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Influence of Anesthetic Agents on the Regional Cerebral Blood Flow in Rabbits with a Focal Cerebral Lesion and General Hypoxia

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Intracranial Pressure VIII

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Abstract

Secondary brain damage is a major determinant of morbidity and mortality in patients with severe head injury. Shock or hypoxia after trauma are the most important extracerebral factors, which affect outcome [4]. Patients with severe head injury often require anesthesia for diagnostic or surgical procedures. Anesthetic agents may either exert cerebroprotective effects by a decrease of brain metabolism or elevate the intracranial pressure by an increase of cerebral blood flow. We have analyzed the effect of various anesthetic agents on rCBF after a focal cerebral lesion combined with systemic hypoxia.

Supported by Deutsche Forschungsgemeinschaft Ba 452/6–7

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References

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Author information

Authors and Affiliations

  1. Institute for Anesthesiology, Ludwig-Maximilians-Universitaire, 8000, München 70, Germany

    R. Murr, R. Enzenbach & K. Peter

  2. Institute for Surgical Research, Klinikum Großhadern, Ludwig-Maximilians-Universitaire, 8000, München 70, Germany

    L. Schürer, S. Berger & A. Baethmann

Authors
  1. R. Murr
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  2. L. Schürer
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  3. S. Berger
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  4. R. Enzenbach
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  5. K. Peter
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  6. A. Baethmann
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Editor information

Editors and Affiliations

  1. Dept. of Neurosurgery, University Hospital Rotterdam, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands

    C. J. J. Avezaat

  2. Central Dept. of Automation and Informatics, University Hospital Rotterdam, The Netherlands

    J. H. M. van Eijndhoven

  3. Dept. of Neurosurgery, University Hospital Rotterdam, The Netherlands

    A. I. R. Maas

  4. Dept. of Neurology, Westeinde Hospital, Lijnbaan 32, 2512 VA, Den Haag, The Netherlands

    J. Th. J. Tans

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© 1993 Springer-Verlag Berlin Heidelberg

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Murr, R., Schürer, L., Berger, S., Enzenbach, R., Peter, K., Baethmann, A. (1993). Influence of Anesthetic Agents on the Regional Cerebral Blood Flow in Rabbits with a Focal Cerebral Lesion and General Hypoxia. In: Avezaat, C.J.J., van Eijndhoven, J.H.M., Maas, A.I.R., Tans, J.T.J. (eds) Intracranial Pressure VIII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77789-9_143

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  • DOI: https://doi.org/10.1007/978-3-642-77789-9_143

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77791-2

  • Online ISBN: 978-3-642-77789-9

  • eBook Packages: Springer Book Archive

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