Alzheimer’s Disease: Lessons from Cell Biology

1. Front Matter

   Pages I-XIX

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2. Endocytotic Pathways in Neurons

   • E. Grote, F. Bonzelius, G. Herman, M. Ramaswami, J. van de Goor, S. Green et al.

   Pages 1-13

3. Mechanisms of Molecular Sorting in Polarized Cells: Relevance to Alzheimer’s Disease

   • I. Mellman, K. Matter, E. Yamamoto, N. Pollack, J. Roome, K. Felsenstein et al.

   Pages 14-26

4. Regulation of Receptor Trafficking by ras-Like GTPases

   • S. R. Pfeffer

   Pages 27-36

5. Alzheimer’s Disease and Hemorrhagic Stroke: Their Relationship to βA4 Amyloid Deposition

   • L. Hendriks, P. Cras, J.-J. Martin, C. Van Broeckhoven

   Pages 37-48

6. Combining In Vitro Cell Biology and In Vivo Mouse Modelling to Study the Mechanisms Underlying Alzheimer’s Disease

   • B. De Strooper, D. Moechars, K. Lorent, I. Dewachter, F. Van Leuven

   Pages 49-65

7. Implication of the Amyloid Precursor Protein in Neurite Outgrowth

   • B. Allinquant, P. Hantraye, C. Bouillot, K. L. Moya, A. Prochiantz

   Pages 66-69

8. Physiological Production and Polarized Secretion of the Amyloid β-Peptide in Epithelial Cells: A Route to the Mechanism of Alzheimer’s Disease

   • D. J. Selkoe

   Pages 70-77

9. Regulation and Structure of the MAP Kinases ERK1 and ERK2

   • M. H. Cobb, J. E. Hepler, E. Zhen, D. Ebert, M. Cheng, A. Dang et al.

   Pages 78-87

10. Calcineurin as a Pivotal Ca2+-Sensitive Switching Element in Biological Responses: Implications for the Regulation of Tau Phosphorylation in Alzheimer’s Disease

    • R. L. Kincaid

    Pages 88-102

11. Phosphorylation of Tau and Its Relationship with Alzheimer Paired Helical Filaments

    • E.-M. Mandelkow, J. Biernat, B. Lichtenberg-Kraag, G. Drewes, H. Wille, N. Gustke et al.

    Pages 103-120

12. Posttranslational Modifications of the Tau in PHF: Phosphorylation and Ubiquitination

    • M. Morishima-Kawashima, Y. Ihara

    Pages 121-131

13. Tau Variants in Aging and Neurodegenerative Disorders

    • V. Buée-Scherrer, L. Buée, P. R. Hof, P. Vermersch, B. Leveugle, A. Wattez et al.

    Pages 132-149

14. A Phosphorylated Tau Species Is Transiently Present in Developing Cortical Neurons and Is Not Associated with Stable Microtubules

    • J. P. Brion, A. M. Couck, J. L. Conreur, J. N. Octave

    Pages 150-171

15. Modifications of Phosphorylated Tau Immunoreactivity Linked to Excitotoxicity in Neuronal Cultures

    • J. Hugon, P. Sindou, M. Lesort, P. Couratier, F. Esclaire, C. Yardin

    Pages 172-179

16. Neurofilaments and Motor Neuron Disease

    • D. W. Cleveland, Z. Xu

    Pages 180-192

17. Lurcher, Cell Death and the Cell Cycle

    • N. Heintz, L. Feng, J. Gubbay, S. Cheng, J. Zuo, P. L. De Jager et al.

    Pages 193-201

18. Neuronal Death, Proinflammatory Cytokines and Amyloid Precursor Protein: Studies on Staggerer Mutant Mice

    • B. Brugg, Y. Lemaigre-Dubreuil, G. Huber, B. Kopmels, N. Delhaye-Bouchaud, E. E. Wollman et al.

    Pages 202-216

19. Amyloid β-Peptide Induces Necrotic Cell Death in PC12 Cells

    • J. B. Davis, C. Behl, F. G. Klier, D. Schubert

    Pages 217-229

20. Linking Amyloid Precursor Protein Processing and Tau-Related Pathology in Alzheimer’s Disease

    • K. S. Kosik, A. Ferreira, R. Knowles, N. Leclerc, S. M. Greenberg

    Pages 230-240

Like the unflinching gaze of Captain Ahab walking the deck of the Pequod, Alzheimer researchers have had their sights fixed firmly on the disease for many years. Now, as this volume amply demonstrates, accomplished researchers from other fields, who have thought deeply about cell biological problems are applying their insights to Alzheimer's disease. The contri­ butions here represent the text versions of the proceedings from the tenth "Colloque medecine et recherche" of the Fondation IPSEN devoted to research on Alzheimer's disease. The symposium, entitled "Alzheimer's Disease: Lessons from Cell Biology" was held in Paris on April 25, 1994. As is apparent from the varied backgrounds of the contributors, the scientific pursuit of Alzheimer's disease has begun to meld with more basic disciplines, particularly cell biology. While on the one hand, new areas of specialization are continuously emerging, the boundaries of older disciplines are increas­ ingly blurred. Perhaps for most of the years since the first descriptions of the disease in 1907, the science of Alzheimer's disease was descriptive, and lay in the province of pathologists. This time period, during which a great deal was learned about the topography of senile plaques and neurofibrillary tangles, culminated with an ultrastructural description of these hallmark structures. The modern era of Alzheimer's disease research opened with the iden­ tification of the component proteins in plaques and tangles.

• Alzheimer
• Hemorrhagic Stroke
• aging
• alzheimer's disease
• amyloid precursor protein
• biology
• cell
• cell biology
• cellular processes
• neurodegenerative disorders
• proteins

• Harvard Medical School, Brigham and Women’s Hospital, Boston, USA

  K. S. Kosik, D. J. Selkoe

• Fondation IPSEN, Paris, France

  Y. Christen

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