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Identification and Quantification of Fibre-Induced Lipid Peroxidation Products By GC-MSD

  • Conference paper
Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres

Part of the book series: NATO ASI Series ((ASIH,volume 85))

Abstract

It is now well documented in the literature that mineral dusts and fibres induce the peroxidation of lipids present in many biological samples. The samples tested include among others, erythrocytes (Chvapil et al., 1976), subcellular fractions of silicotic lungs (Gupta and Kaw, 1982), lung homogenates of silica-exposed rats (Zsoldos et al., 1983), microsomal fractions of rat lung (Gulumian et al., 1983) and liver (Fontecave et al., 1987), liposomes (Weitzman and Weitberg, 1985) macrophages (Goodglick et al., 1989), and fibroblast cell cultures (Iguchi et al., 1993).

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References

  • Benedetti A, Fulceri R, Ferrali M, Ciccoli L, Esterbauer H, Comporti M (1982) Detection of carbonyl functions in phospholipids of liver microsomes in CCI4— and BrCCI3—poisoned rats. Biochim Biophys Acta 712: 628–638

    PubMed  CAS  Google Scholar 

  • Benedetti A, Comporti M, Fulceri R, Esterbauer H (1984) Cytotoxic aldehydes originating from the peroxidation of liver microsomal lipids. Identification of 4,5-dihydroxydecenal. Biochim Biophys Acta 792: 172–181

    PubMed  CAS  Google Scholar 

  • Benedetti A, Comporti M (1987) Formation, reactions and toxicity of aldehydes produced in the course of lipid peroxidation in cellular membranes. Bioelectrochem Bioenerg 18: 187–202

    Article  CAS  Google Scholar 

  • Bucknall T, Edwards HE, Kemsley KG, Moore JS, Phillips GO (1978) The formation of malonaldehyde in irradiated carbohydrates. Carbohydr Res 62: 49–59

    Article  CAS  Google Scholar 

  • Chvapil M, Stankova L, Malshet V (1976) Lipid peroxidation as one of the mechanisms of silica fibrogenicity? I. Study with erythrocytes. Environ Res 11: 78–88

    Google Scholar 

  • Curzio M, Poli G, Esterbauer H, Biasi F, DiMauro C, Dianzani MU (1986) Detection of carbonyl products of lipid peroxidation in rat pleural exudate. IRCS Med Sci 14: 984–985

    CAS  Google Scholar 

  • Des Rosiers C, Rivest M-J, Boily M-J, Jette M, Carrobe-Cohen A, Kumar A (1993) Gas chromatographic-Mass spectrometric assay of tissue malondialdehyde, 4-hydroxynonenal, and other aldehydes after their reduction to stable alcohols. Anal Biochem 208: 161–170

    Article  PubMed  Google Scholar 

  • Esterbauer H, Cheesman KH, Dianzani MU, Poli G, Slater TF (1982) Separation andcharacterization of the aldehydic products of lipid peroxidation stimulated by ADP—Fe2+ in rat liver microsomes. Biochem J 208: 129–140

    PubMed  CAS  Google Scholar 

  • Esterbauer H, Lang J, Zadravec S, Slater TF (1984) Detection of maionaldehyde by high-performance liquid chromatography. Methods in Ezymology 105: 319–328

    Article  CAS  Google Scholar 

  • Esterbauer H, Zollner H (1989) Methods for determination of aldehydic lipid peroxidation products. Free Rad Biol Med 7: 197–203

    Article  PubMed  CAS  Google Scholar 

  • Esterbauer H, Schaur RJ, Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, maionaldehyde and related aldehydes. Free Rad Biol Med 11: 81–128

    Article  PubMed  CAS  Google Scholar 

  • Fazio VM, Barrera G, Martinotti S, Farace MG, Giglioni B, Frati L, Manzari V, Dianzani MU (1992) 4-hydroxynonenal, a product od cellular lipid peroxidatoin, which modulates C-myc, and globin gene expression in K562 erythroleukemic cells. Cancer Res 52:4886–4871

    Google Scholar 

  • Fontecave M, Mansuy D, Jaouen M, Pezerat H (1987) The stimulatory effects of asbestos on NADPH-dependent lipid peroxidation in rat liver microsomes. Biochem J 241: 561–565

    PubMed  CAS  Google Scholar 

  • Gardner HW (1989) Oxygen radical chemistry of polyunsaturated fatty acids. Free Rad Biol Med 7: 65–86

    Article  PubMed  CAS  Google Scholar 

  • Goodglick LA, Pietras LA, Kane AB (1989) Evaluation of the causal relationship between crocidolite asbestos—induced lipid peroxidation and toxicity to macrophages. Am Rev Respir Dis 139: 1265–1273

    PubMed  CAS  Google Scholar 

  • Gulumian M, Sardianos F, Kilroe-Smith TA, Ockerse G (1983) Lipid peroxidation in microsomes induced by crocidolite fibres. Chem-Biol Interact 44: 111–118

    Article  PubMed  CAS  Google Scholar 

  • Gupta GSD, Kaw JL (1982) Formation of lipid peroxides in the subcellular fractions of silicotic lungs in rats. Eur J Respir Dis 63: 183–187

    PubMed  CAS  Google Scholar 

  • Gutteridge JMC (1979) Identification of malondialdehyde as the TBA-reactant formed by bleomycin-iron-radical damage to DNA. FEBS Lett 105: 278–282

    Article  PubMed  CAS  Google Scholar 

  • Hemler ME, Cook HW, Lands WEM (1979) Prostaglandin synthesis can be triggered by lipid peroxides. Archs Biochem Biophys 193: 340–345

    Article  CAS  Google Scholar 

  • Horton AA, Fairhurst S (1987) Lipid peroxidation and mechanisms of toxicity. CRC Crit Rev Toxicol 18: 27–79

    Article  CAS  Google Scholar 

  • Iguchi H, Kojo S, Ikeda M (1993) Lipid peroxidation and disintegration of the cell membrane structure in cultures of rat lung fibroblasts treated with asbestos. J Appl Toxicol 13: 269–275

    Article  PubMed  CAS  Google Scholar 

  • Janero DR (1990) Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury. Free Rad Biol Med 9: 515–540

    Article  PubMed  CAS  Google Scholar 

  • Lang J, Celetto C, Esterbauer H (1985) Quantitative determination of the lipid peroxidation product 4-hydroxynonenal by high-performance liquid chromatography. Anal Biochem 150: 369–378

    Article  PubMed  CAS  Google Scholar 

  • Leurs R, Rademaker B, Kramer K, Timmerman H, Bast A (1986) The effects of 4-hydroxy-2,3-trans-noneiLdl, on /3-adrenoceptors of rat lung membranes. Chem-Biol Interact 59: 211–218

    Article  PubMed  CAS  Google Scholar 

  • Natarajan V, Scribner WM, Taher MM (1993) 4-hydroxynonenal, a metabolite of lipid peroxidation, activates phospholipase D in vascular endothelial cells. Free Rad Biol Med 15:365–375.

    Google Scholar 

  • Norsten-Hoog C, Cronholm T (1990) Analysis of aldehydic lipid peroxidation products in rat liver and hepatocytes by gas chromatography and mass spectrometry of the oxime-tert-butyldimethylsilyl derivatives. Anal Chem 189: 131–137

    CAS  Google Scholar 

  • Rossi MA, Garramone A, Dianzani MU (1988) Stimulation of phospholipase C activity by 4-hydroxynonenal; influence of GTP and calcium concentration. Int J Tiss React 10: 321–325

    CAS  Google Scholar 

  • Rossi MA, Garramone A, Dianzani MU (1989) Effect of 4-hydroxy-2,3-fcms-nonenai, a lipid peroxidation product, on hepatic phospholipase C. Med Sci Res 17: 257–258

    CAS  Google Scholar 

  • Rossi MA, Fidale F, Garramone A, Esterbauer H, Dianzani MU (1990) Effect of 4–hydroxyalkenals on hepatic phosphatidylinositoMt,5-bisphosphate-phospholipase C. Biochem Pharmacol 39: 1715–1719

    Article  PubMed  CAS  Google Scholar 

  • Rossi MA, Curzio M, Di Mauro C, Fidale F, Garramone A, Esterbauer H, Torrielli M, Dianzani MU (1991) Experimental studies on the mechanism of action of 4-hydroxy-2,3-Fnms-nonenal, a lipid peroxidation product displaying chemotactic activity toward rat neutrophils. Cell Biochem Funct 9: 163–170

    Article  PubMed  CAS  Google Scholar 

  • Sasaguri Y, Nakashima T, Morimatsu M, Yagi K (1984) Injury to cultured endothelial cells from human umbilical vein by linoleic acid hydroperoxide. J Appl Biochem 6: 144–150

    PubMed  CAS  Google Scholar 

  • Smith CV, Anderson RE (1987) Methods for determination of lipid peroxidation in biological samples. Free Rad Biol Med 3: 341–344

    Article  PubMed  CAS  Google Scholar 

  • Snyder GD, Capdevila J, Chacos N, Manna S, Faick JR (1983) Action of luteinizing Hormone-releasing hormone: involvement of novel arachidonic acid metabolites. Proc Natn Acad Sci USA 80: 3504–3507

    Article  CAS  Google Scholar 

  • Van Kuijk FJGM, Thomas DW, Stephens RJ, Dratz EA (1986) Occurence of 4-hydroxyalkenals in rat tissues determined as pentailuorobenzyl oxime derivatives by gas chromatography-mass spectroscopy. Biochem Biophys Res Commun 139: 144–149

    Article  PubMed  Google Scholar 

  • Weitzman SA, Weitberg AB (1985) Asbestos-catalysed lipid peroxidation and its inhibition by desferoxamine. Biochem J 225: 259–262

    PubMed  CAS  Google Scholar 

  • Yoshino K, Matsuura T, Sano M, Saito S.-I., Tomita I (1986) Fluorometric liquid chromatographic determination of aliphatic aldehydes arising from lipid peroxides. Chem Pharm Bull 34: 1694–1700

    PubMed  CAS  Google Scholar 

  • Zsoldos T, Tigyi A, Montsko T, Puppi A (1983) Lipid peroxidation in the membrane damaging effect of silica—containing dust on rat lungs. Exp Path 23: 73–77

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. National Centre for Occupational Health, P O Box 4788, Johannesburg, 2000, South Africa

    M. Gulumian & K. Ambaram

  2. Department of Medical Biochemistry, University of the Witwatersrand, P O Wits 2050, South Africa

    M. Gulumian

  3. Department of Chemistry and Biochemistry, Rand Afrikaans University, P O Box 524, Aukland Park, 2006, South Africa

    G. H. Verdoon

Authors
  1. M. Gulumian
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  2. K. Ambaram
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  3. G. H. Verdoon
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Editor information

Editors and Affiliations

  1. Institute of Occupational Medicine, 8 Roxburgh Place, Edinburgh, EH8 9SU, Scotland

    John M. G. Davis

  2. Unité 139 CHU Henri Mondor, INSERM, Creteil, Cedex, France

    Marie-Claude Jaurand

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© 1994 Springer-Verlag Berlin Heidelberg

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Gulumian, M., Ambaram, K., Verdoon, G.H. (1994). Identification and Quantification of Fibre-Induced Lipid Peroxidation Products By GC-MSD. In: Davis, J.M.G., Jaurand, MC. (eds) Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres. NATO ASI Series, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79041-6_43

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  • DOI: https://doi.org/10.1007/978-3-642-79041-6_43

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-79043-0

  • Online ISBN: 978-3-642-79041-6

  • eBook Packages: Springer Book Archive

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