Skip to main content

The Subcommissural Organ of the Rat: An In Vivo Model of Neuron—Glia Interactions

  • Conference paper
The Subcommissural Organ

Abstract

It is established that neurotransmitters in general and serotonin (5HT) in particular have a trophic role in the maturation of the central nervous system (CNS) (Lauder 1983). This action could be mediated in part via regulation of glia since neuron—glia interactions are necessary for the maturation of both neurons and glia (Hatten and Mason 1986; Holton and Weston 1982; Le Prince et al. 1990) and since glial cells in the CNS possess receptors for neurotransmitters (Whitaker-Azmitia 1988).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bouchaud C, Arluison M (1977) Serotoninergic innervation of ependymal cells in the rat subcommissural organ; a fluorescence electron microscopic and radioautographic study. Biol Cell 30: 65–72

    Google Scholar 

  • Chouaf L, Didier-Bazes M, Aguera M, Tardy M, Sallanon M, Kitahama K, Belin MF (1989) Comparative marker analysis of the ependymocytes of the subcommissural organ in four different mammalian species. Cell Tissue Res 257: 255–262

    Article  PubMed  CAS  Google Scholar 

  • Chouaf L, Didier-Bazes M, Hardin H, Aguera M, Fevre-Montange M, Voutsinos B, Belin MF (1991) Developmental expression of glial markers in subcommissural organ ependymocytes of the rat: role of the environment. Cell Tissue Res 266: 553–561

    Article  PubMed  CAS  Google Scholar 

  • Didier M, Harandi M, Aguera M, Bancel B, Tardy M, Fages C, Calas A, Stagaard M, Møllgård DK, Belin MF (1986) Differential immunocytochemical staining for glial fibrillary acidic (GFA) protein, S100 protein and glutamine synthetase in the rat subcommissural organ and non specialized ventricular ependyma and adjacent neuropil. Cell Tissue Res 245: 243–351

    Article  Google Scholar 

  • Didier-Bazes M, Aguera M, Chouaf L, Harandi M, Calas A, Meiniel A, Belin MF (1989) Neuronal control of [3H] GABA uptake in the ependymocytes of the subcommissural organ: an in vivo model of neuron-glia interaction. Brain Res 489: 137–145

    Article  PubMed  CAS  Google Scholar 

  • Didier-Bazes M, Chouaf L, Hardin H, Aguera M, Fèvre-Montange M, Belin MF (1991) Developmental neuron-glia interaction: role of the serotonin innervation upon the onset of GABA uptake into the ependymocytes of the rat subcommissural organ. Dev Brain Res 63: 135–139

    Article  CAS  Google Scholar 

  • Gamrani H, Belin MF, Aguera M, Calas A, Pujol JF (1981) Radioautographic evidence for an innervation of the subcommissural organ by GABA-containing nerve fibres. J Neurocytol 10: 411–424

    Article  PubMed  CAS  Google Scholar 

  • Hatten ME, Mason CA (1986) Neuron-astroglia interactions in vitro and in vivo. Trends Neurosci 9: 168–174

    Article  Google Scholar 

  • Holton B, Weston J (1982) Analysis of glial cell differentiation in peripheral nervous tissue. II. Neurons promote S-100 synthesis by purified glial precursor cell populations. Dev Biol 89: 72–81

    Article  PubMed  CAS  Google Scholar 

  • Lauder JM, Wallace JA, Krebs H, Petruz P, Mc Carthy K (1982) In vivo and in vitro development of serotonergic neurons. Brain Res Bull 9: 605–625

    Article  PubMed  CAS  Google Scholar 

  • Lauder JM (1983) Hormonal and humoral influences on brain development. Psychoneuroendocrinology 8: 121–155

    Article  PubMed  CAS  Google Scholar 

  • Léger L, Degueurce A, Lundberg JJ, Pujol JF, Møllgård K (1983) Origin and influence of the serotoninergic innervation of the subcommissural organ in the rat. Neuroscience 2: 411–423

    Article  Google Scholar 

  • Lepetit P, Touret M, Grange E, Gay N, Bobillier P (1991) Inhibition of methionine incorporation into brain proteins after the systemic administration of p-chlorophenylalanine and L-5-hydroxytryptophan. Eur J Pharmacol 209: 207–212

    Article  PubMed  CAS  Google Scholar 

  • Le Prince G, Copin MC, Hardin H, Belin MF, Bouilloux JP, Tardy M (1990) Neuron-glia interactions: effect of serotonin on the astroglial expression of GFAP and of its encoding message. Dev Brain Res 51: 295–298

    Article  Google Scholar 

  • Lestage P, Gonon M, Lepetit P, Vitte PA, Debilly G, Rossatto C, Lecestre D, Bobillier P (1987) An in vivo kinetic model with L-35S-methionine for the determination of local cerebral rates of methionine incorporation into protein in the rat. J Neurochem 48: 352–363

    Article  PubMed  CAS  Google Scholar 

  • Marcinkiewicz M, Bouchaud C (1986) Formation and maturation of axo-glandular synapses and concomitant changes in the target cells of the rat subcommissural organ. Biol Cell 56: 57–65

    PubMed  CAS  Google Scholar 

  • Redecker P (1989) Immunohistochemical localisation of glial fibrillary acidic protein (GFAP) and vimentin in the subcommissural organ of the Mongolian gerbil (Meriones unguiculatus). Cell Tissue Res 255: 595–600

    Article  PubMed  CAS  Google Scholar 

  • Reynolds R, Herschkowitz N (1987) Oligodendroglial and astroglial heterogeneity in mouse primary central nervous system culture as demonstrated by differences in GABA and D-aspartate transport and immunocytochemistry. Dev Brain Res 36: 13–25

    Article  CAS  Google Scholar 

  • Schousboe A, Drejer J, Meier E, Larsson OM, Schousboe I (1986) Regional heterogeneity of astrocytic transport processes for glutamate and GABA. Adv Biosci 61: 225–233

    CAS  Google Scholar 

  • Whitaker-Azmitia PM (1988) Astroglial serotonin receptors. In: Kimelberg HK (ed) Glial cell receptors. Raven, New York, pp 107–120

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Didier-Bazes, M., Chouaf, L., Lepetit, P., Aguera, M., Belin, M.F. (1993). The Subcommissural Organ of the Rat: An In Vivo Model of Neuron—Glia Interactions. In: Oksche, A., Rodríguez, E.M., Fernández-Llebrez, P. (eds) The Subcommissural Organ. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78013-4_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-78013-4_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78015-8

  • Online ISBN: 978-3-642-78013-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics