Abstract
The major obstacle to immunotherapy of cancer is the poor immunogenicity of tumors, especially in man. This is somewhat surprising since the large number of genetic alternations found in advanced cancers should give rise to peptide neo-epitopes capable of being recognized in the context of MHC-I molecules by cytotoxic lymphocytes (Lurquin et al., 1989). Indeed, tumor-associated (Groen et al., 1987) and tumor-specific antigens (van der Bruggen and van den Eynde, 1992) which should be targets for immunological attack have recently been identified. This leads to the suspicion that foreign antigens are indeed present on most, or at least many, tumor cells and that tumor cells are not rejected as foreign because the response of the immune system to the presented foreign antigen is inadequate (Fearon et al., 1990).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Cristiano RJ, Smith LC and Woo SLC (1993) Hepatic gene therapy: Adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocytes. Proc Natl Acad Sci USA 90:2122–2126.
Curiel DT, Agarwal S, Wagner E, Cotten M (1991) Adenovirus enhancement of transferrin-polylysine-mediated gene delivery. Proc Natl Acad Sci USA 88:8850–8854.
Curiel DT, Agarwal S, Romer MU, Wagner E, Cotten M, Birnstiel ML and Boucher RC (1992) Gene transfer to respiratory epithelial cells via the receptor-mediated endocytosis pathway. Am J Respir Cell Mol Biol 6:247–252.
FitzGerald D, Padmanaban JPR, Pastan I and Willingham MC (1993) Adenovirus-induced release of epidermal growth factor and Pseudomonas toxin into the cytosol of KB cells during receptor-mediated endocytosis. Cell 32:607–617.
Lipman BJ, Silverstein SC and Steinberg TH (1990) Organic anion transport in macrophage membrane vesicles. J Biol Chem 265:2142–2147. Pastan I and Seth P (1987). Concepts In Viral Pathogenesis 141:46.
Page DT and Garvey JS (1979) Isolation and characterization of hepatocytes and kupffer cells. J Immunol Methods 27:159–173.
Roy Chowdhury N, Wu CH, Wu GY, Yemeni PC, Bommineni, VR and Roy Chowdhury JR (1993) Fate of DNA targeted to the liver by asialoglycoprotein receptor-mediated endocytosis in vivo. J Biol Chem 268:11265–11271.
Seglen PO (1976) Preparation of isolated rat liver cells. Methods Cell Biol 13:29–83.
Svensson U. and Persson R (1984) Entry of adenovirus 2 into Hela cells. J Virol 51:687–694.
Wagner E, Zatloukal K, Cotten M, Kirlappos H, Mechtler K, Curiel DT and Birnstiel ML (1992) Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes. Proc Natl Acad Sci USA 89:6099–6103.
Wilson JM, Grossman M, Cabrera JA, Wu CH and Wu GY (1992) A novel mechanism for achieving transgene persistence in vivo following somatic gene transfer into hepatocytes. J Biol Chem 267:11483–11489.
Wu GY, Zhan P, Sze LL, Rosenberg AR and Wu CH (1994) Incorporation of adenovirus into a ligand-based DNA carrier system results in retention of original receptor specificity and enhances targeted gene expression J. Biol Chem 269:1–5.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Maass, G. et al. (1994). The Generation of Tumor Vaccines by Adenovirus-Enhanced Transferrinfection of Cytokine Genes into Tumor Cells. In: Skouteris, G.G. (eds) Liver Carcinogenesis. NATO ASI Series, vol 88. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79215-1_29
Download citation
DOI: https://doi.org/10.1007/978-3-642-79215-1_29
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-79217-5
Online ISBN: 978-3-642-79215-1
eBook Packages: Springer Book Archive