Abstract
The rat subcommissural organ (SCO) is remarkable for the glandular activity of its ependymocytes, which release their secretory products in the cerebrospinal fluid. Great attention has been paid to the nervous input to the SCO and marked species differences have been reported (see review by Bouchaud, this volume). In all mammals, in contrast to many other regions of the ventricular lining, the apical surface of the SCO is devoid of a supraependymal serotoninergic plexus; however, in the rat, the basal part of the organ is innervated by a dense plexus of fine serotoninergic fibers arising from different raphe nuclei (Léger et al. 1983). The serotoninergic fibers run between the SCO ependymocytes and their axonal varicosities form true synaptic contacts, mainly with the laterobasal portion of the ependymocytes (Bouchaud and Arluison 1977).
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beaudet A, Sotelo C (1981) Synaptic remodeling of serotonin axon terminals in rat agranular cerebellum. Brain Res 206: 305–329
Bouchaud C, Arluison M (1977) Serotoninergic innervation of ependymal cells in the rat subcommissural organ. A fluorescence, electron microscopic and radioautographic study. Biol Cell 30: 61–64
Chan-Palay V (1975) Fine structure of labelled axons in the cerebellar cortex and nuclei of rodents and primates after intraventricular infusions with tritiated serotonin. Anat Embryol 148: 235–265
Didier-Bazes M, Aguera M, Chouaf L, Harandi M, Calas A, Meiniel A, Belin MF (1989) Neuronal control of [3H] GABA uptake in the ependymocytes of the subcommissural organ: an in-vivo model of neuron-glia interaction. Brain Res 489: 137–145
Hicks SP, d’Amato CJ (1963) Low dose radiation of developing brain. Science 141: 903–905
Leger L, Deguerce A, Lundberg JJ, Pujol JF, Møllgård K (1983) Origin and influence of serotonergic innervation of the subcommissural organ in the rat. Neuroscience 10: 411–423
Lidov HGW, Molliver ME (1982) An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields. Brain Res Bull 8: 389–430
Mareinkiewicz M, Bouchaud C (1986) Formation and maturation of axo-glandular synapses and concomitant changes in the target cells of the rat subcommissural organ. Biol Cell 56: 57–65
Møllgård K, Wiklund L (1979) Serotoninergic synapses on ependymal and hypendymal cells of the rat subcommissural organ. J Neurocytol 8: 445–467
Parent A, Descarries L, Beaudet A (1981) Organization of ascending serotonin systems in the adult rat brain. A radioautographic study after intraventricular administration of [3H]5-hydroxytryptamine. Neuroscience 6: 115–138
Soghomonian JJ, Beaudet A, Descarries L (1988) Ultrastructural relationship of central serotonin neurons. In: Osborne NN, Hamon M (eds) Neuronal serotonin. Wiley, Chichester, pp 57–92
Wallace JA, Lauder JM (1983) Development of the serotonergic system in the rat embryo: an immunocytochemical study. Brain Res Bull 10: 459–479
Wiklund L, Lundberg JJ, Møllgård K (1977) Species differences in serotoninergic innervation nd secretory activity of rat, gerbil, mouse and rabbt subcommissural organ. Acta Physiol Scand [Suppl 452]:27–30
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1993 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Delhaye-Bouchaud, N., Bouchaud, C. (1993). Impairment of the Serotoninergic Innervation of the Rat Subcommissural Organ After Early Postnatal X-Irradiation of the Brain Stem. In: Oksche, A., Rodríguez, E.M., Fernández-Llebrez, P. (eds) The Subcommissural Organ. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78013-4_20
Download citation
DOI: https://doi.org/10.1007/978-3-642-78013-4_20
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-78015-8
Online ISBN: 978-3-642-78013-4
eBook Packages: Springer Book Archive