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Animal Models of the Alcohol Addiction Process

  • Chapter
The Pharmacology of Alcohol Abuse

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 114))

Abstract

Historically, animal models of alcohol addiction have been reflective of the current definitions and understanding of alcohol addiction in humans. Thus, in conjunction with the increasing biomedical approach to alcoholism, the hallmarks of human alcohol dependence in the early 1960s and into the 1970s were tolerance and physical dependence. During this period, most animal models of alcoholism were designed to demonstrate both an increased ability to tolerate the effects of alcohol and the emergence of withdrawal signs following the cessation of alcohol treatment. The major use of animal models was to define the neuropharmacological adaptation to prolonged exposure to alcohol in the hopes that these adaptations would reveal the critical stages of the addiction process.

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Grant, K.A. (1995). Animal Models of the Alcohol Addiction Process. In: Kranzler, H.R. (eds) The Pharmacology of Alcohol Abuse. Handbook of Experimental Pharmacology, vol 114. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78435-4_9

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