Amsterdam-London: North-Holland Publ. 1970a.

    Google Scholar 

  • ZILLIG, W., ZECHEL, K., RABUSSAY, D., SCHACHNER, M., SETHI, V.S., PALM, P., HEIL, A., SciFERT, W.: On the role of different subunits of DNA-dependent RNA polymerase from E. coli in the transcription process. Cold Spr. Harb. Symp. quant. Biol. 35, 47–58 (1970b).

    CAS  Google Scholar 

B. Streptovaricin

  • BORDEN, E.C., BROCKMAN, W.W., CARTER, W.A.: Selective inhibition by streptovaricin of splenomegaly induced by Rauscher leukaemia virus. Nature New Biology.232, 214–216 (1971).

    PubMed  CAS  Google Scholar 

  • BROCKMAN, W.W., CARTER, W.A., LI, L-H., REUSSER, F., NICHOL, F.R.: Streptovaricins inhibit RNA-dependent DNA polymerase present in an oncogenic RNA virus. Nature 230, 249–250 (1971).

    PubMed  CAS  Google Scholar 

  • CARTER, W.A., BROCKMAN, W.W., BORDEN, E.C.: Streptovaricins inhibit focus formation by MSV (MLV) complex. Nature New Biology 232, 212–214 (1971).

    PubMed  CAS  Google Scholar 

  • De BOER, C., MEULMAN, P.A., WNUK, R.J., PETERSON, D.H.: Geldanamycin, a new antibiotic. J. Antibiot. (Tokyo) 23, 442–447 (1970).

    Google Scholar 

  • KAMIYA, K., SUGINO, T., WADA, Y., NISHIKAWA, M., KISHI, T.: The X-ray analysis of tolypomycinone tri-m-bromobenzoate. Experientia (Basel) 25, 901–903 (1969).

    CAS  Google Scholar 

  • KISHI, T., ASAI, M., MUROI, M., HARADA, S., MIZUTA, E., TERAO, S., MIKI, T., MIZUNO, K.: Tolypomycin. I. Structure of tolypomycinone. Tetrahedron Letters 91–95 (1969a).

    Google Scholar 

  • KISHI, T., HARADA, S., ASAI, M., MUROI, M., MIZUNO, K.: Tolypomycin. II. Structures of tolyposamide and tolypomycin Y. Tetrahedron Letters 97–100 (1969b).

    Google Scholar 

  • MIZUNO, S., NITTA, K.: Effect of streptovaricin on RNA synthesis in phage T4-infected E. coli. Biochem. biophys. Res. Commun. 65, 127 to 130 (1969).

    Google Scholar 

  • MIZUNO, S., YAMAZAKI, H., NITTA, K., UMEZAWA, H.: Inhibition of DNA- dependent RNA polymerase reaction of E. coli by an antimicrobial antibiotic, streptovaricin. Biochim. biophys. Acta (Amst.) 157, 322–332 (1968).

    CAS  Google Scholar 

  • NITTA, S., MIZUNO, S., YAMAZAKI, H., UMEZAWA, H.: Streptovaricin- and rifampicin-resistance of RNA polymerase in a resistant clone of E. coli B. J. Antibiot. (Tokyo) 14, 521–522 (1968).

    Google Scholar 

  • PIATIGORSKY, J., WHITELEY, A.H.: A change in permeability and uptake of C1hCluridine in response to fertilization in Strongylocentrotus purpuratus eggs. Biochim. biophys. Acta (Amst.) 108, 404–418 (1965).

    CAS  Google Scholar 

  • RINEHART, K.L. Jr., MAHESHWARI, M.L., ANTOSZ, F.J., MATHUR, H.H., SASAKI, K., SCHACHT, R.J.: Chemistry of the streptovaricins. VIII. Structures of streptovaricins, A, B, D, E, F andGla. J.Amer. chem. Soc. 93 6273–6274 (1971).

    CAS  Google Scholar 

  • RHULAND, L.E., STERN, K.F., REAMES, H.R.: Streptovaricin. III. In vivo Studies in the tuberculous mouse. Amer. Rev. Tuberc. 75, 588–593 (1957).

    CAS  Google Scholar 

  • SASAKI, K., KENNETH, L., RINEHART, K.L., Jr., FREDERICK, J., ANTOSZ, F.J.: Chemistry of the streptovaricins. VI. Oxidation products from streptovaricin C. J. Antibiot. (Tokyo) 25, 68–70 (1972).

    CAS  Google Scholar 

  • SIMINOFF, P., SMITH, R.M., SOKOLSKI, W.T., SAVAGE, G.M.: Streptovaricin. I. Discovery and biologic activity. Amer. Rev. Tuberc. 75, 576–583 (1957).

    CAS  Google Scholar 

  • SOKOLSKI, W.T., EILERS, N.J., SIMINOFF, P.: Paper chromatography and assay of components in streptovarcin. Antibiot. Ann. (New York) 1957–1958, pp. 119–125.

    Google Scholar 

  • TAN, K.B., McAUSLAN, B.R.: Inhibition of nucleoside incorporation into HeLa cells by streptovaricin. Biochem. biophys. Res. Commun. 42, 230–236 (1971).

    PubMed  CAS  Google Scholar 

  • WANG, A.H.-J., PAUL, I.C., RINEHART, K.L., Jr., ANTOSZ, F.J.: Chemistry of the streptovaricins. IX. X-ray crystallographic structure of a streptovaricin C derivative. J. Amer. ehem. Soc. 93 6275 to 6276 (1971).

    CAS  Google Scholar 

  • WEHRLI, W., STAEHELIN, M.: The various actions of the rifamycins. Ciba-Geigy, Basel/Switzerland 1972.

    Google Scholar 

  • WHITEFIELD, G.B., OLSON, E.C., HERR, R.R., FOX, J.A., BERGY, M.E., BOYACK, G.A.: Streptovaricin. II. Isolation and properties. Amer. Rev. Tuberc. 15, 584–587 (1957).

    Google Scholar 

  • YURA, T., IGARASHI, K.: RNA polymerase mutants of E. coli. I. Mutants resistant to streptovaricins. Proc. nat. Acad. Sci. (Wash.) 61, 1313–1319 (1968).

    CAS  Google Scholar 

  • YURA, T., IGARASHI, H., MASUKATA, K.: Temperature-sensitive RNA polymerase mutants of E. coli. In: Proc. I. Int. Lepetit Colloq. on RNA polymerase and transcription, pp. 71–89. Amsterdam-London: North- Holland Publ. 1970.

    Google Scholar 

C. Streptolydigin

  • CASSANI, G., BURGESS, R.R., GOODMAN, H.M.: Streptolydigin inhibition of RNA polymerase. Cold Spr. Harb. Symp. quant. Biol. 35, 59–63.

    Google Scholar 

  • CASSANI, G., BURGESS, R.R., GOODMAN, H.M., GOLD, L.: Inhibition of RNA polymerase by streptolydigin. Nature New Biology 230, 197–200.

    Google Scholar 

  • De BOER, C., DIETZ, A., SILVER, S., SAVAGE, G.M.: Streptolydigin, a new antimicrobial antibiotic. I. Biological studies of streptolydigin. Antibiotics Ann. 1955–1956, 886–892.

    Google Scholar 

  • EBLE, T.E., LARGE, C.M., DeVRIES, W.H., CRUM, G.F., SCHELL, J.W.: Streptolydigin, an antimicrobial antibiotic. II. Isolation and characterization. Antibiotics Ann. 1955–1956, 893–896.

    Google Scholar 

  • RINEHART, K.L., Jr., BECK, J.R., BORDERS, D.B., KINSTLE, T.H., KRAUSS D.: Streptolydigin. III. Chromophore and structure. J. Amer. chem. Soc. 85, 4038–4039 (1963).

    CAS  Google Scholar 

  • SCHLEIF, R.: Isolation and characterization of a streptolydigin resistant RNA polymerase. Nature 223, 1068–1069 (1969).

    PubMed  CAS  Google Scholar 

  • SIDDHIKOL, C., ERBSTOESZER, J.W., WEISBLUM, B.: Mode of action of streptolydigin. J. Bact. 99, 151–155 (1969).

    PubMed  CAS  Google Scholar 

  • VHELM, K., KRAKOW, J.S.: Inhibition of RNA polymerase by streptolydigin. Nature New Biology 235, 82–83 and 240–296 (1972).

    Google Scholar 

  • ZILLIG, W., ZECHEL, K., RABUSSAY, D., SCHACHNER, M., SETHI, V.S., PALM, P., HEIL, A., SciFERT, W.: On the rule of different subunits of DNA-dependent RNA polymerase from E. coli in the transcription process. Cold Spr. Harb. Symp. quant. Biol. 35, 47–58 (1970).

    CAS  Google Scholar 

D. Amanitins

  • BEIDERBECK, R.: a-Amanitin hemmt die Tumorinduktion durch Agrobacte- rium tumefaciens. Z. Naturforsch. 27b, 1393–1394 (1972).

    Google Scholar 

  • BLATTI, S.P., INGLES, C.J., LINDELL, T.J., MORRIS, P.W., WEAVER, R.F., WEINBERG, F., RÜTTER, W.J.: Structure and regulatory properties of eucaryotic RNA polymerase. Cold Spr. Harb. Symp. 35, 649–657 (1970).

    CAS  Google Scholar 

  • DEZELEE, S., SENTENAC, A., FROMAGEOT, P.: Study on yeast RNA polymerase. Effect of a-amanitin and rifampicin. FEBS Letters 13, 220–222 (1970).

    Google Scholar 

  • FAULSTICH, H., WIELAND, T., JOCHUM, C.: Über die Inhaltstoffe des grünen Knollenblätterpilzes. Amanin und die Amanitine sind Sulfoxide Liebigs Ann. Chem. 713, 186–195 (1968).

    CAS  Google Scholar 

  • FIUME, L., La PLACA, M., PORTOLANI, M.: A study on the mechanism of the cytopathic action of a-amanitin. Sperimentale 116, 15–26 (1966)

    PubMed  CAS  Google Scholar 

  • FIUME, L., WIELAND, T.: Amanitins. Chemistry and action. FEBS Letters 8, 1–5 (1970).

    PubMed  CAS  Google Scholar 

  • JACOB, S.T., SAJDEL, E.M., MUNRO, H.N.: Specific action of a-amanitin on mammalian RNA polymerase protein. Nature 225, 60–62 (1970a).

    PubMed  CAS  Google Scholar 

  • JACOB, S.T., SAJDEL, E.M., MUNRO, H.N.: Different responses of soluble whole nuclear RNA polymerase and soluble nucleolar RNA polymerase to divalent cations and to inhibition by a-amanitin. Biochem. biophys. Res. Commun. 38, 765–770 (1970b).

    PubMed  CAS  Google Scholar 

  • JACOB, S.T., MUECKE, W., SAJDEL, E.M., MUNRO, H.N.: Evidence for extranucleolar control of RNA synthesis in the nucleolus. Biochem. biophys. Res. Commun. 40, 334–342 (1970c).

    PubMed  CAS  Google Scholar 

  • KEDINGER, C., GNIAZDOWSKI, M., MANDEL, J.L., Jr., GISSINGER, F., CHAMBON, P.: a-Amanitin: a specific inhibitor of one’of two DNA- dependent RNA polymerase activities from calf thymus. Biochem. biophys. Res. Commun. 38, 165–171 (1970).

    PubMed  CAS  Google Scholar 

  • KEDINGER, C., NURET, P., CHAMBON, P.: Structural evidence for two a-amanitin sensitive RNA polymerases in calf thymus. FEBS Letters 15, 169–174 (1971).

    PubMed  CAS  Google Scholar 

  • LINDELL, T.J., WEINBERG, F., MORRIS, P.W., ROEDER, R.G., RUTTER, W.J.: Specific inhibition of nuclear RNA polymerase II by a-amanitin. Science 170, 447–449 (1970).

    PubMed  CAS  Google Scholar 

  • MEIHLAC, M., KEDINGER, C., CHAMBON, P., FAULSTICH, H., GOVINDAN, M.V., WIELAND, T.: Amanitin binding to calf thymus RNA polymerase B. FEBS Letters 9, 258–260 (1970).

    PubMed  CAS  Google Scholar 

  • MONTANARO, N., NOVELLO, F., STIRPE, F.: Effect of a-amanitin on ribonucleic acid polymerase II of rat brain nuclei and on retention of avoidance conditioning. Biochem. J. 125, 1087–1090 (1971).

    PubMed  CAS  Google Scholar 

  • MONTECUCCOLI, G., NOVELLO, F., STIRPE, F.: Effect of a-amanitin poisoning on the synthesis of deoxyribonucleic acid and of protein in regenerating rat liver. Biochim. biophys. Acta 319, 199–208 (1973).

    PubMed  CAS  Google Scholar 

  • NIESSING, J., SCHNIEDERS, B., KUNZ, W., SciFART, K.H., SEKERIS, C.E.: Inhibition of RNA synthesis by a-amanitin in vivo. Z. Naturforsch. 25b, 1119–1125 (1970).

    Google Scholar 

  • NOVELLO, F., FIUME, L., STIRPE, F.: Inhibition by a-amanitin of ribonucleic acid polymerase solubilized from rat liver nuclei. Biochem. J. 46, 177–180 (1970).

    Google Scholar 

  • POGO, A.O., LITTAU, V.C., ALLFREY, V.G., MIRSKY, A.E.: Modification of the ribonucleic acid synthesis in nuclei isolated from normal and regenerating liver. Proc. nat. Acad. Sci. (Wash.) 57, 743–750 (1967).

    CAS  Google Scholar 

  • REEDER, R.H., ROEDER, R.G.: Ribosomal RNA synthesis in isolated nuclei J. molec. Biol. J57, 433–441 (1972).

    Google Scholar 

  • ROEDER, R.G., RUTTER, W.J.: Specific nucleolar and nucleoplasmic RNA polymerases. Proc. nat. Acad. Sci. (Wash.) 65, 675–682 (1970).

    CAS  Google Scholar 

  • SEIFART, K.H., SEKERIS, C.E.: a-amanitin, a specific inhibitor of transcription by mammalian RNA polymerase. Z. Naturforsch. 24b, 1538–1544 (1969).

    Google Scholar 

  • SHAAYA, E., CLEVER, U.: In vivo effects of a-amanitin on RNA synthesis in Calliphora erythrocephala. Biochim. biophys. Acta (Amst.) 272, 373–381 (1972).

    CAS  Google Scholar 

  • SHAAYA, E., SEKERIS, C.E.: Inhibitory effects of a-amanitin on RNA synthesis and induction of DOPA-decarboxyläse by ß-ecdysone. FEBS Letters 15, 333–336 (1971).

    Google Scholar 

  • STIRPE, F., FIUME, L.: Studies on the pathogenesis of liver necrosis by a-amanitin. Effect of a-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nuclei. Biochem. J. 105, 779–782 (1967).

    PubMed  CAS  Google Scholar 

  • TATA, J.R., HAMILTON, M.J., SHIELDS, D.: Effects of a-amanitin in vivo on RNA polymerase and nuclear RNA synthesis. Nature New Biology 238, 161–164 (1972).

    PubMed  CAS  Google Scholar 

  • WIELAND, T.: Poisonous principles of mushrooms of the genus Amanita. Science 159, 946–952 (1968).

    PubMed  CAS  Google Scholar 

  • WIELAND, T., GEBERT, U.: Über die Inhaltstoffe des grünen Knollenblätterpilzes. XXX. Strukturen der Amanitine. Liebigs Ann. Chem. 700, 157–173 (1966).

    CAS  Google Scholar 

  • WIELAND, T., WIELAND, O.: Chemistry and toxicology of the toxins of Amanita phalloides. Pharmacol. Rev., 87–107 (1 959).

    Google Scholar 

  • WIDNELL, C.C., TATA, J.R.: Studies on the stimulation by ammonium sulphate of the DNA-dependent RNA polymerase of isolated rat-liver nuclei. Biochim. biophys. Acta (Amst.) 123, 478–492 (1966).

    CAS  Google Scholar 

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  1. Physiologisch-Chemisches Institut, Universität Erlangen-Nürnberg, Wasserturmstr. 5, D-8520, Erlangen, Fed. Rep. Germany

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Kersten, H., Kersten, W. (1974). Inhibitors of RNA Synthesis Interacting with RNA Polymerases. In: Inhibitors of Nucleic Acid Synthesis. Molecular Biology, Biochemistry and Biophysics, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80855-5_4

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