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The Mechanism of Adenovirus DNA Integration: Studies in a Cell-Free System

  • Chapter
The Molecular Repertoire of Adenoviruses II

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 199/2))

Abstract

The understanding of recombinative interactions between foreign (viral) DNA and mammalian DNA is of interest not only in tumor virology, gene therapy, and the generation of transgenic animals, but also for models about the possible evolutionary role of foreign DNA integration into established genomes. Foreign DNA can recombine with the host DNA in mammalian cells and thus become integrated into the cellular genome by what has been termed “nonhomologous recombination.” Nonhomologous recombination plays a central role in the biology of mammalian systems and is thought to be more common in mammalian cells than homologous recombination.

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  1. J. Tatzelt

    Present address: Department of Neurology, University of California San Francisco, CA, 94143-0518, USA

  2. P. Wilgenbus

    Present address: Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

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  1. Institut für Genetik, Cologne University, Weyertal 121, 50931, Cologne, Germany

    K. Fechteler, J. Tatzelt, S. Huppertz, P. Wilgenbus & W. Doerfler

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  1. Institut für Genetik der Universität zu Köln, Weyertal 121, 50931, Köln, Germany

    Walter Doerfler  & Petra Böhm  & 

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Fechteler, K., Tatzelt, J., Huppertz, S., Wilgenbus, P., Doerfler, W. (1995). The Mechanism of Adenovirus DNA Integration: Studies in a Cell-Free System. In: Doerfler, W., Böhm, P. (eds) The Molecular Repertoire of Adenoviruses II. Current Topics in Microbiology and Immunology, vol 199/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79499-5_5

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  • Print ISBN: 978-3-642-79501-5

  • Online ISBN: 978-3-642-79499-5

  • eBook Packages: Springer Book Archive

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