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Bacterial Infection: Close Encounters at the Host Pathogen Interface pp 81–97Cite as

Mechanisms of Pathogenesis of Staphylococcal and Streptococcal Superantigens

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 225))

Abstract

In order to infect a host successfully, to access nutrients, and to promote the progression of disease, many pathogenic bacteria, such as the staphylococci and streptococci, produce exoproteins which enhance microbial virulence. Among these proteins is the family of toxins known today as the superantigens (SAg). This family includes the pyrogenic toxin SAg (PTSAg), such as the staphylococcal enterotoxins (SE, serotypes A-E, G, H), group A streptococcal pyrogenic exotoxins (SPE, serotypes A-C and possibly F), streptococcal SAg (SSA), and staphylococcal toxic shock syndrome toxin (TSST)-1. The following is a review of the biochemistry, structure, and mechanisms of pathogenicity of the PTSAg and the shared and unique properties of each. The properties of other relevant superantigenic proteins such as the staphylococcal exfoliative toxins (ETA, ETB) will also be discussed.

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  1. Department of Microbiology, University of Minnesota Medical School, Box 196 UMHC, 420 Delaware Str. SE, Minneapolis, MN, 55455-0312, USA

    J. V. Rago & P. M. Schlievert

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  1. J. V. Rago
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  1. Division of Oncovirology, BCC 239, Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Peter K. Vogt Ph.D.

  2. Department of Molecular, Cellular, and Developmental Biology, University of California, 93106, Santa Barbara, CA, USA

    Michael J. Mahan Ph.D.

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Rago, J.V., Schlievert, P.M. (1998). Mechanisms of Pathogenesis of Staphylococcal and Streptococcal Superantigens. In: Vogt, P.K., Mahan, M.J. (eds) Bacterial Infection: Close Encounters at the Host Pathogen Interface. Current Topics in Microbiology and Immunology, vol 225. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80451-9_5

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